Some aspects of fatty acid metabolism in brown adipose tissue

Lipids ◽  
1970 ◽  
Vol 5 (2) ◽  
pp. 220-223 ◽  
Author(s):  
Eric G. Ball
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Brown Adipose

scholarly journals Fatty acid metabolism and the basis of brown adipose tissue function

Adipocyte ◽  
2016 ◽  
Vol 5 (2) ◽  
pp. 98-118 ◽  
Author(s):  
María Calderon-Dominguez ◽  
Joan F. Mir ◽  
Raquel Fucho ◽  
Minéia Weber ◽  
Dolors Serra ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Brown Adipose

scholarly journals Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Denis P. Blondin ◽  
Hans C. Tingelstad ◽  
Christophe Noll ◽  
Frédérique Frisch ◽  
Serge Phoenix ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Dietary Fatty Acid ◽  
Brown Adipose

scholarly journals A novel tracer for in vivo optical imaging of fatty acid metabolism in the heart and brown adipose tissue

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Marcello Panagia ◽  
Jing Yang ◽  
Eric Gale ◽  
Huan Wang ◽  
Ivan Luptak ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Optical Imaging ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Brown Adipose ◽  
In Vivo Optical Imaging

Uncoupling protein 3 and fatty acid metabolism

2001 ◽  
Vol 29 (6) ◽  
pp. 785-791 ◽  
Author(s):  
A. G. Dulloo ◽  
S. Samec ◽  
J. Seydoux
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Lipid Oxidation ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Gene Knockout ◽  
Uncoupling Protein ◽  
Brown Adipose ◽  
Genes Encoding

A role for uncoupling protein (UCP) 3 in fatty acid metabolism is reviewed within the context of our proposal, first put forward in 1998, that this homologue of UCP1 may be involved in the regulation of lipids as fuel substrate rather than in the mediation of thermogenesis. Since then, the demonstrations of muscle-type differences in UCP3 gene regulation in response to dietary manipulations (starvation, high-fat feeding) or to pharmacological interferences with the flux of lipid substrates between adipose-tissue stores and skeletal-muscle mitochondrial oxidation are all in accord with this proposed role for UCP3 in regulating lipids as fuel substrate. However, given the current limitations of gene-knockout technology for evaluating/interpreting the functional importance of genes encoding mitochondrial membrane proteins, the transition from ‘associative’ to ‘cause-and-effect’ evidence for a physiological role of UCP3 in regulating fatty acid metabolism will have to await the development of assays that are sensitive to changes in UCP3 activity. Furthermore, in evaluating the physiological regulators of UCP3, the available evidence points to the existence of adipose-derived factor(s) which, independently of circulating levels of free fatty acids, initiates events leading to the transcription of genes encoding UCP3 and key enzymes of lipid oxidation in the fast glycolytic or fast oxidative-glycolytic muscles, i.e. in the bulk of the skeletal-muscle mass. It is proposed that in tissues where UCP3 co-exists with UCP2 (skeletal muscle, brown adipose tissue, heart) they may act in concert in the overall regulation of lipid oxidation, concomitant to the prevention of lipid-induced oxidative damage.

scholarly journals Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown adipose tissue

iScience ◽  
2021 ◽  
pp. 102434
Author(s):  
Winifred W. Yau ◽  
Kiraely Adam Wong ◽  
Jin Zhou ◽  
Nivetha Kanakaram Thimmukonda ◽  
Yajun Wu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Fatty Acid Oxidation ◽  
Cold Exposure ◽  
Acid Oxidation ◽  
Brown Adipose ◽  
Mitochondrial Turnover

Role of the AMP-activated protein kinase in regulating fatty acid metabolism during exerciseThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

2009 ◽  
Vol 34 (3) ◽  
pp. 315-322 ◽  
Author(s):  
Gregory R. Steinberg
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Protein Kinase ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Moderate Intensity ◽  
Amp Activated Protein Kinase

During moderate-intensity exercise, fatty acids are the predominant substrate for working skeletal muscle. The release of fatty acids from adipose tissue stores, combined with the ability of skeletal muscle to actively fine tune the gradient between fatty acid and carbohydrate metabolism, depending on substrate availability and energetic demands, requires a coordinated system of metabolic control. Over the past decade, since the discovery that AMP-activated protein kinase (AMPK) was increased in accordance with exercise intensity, there has been significant interest in the proposed role of this ancient stress-sensing kinase as a critical integrative switch controlling metabolic responses during exercise. In this review, studies examining the role of AMPK as a regulator of fatty acid metabolism in both adipose tissue and skeletal muscle during exercise will be discussed. Exercise induces activation of AMPK in adipocytes and regulates triglyceride hydrolysis and esterfication through phosphorylation of hormone sensitive lipase (HSL) and glycerol-3-phosphate acyl-transferase, respectively. In skeletal muscle, exercise-induced activation of AMPK is associated with increases in fatty acid uptake, phosphorylation of HSL, and increased fatty acid oxidation, which is thought to occur via the acetyl-CoA carboxylase-malony-CoA-CPT-1 signalling axis. Despite the importance of AMPK in regulating fatty acid metabolism under resting conditions, recent evidence from transgenic models of AMPK deficiency suggest that alternative signalling pathways may also be important for the control of fatty acid metabolism during exercise.

Effect of metformin on glucose and fatty acid utilization in brown adipose tissue

2015 ◽  
Vol 241 (1) ◽  
pp. e46 ◽  
Author(s):  
J. Trnovska ◽  
V. Skop ◽  
H. Malinska ◽  
L. Kazdova
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Fatty Acid Utilization ◽  
Brown Adipose
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