Fatty acid and long chain base composition of adrenal medulla gangliosides

Lipids ◽  
1970 ◽  
Vol 5 (9) ◽  
pp. 751-756 ◽  
Author(s):  
Robert Ledeen ◽  
Kenneth Salsman
Keyword(s):  
Fatty Acid ◽  
Adrenal Medulla ◽  
Base Composition ◽  
Chain Base ◽  
Long Chain Base ◽  
Long Chain

Ceramid-1-phosphoethanolamine aus Myxococcus stipitatus/ Ceramide-1-phosphoethanolamines from Myxococcus stipitatus

1988 ◽  
Vol 43 (8) ◽  
pp. 1063-1068 ◽  
Author(s):  
J. Stein ◽  
H. Budzikiewicz
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Component ◽  
Acid Component ◽  
Chain Base ◽  
Long Chain Base ◽  
Ceramide 1 ◽  
Long Chain

AbstractThe structures of six ceramide-1-phosphoethanolamines have been elucidated which differ in the long chain base as well as in the fatty acid component

scholarly journals Long chain base composition of strains of three species ofSphingobacteriumgen. nov.

1982 ◽  
Vol 15 (4) ◽  
pp. 303-307 ◽  
Author(s):  
Ikuya Yano ◽  
Ikuko Tomiyasu ◽  
Eiko Yabuuchi
Keyword(s):  
Base Composition ◽  
Chain Base ◽  
Long Chain Base ◽  
Long Chain

Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria

FEBS Letters ◽  
2001 ◽  
Vol 488 (3) ◽  
pp. 160-164 ◽  
Author(s):  
D Ardail ◽  
I Popa ◽  
K Alcantara ◽  
A Pons ◽  
J.P Zanetta ◽  
...  
Keyword(s):  
Rat Liver ◽  
Base Composition ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Chain Base ◽  
Long Chain Base ◽  
Long Chain

scholarly journals Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver

1990 ◽  
Vol 270 (3) ◽  
pp. 815-820 ◽  
Author(s):  
M Trinchera ◽  
R Ghidoni ◽  
S Sonnino ◽  
G Tettamanti
Keyword(s):  
Fatty Acid ◽  
Intravenous Injection ◽  
Rat Liver ◽  
Sugar Residue ◽  
Gm1 Ganglioside ◽  
Chain Base ◽  
Neutral Glycosphingolipids ◽  
Long Chain Base ◽  
Ganglioside Biosynthesis ◽  
Long Chain

It was previously shown that sphingomyelin and gangliosides can be biosynthesized starting from sphingosine or sphingosine-containing fragments which originated in the course of GM1 ganglioside catabolism. In the present paper we investigated which fragments were specifically re-used for sphingomyelin and ganglioside biosynthesis in rat liver. At 30 h after intravenous injection of GM1 labelled at the level of the fatty acid ([stearoyl-14C]GM1) or of the sphingosine ([Sph-3H]) moiety, it was observed that radioactive sphingomyelin was formed almost exclusively after the sphingosine-labelled-GM1 administration. This permitted the recognition of sphingosine as the metabolite re-used for sphingomyelin biosynthesis. Conversely, gangliosides more complex than GM1 were similarly radiolabelled after the two treatments, thus ruling out sphingosine re-utilization for ganglioside biosynthesis. For the identification of the lipid fragment re-used for ganglioside biosynthesis, we administered to rats neutral glycosphingolipids (galactosylceramide, glucosylceramide and lactosylceramide) each radiolabelled in the sphingosine moiety or in the terminal sugar residue. Thereafter we compared the formation of radiolabelled gangliosides in the liver with respect to the species administered and the label location. After galactosylceramide was injected, no radiolabelled gangliosides were formed. After the administration of differently labelled glucosylceramide, radiolabelled gangliosides were formed, regardless of the position of the label. After lactosylceramide administration, the ganglioside fraction became more radioactive when the long-chain-base-labelled precursors were used. These results suggest that glucosylceramide, derived from glycosphingolipid and ganglioside catabolism, is recycled for ganglioside biosynthesis.

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