Lipid alterations and their reversion in the central nervous system of growing rats deficient in essential fatty acids

Lipids ◽  
1971 ◽  
Vol 6 (6) ◽  
pp. 378-387 ◽  
Author(s):  
C. Galli ◽  
H. B. White ◽  
R. Paoletti
Keyword(s):  
Fatty Acids ◽  
Central Nervous System ◽  
Nervous System ◽  
Essential Fatty Acids ◽  
Growing Rats ◽  
The Central Nervous System

scholarly journals Biological Chemistry in Intermediate Lipid Metabolism Disorder

2019 ◽  
Vol 70 (7) ◽  
pp. 2647-2651
Author(s):  
Alina Plesea Condratovici ◽  
Alina Mihaela Elisei ◽  
Decebal Vasincu ◽  
Iulian Dan Cuciureanu ◽  
Aurel Nechita ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Central Nervous System ◽  
Nervous System ◽  
Abdominal Cavity ◽  
Intestinal Wall ◽  
Pathological Process ◽  
The Body ◽  
Lipid Metabolism Disorder ◽  
Fat Deposits ◽  
The Central Nervous System

Any pathological process is accompanied by quantitative and qualitative changes in metabolism, which is the main form of life manifestation. Metabolism disorders (it is the permanent exchange of substances between the body and the environment) arise if the activity of the central nervous system is affected; the trophic function of the nervous system directs nutrition and metabolism. In this function, the coordinating role belongs to the central nervous system and is made by means of the endocrine glands. Lipids introduced into the body are digested mainly with the help of the pancreatic and intestinal juice and are resorbed through the walls of the small intestine. Even in the intestinal wall, the re-synthesis of fatty acids and glycerine fat occurs. A certain amount of neutral fat is probably resorbed without being split into fatty acids and glycerine. Fats are mainly resorbed through the lymphatic system, in part (about 30%) by means of the portal vein system; the entire fat emulsion penetrates into the blood and its main mass is deposited in certain fat deposits: the adipose subcutaneous cell tissue, the epiploon and the mesenterium of the abdominal cavity, as well as in the fatty layers of the various organs. In fat deposits, processes of lipid formation from carbohydrates and of transformation of higher fatty acids can occur. Lipids from fat deposits are subject to oxidation, especially at the liver level.

scholarly journals Omega – 3 fatty acids in schizophrenia – part I: importance in the pathophysiology of schizophrenia

2016 ◽  
Vol 17 (3) ◽  
pp. 198-213
Author(s):  
Joanna Róg ◽  
Hanna Karakuła-Juchnowicz
Keyword(s):  
Fatty Acids ◽  
Nervous System ◽  
Essential Fatty Acids ◽  
Dry Weight ◽  
Omega 3 ◽  
Metabolic Complications ◽  
The Central Nervous System ◽  
David Horrobin ◽  
The Brain

AbstractDespite the increasing offer of antipsychotic drugs, the effectiveness of pharmacotherapy in schizophrenia is still unsatisfactory. Drug resistance, lack of complete remission and the increasing risk of metabolic complications are the reasons why the new forms of therapy in schizophrenia among which unsaturated essential fatty acids omega 3 (EFAs ω-3) affecting the proper functioning of nervous system, are mentioned, are being looked for.Fatty acids represent 50-60% of the dry weight of the brain and diet is one of the factors that influence the value of each of the fat fractions in the neuron membranes. Patients with schizophrenia tend to have irregular nutritional status concerning essential fatty acids ω-3, which might result from metabolic disorders or irregular consumption of fatty acids.Apart from being a review of the literature on this subject, this very paper characterizes essential fatty acids ω-3, their metabolism, the most important sources in the diet and the opinions of experts in the field about the recommended intake. It pays attention to the role of essential fatty acids in both the structure and functioning of the central nervous system is, as well as their role in the pathophysiology of schizophrenia, with particular emphasis on the membrane concept by David Horrobin. The assessment of the errors in consumption and metabolism of essential fatty acids are described as well.The evidence was found both in epidemiological and modeling studies. It supports the participation of EFAs in etiopathogenesis and pathophysiology of schizophrenia. Further research is needed, both observational and interventional, as to the role of essential fatty acids ω-3 in the functioning of the CNS as well as the development and course of schizophrenia.

scholarly journals A biophysical study on molecular physiology of the uncoupling proteins of the central nervous system

2015 ◽  
Vol 35 (4) ◽  
Author(s):  
Tuan Hoang ◽  
Miljan Kuljanin ◽  
Matthew D. Smith ◽  
Masoud Jelokhani-Niaraki
Keyword(s):  
Escherichia Coli ◽  
Fatty Acids ◽  
Central Nervous System ◽  
Nervous System ◽  
Recombinant Protein Expression ◽  
Uncoupling Proteins ◽  
Molecular Physiology ◽  
Biophysical Study ◽  
The Central Nervous System ◽  
Self Association

Uncoupling proteins (UCP)2, UCP4 and UCP5 transport protons across the inner membrane of mitochondria in the central nervous system (CNS). Novel recombinant protein expression allowed expression of UCPs in Escherichia coli membranes. Functional neuronal UCPs formed multimers in membranes and interacted with various fatty acids (FAs) to transport protons. Self-association and unique ion transport properties of UCPs distinguish their physiological roles in the CNS.

scholarly journals Serotonin Promotes Serum Albumin Interaction with the Monomeric Amyloid β Peptide

2021 ◽  
Vol 22 (11) ◽  
pp. 5896
Author(s):  
Ekaterina A. Litus ◽  
Alexey S. Kazakov ◽  
Evgenia I. Deryusheva ◽  
Ekaterina L. Nemashkalova ◽  
Marina P. Shevelyova ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Central Nervous System ◽  
Nervous System ◽  
Serum Albumin ◽  
Quaternary Structure ◽  
Amyloid Β ◽  
Resonance Spectroscopy ◽  
Amyloid Β Peptide ◽  
Structural Differences ◽  
The Central Nervous System

Prevention of amyloid β peptide (Aβ) deposition via facilitation of Aβ binding to its natural depot, human serum albumin (HSA), is a promising approach to preclude Alzheimer’s disease (AD) onset and progression. Previously, we demonstrated the ability of natural HSA ligands, fatty acids, to improve the affinity of this protein to monomeric Aβ by a factor of 3 (BBRC, 510(2), 248–253). Using plasmon resonance spectroscopy, we show here that another HSA ligand related to AD pathogenesis, serotonin (SRO), increases the affinity of the Aβ monomer to HSA by a factor of 7/17 for Aβ40/Aβ42, respectively. Meanwhile, the structurally homologous SRO precursor, tryptophan (TRP), does not affect HSA’s affinity to monomeric Aβ, despite slowdown of the association and dissociation processes. Crosslinking with glutaraldehyde and dynamic light scattering experiments reveal that, compared with the TRP-induced effects, SRO binding causes more marked changes in the quaternary structure of HSA. Furthermore, molecular docking reveals distinct structural differences between SRO/TRP complexes with HSA. The disintegration of the serotonergic system during AD pathogenesis may contribute to Aβ release from HSA in the central nervous system due to impairment of the SRO-mediated Aβ trapping by HSA.

The effect of long-term lactobacilli (lactic acid bacteria) enteral treatment on the central nervous system of growing rats

2009 ◽  
Vol 20 (9) ◽  
pp. 677-684 ◽  
Author(s):  
Galyna Ushakova ◽  
Olexandr Fed'kiv ◽  
Olena Prykhod'ko ◽  
Stefan Pierzynowski ◽  
Danuta Kruszewska
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Growing Rats ◽  
The Central Nervous System

scholarly journals Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life

2004 ◽  
Vol 44 (6) ◽  
pp. 509-538 ◽  
Author(s):  
Jean-Marc Alessandri ◽  
Philippe Guesnet ◽  
Sylvie Vancassel ◽  
Pierre Astorg ◽  
Isabelle Denis ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Central Nervous System ◽  
Nervous System ◽  
Polyunsaturated Fatty Acids ◽  
System Evolution ◽  
Nervous System Evolution ◽  
The Central Nervous System
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