The peroxisome proliferator-activated receptor gamma agonist rosiglitazone inhibits growth and downregulates Bcl-2 gene expression in human follicular thyroid cancer cells

2004 ◽  
Vol 11 (S2) ◽  
pp. S103-S103
Author(s):  
W. T. Shen ◽  
T. S. Wong ◽  
M. G. Wong ◽  
E. Kebebew ◽  
Q. Y. Duh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Cancer ◽  
Cancer Cells ◽  
Peroxisome Proliferator ◽  
Follicular Thyroid Cancer ◽  
Peroxisome Proliferator Activated Receptor ◽  
Thyroid Cancer Cells

scholarly journals The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells

2007 ◽  
Vol 67 (14) ◽  
pp. 6956-6964 ◽  
Author(s):  
Nagako Akeno-Stuart ◽  
Michelle Croyle ◽  
Jeffrey A. Knauf ◽  
Roberta Malaguarnera ◽  
Donata Vitagliano ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Cancer ◽  
Cancer Cells ◽  
Medullary Thyroid Cancer ◽  
Kinase Inhibitor ◽  
Medullary Thyroid ◽  
Calcitonin Gene ◽  
Thyroid Cancer Cells

Functional Thyrotropin Receptor Attenuates Malignant Phenotype of Follicular Thyroid Cancer Cells

Endocrine ◽  
2006 ◽  
Vol 30 (1) ◽  
pp. 129-138 ◽  
Author(s):  
S. Hoffmann ◽  
K. Maschuw ◽  
I. Hassan ◽  
A. Wunderlich ◽  
S. Lingelbach ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Thyrotropin Receptor ◽  
Follicular Thyroid Cancer ◽  
Malignant Phenotype ◽  
Thyroid Cancer Cells

High doses of hydroxytyrosol induce apoptosis in papillary and follicular thyroid cancer cells

2016 ◽  
Vol 40 (2) ◽  
pp. 153-162 ◽  
Author(s):  
G. Toteda ◽  
S. Lupinacci ◽  
D. Vizza ◽  
R. Bonofiglio ◽  
E. Perri ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Follicular Thyroid Cancer ◽  
High Doses ◽  
Thyroid Cancer Cells

scholarly journals Microgravity Affects Thyroid Cancer Cells during the TEXUS-53 Mission Stronger than Hypergravity

2018 ◽  
Vol 19 (12) ◽  
pp. 4001 ◽  
Author(s):  
Sascha Kopp ◽  
Marcus Krüger ◽  
Johann Bauer ◽  
Markus Wehland ◽  
Thomas Corydon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Cancer ◽  
Cancer Cells ◽  
Sounding Rocket ◽  
Random Positioning Machine ◽  
Morphological Alterations ◽  
Endocrine Organs ◽  
Poorly Differentiated ◽  
Thyroid Cancer Cells

Thyroid cancer is the most abundant tumor of the endocrine organs. Poorly differentiated thyroid cancer is still difficult to treat. Human cells exposed to long-term real (r-) and simulated (s-) microgravity (µg) revealed morphological alterations and changes in the expression profile of genes involved in several biological processes. The objective of this study was to examine the effects of short-term µg on poorly differentiated follicular thyroid cancer cells (FTC-133 cell line) resulting from 6 min of exposure to µg on a sounding rocket flight. As sounding rocket flights consist of several flight phases with different acceleration forces, rigorous control experiments are mandatory. Hypergravity (hyper-g) experiments were performed at 18g on a centrifuge in simulation of the rocket launch and s-µg was simulated by a random positioning machine (RPM). qPCR analyses of selected genes revealed no remarkable expression changes in controls as well as in hyper-g samples taken at the end of the first minute of launch. Using a centrifuge initiating 18g for 1 min, however, presented moderate gene expression changes, which were significant for COL1A1, VCL, CFL1, PTK2, IL6, CXCL8 and MMP14. We also identified a network of mutual interactions of the investigated genes and proteins by employing in-silico analyses. Lastly, µg-samples indicated that microgravity is a stronger regulator of gene expression than hyper-g.

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