Survival efficacy of adjuvant cytosine analog CS-682 treatment of human pancreatic cancer in an orthotopic metastatic model monitored by fluorescence whole-body imaging

2004 ◽  
Vol 11 (S2) ◽  
pp. S71-S72
Author(s):  
M. H. Katz ◽  
M. Bouvet ◽  
S. Takimoto ◽  
D. Spivack ◽  
A. R. Moossa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Human Pancreatic Cancer ◽  
Whole Body ◽  
Whole Body Imaging ◽  
Body Imaging

scholarly journals Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer

2015 ◽  
Vol 112 (52) ◽  
pp. 15850-15855 ◽  
Author(s):  
Jacob L. Houghton ◽  
Brian M. Zeglis ◽  
Dalya Abdel-Atti ◽  
Robert Aggeler ◽  
Ritsuko Sawada ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Human Monoclonal Antibody ◽  
Human Pancreatic Cancer ◽  
Whole Body ◽  
Imaging Agents ◽  
Whole Body Imaging ◽  
Human Pancreatic Cancer Cell ◽  
Nirf Imaging

Molecular imaging agents for preoperative positron emission tomography (PET) and near-infrared fluorescent (NIRF)-guided delineation of surgical margins could greatly enhance the diagnosis, staging, and resection of pancreatic cancer. PET and NIRF optical imaging offer complementary clinical applications, enabling the noninvasive whole-body imaging to localize disease and identification of tumor margins during surgery, respectively. We report the development of PET, NIRF, and dual-modal (PET/NIRF) imaging agents, using 5B1, a fully human monoclonal antibody that targets CA19.9, a well-established pancreatic cancer biomarker. Desferrioxamine (DFO) and/or a NIRF dye (FL) were conjugated to the heavy-chain glycans of 5B1, using a robust and reproducible site-specific (ss) labeling methodology to generate three constructs (ssDFO-5B1, ssFL-5B1, and ssdual-5B1) in which the immunoreactivity was not affected by the conjugation of either label. Each construct was evaluated in a s.c. xenograft model, using CA19.9-positive (BxPC3) and -negative (MIAPaCa-2) human pancreatic cancer cell lines. Each construct showed exceptional uptake and contrast in antigen-positive tumors with negligible nonspecific uptake in antigen-negative tumors. Additionally, the dual-modal construct was evaluated in an orthotopic murine pancreatic cancer model, using the human pancreatic cancer cell line, Suit-2. The ssdual-5B1 demonstrated a remarkable capacity to delineate metastases and to map the sentinel lymph nodes via tandem PET-computed tomography (PET/CT) and NIRF imaging. Fluorescence microscopy, histopathology, and autoradiography were performed on representative sections of excised tumors to visualize the distribution of the constructs within the tumors. These imaging tools have tremendous potential for further preclinical research and for clinical translation.

scholarly journals P2.11-21 Usefulness of Diffusion-Weighted Whole-Body Imaging with Background Suppression in the Postoperative Follow-up Period

2019 ◽  
Vol 14 (10) ◽  
pp. S800
Author(s):  
K. Suemori ◽  
M. Kataoka ◽  
D. Okutani ◽  
T. Fujita ◽  
I. Togami ◽  
...  
Keyword(s):  
Whole Body ◽  
Background Suppression ◽  
Whole Body Imaging ◽  
Body Imaging ◽  
Diffusion Weighted

scholarly journals Diffusion-weighted whole-body imaging with background body signal suppression/T2-weighted image fusion of gastrointestinal cancers

2016 ◽  
Vol 5 (1) ◽  
pp. 44-48 ◽  
Author(s):  
MINORU TOMIZAWA ◽  
FUMINOBU SHINOZAKI ◽  
KAZUNORI FUGO ◽  
TAKAFUMI SUNAOSHI ◽  
DAISUKE KANO ◽  
...  
Keyword(s):  
Image Fusion ◽  
Whole Body ◽  
Whole Body Imaging ◽  
Gastrointestinal Cancers ◽  
Body Imaging ◽  
Weighted Image ◽  
Diffusion Weighted ◽  
Signal Suppression

scholarly journals Small-animal whole-body imaging using a photoacoustic full ring array system

2011 ◽  
Author(s):  
Jun Xia ◽  
Zijian Guo ◽  
Andres Aguirre ◽  
Quing Zhu ◽  
Lihong V. Wang
Keyword(s):  
Small Animal ◽  
Whole Body ◽  
Whole Body Imaging ◽  
Body Imaging

Detection of Hemangiomas Using Whole-body Imaging with Technetium-99m Labeled RBCs

1986 ◽  
Vol 11 (10) ◽  
pp. 716-717 ◽  
Author(s):  
JEREMY J. HOLLERMAN ◽  
MARC A. BERNSTEIN ◽  
JERRY W. FROELICH ◽  
GEORGE SCHKUDOR
Keyword(s):  
Whole Body ◽  
Whole Body Imaging ◽  
Body Imaging ◽  
Technetium 99M

Dynamic contrast-enhanced (DCE) imaging: state of the art and applications in whole-body imaging

2021 ◽  
Author(s):  
Domenico Albano ◽  
Federico Bruno ◽  
Andrea Agostini ◽  
Salvatore Alessio Angileri ◽  
Massimo Benenati ◽  
...  
Keyword(s):  
State Of The Art ◽  
Whole Body ◽  
Whole Body Imaging ◽  
Body Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced
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