Determination of iodine in organic iodine compounds by the non-equilibrium isotopic exchange method

1977 ◽  
Vol 36 (1) ◽  
pp. 77-85 ◽  
Author(s):  
N. Ikeda ◽  
Y. Takahashi
Keyword(s):  
Isotopic Exchange ◽  
Exchange Method ◽  
Organic Iodine ◽  
Iodine Compounds ◽  
Non Equilibrium

scholarly journals Erratum

1968 ◽  
Vol 14 (6) ◽  
pp. 582-582
Keyword(s):  
Distilled Water ◽  
Serum Thyroxine ◽  
Organic Iodine ◽  
Final Volume ◽  
Iodine Compounds

Abstract The article "Determination of Organic Iodine Compounds in Serum: IV. A New Nonincineration Technic for Serum Thyroxine" by Vincent J. Pileggi and Gerald Kessler—Clin. Chem. 14, 339 (1968)—contains an error. On page 340, under Reagents, the preparation of the bromate-bromide reagent should read: Bromate-bromide reagent (0.1 M KBrO3, 0.6 M KBr) KBrO3, 1.67 gm., and KBr, 7.14 gui., are dissolved in distilled water, and the solution made to a final volume of 100 ml.

scholarly journals A New Type of Radiometric Analysis—Non-equilibrium Isotopic Exchange Method

RADIOISOTOPES ◽  
1969 ◽  
Vol 18 (6) ◽  
pp. 224-226 ◽  
Author(s):  
Nagao IKEDA ◽  
Kan KIMURA ◽  
Yasuko TAKAHASHI ◽  
Yoshiko FUJIKI
Keyword(s):  
Isotopic Exchange ◽  
Exchange Method ◽  
Radiometric Analysis ◽  
New Type ◽  
Non Equilibrium

Determination of Organic Iodine Compounds in Serum

1962 ◽  
Vol 8 (6) ◽  
pp. 647-653 ◽  
Author(s):  
Vincent J Pileggi ◽  
Richard J Henry ◽  
Milton Segalove ◽  
George C Hamill
Keyword(s):  
Serum Protein ◽  
Paper Chromatography ◽  
Solvent System ◽  
Organic Iodine ◽  
Iodine Compounds ◽  
System 2

Abstract RI — values of organic iodine compounds which interfere with the determination of serum protein-bound iodine (PBI) and butanol-extractable iodine (BEI) levels were obtained for the solvent system 2-butanol-4% NH4OH (3:1) utilizing descending paper chromatography. The feasibility of employing this system for identification of exogenous organic iodine in patients' sera was investigated. In general, the demonstration of these compounds or their metabolites was achieved only in sera obtained shortly after administration. This was due mainly to sensitivity limitations in the detection of the compounds on paper. Some data on the duration of interference with the PBI and BEI were also obtained for the radiopaque dyes Telepaque, Hypaque, Salipix, and Orabilex.

Determination of Organic Iodine Compounds in Serum

1968 ◽  
Vol 14 (4) ◽  
pp. 339-347 ◽  
Author(s):  
Vincent J Pileggi ◽  
Gerald Kessler
Keyword(s):  
Acetic Acid ◽  
Exchange Resin ◽  
Anion Exchange Resin ◽  
Direct Determination ◽  
Wet Digestion ◽  
Organic Iodine ◽  
Iodine Compounds ◽  
Dry Ashing ◽  
Dowex 1

Abstract Unidentified substances in acetic acid column eluates, obtained in the determination of serum thyroxine by column chromatography with the anion-exchange resin Dowex-1, prevented the direct determination of thyroxine by interference with the iodidecatalyzed ceric-arsenite reaction. Pretreatment of the eluates with Br2 or Cl2 eliminated the interference and permitted the direct assay of thyroxine by the ceric-arsenite system without incineration or wet digestion. Pretreatment with Br2 or Cl2 also significantly enhanced the catalytic activity of thyroxine, rendering its iodine nearly equivalent to inorganic iodide in the ceric-arsenite system. This nonincineration thyroxine assay is significantly more specific than methods that employ wet or dry ashing, because many organic iodine compounds used in diagnosis and therapy are not measured. A comparison of the nonincineration technic with the alkaline dry-ash method on 110 random serums revealed a mean difference of 0.13 µg./100 ml. (X = 4.5 µg./ 100 ml.), with the nonincineration technic yielding the higher result. This difference was found to be statistically significant (p< 0.001).

Click Chemistry Expedited Radiosynthesis: Sulfur [18F]fluoride Exchange of Aryl Fluorosulfates

2019 ◽  
Author(s):  
Qinheng Zheng ◽  
Hongtao Xu ◽  
Hua Wang ◽  
Wen-Ge Han Du ◽  
Nan Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Performance ◽  
Isotopic Exchange ◽  
Tumor Imaging ◽  
Radiochemical Yield ◽  
Exchange Method ◽  
Molar Activity ◽  
Positron Emission ◽  
Sulfur Fluoride

The lack of simple, efficient [<sup>18</sup>F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [<sup>18</sup>F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated <sup>18</sup>F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol<sup>–1</sup>) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [<sup>18</sup>F]fluorosulfate is demonstrated by the <i>in vivo</i> tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

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