A comparison betweenin vitro studies of protein lesions generated by brain electrodes and finite element model simulations

1999 ◽  
Vol 37 (6) ◽  
pp. 737-741 ◽  
Author(s):  
O. Eriksson ◽  
J. Wren ◽  
D. Loyd ◽  
K. Wårdell
Keyword(s):  
Finite Element ◽  
Finite Element Model ◽  
Element Model ◽  
Model Simulations

Biomechanical Comparison of Real World Concussive Impacts in Children, Adolescents, and Adults

2020 ◽  
Vol 142 (7) ◽  
Author(s):  
Lauren Dawson ◽  
David Koncan ◽  
Andrew Post ◽  
Roger Zemek ◽  
Michael D. Gilchrist ◽  
...  
Keyword(s):  
Finite Element ◽  
Finite Element Model ◽  
Brain Tissue ◽  
Dynamic Models ◽  
Element Model ◽  
Tissue Response ◽  
Model Simulations ◽  
Child Group ◽  
Adolescents And Adults ◽  
The Impact

Abstract Accidental falls occur to people of all ages, with some resulting in concussive injury. At present, it is unknown whether children and adolescents are at a comparable risk of sustaining a concussion compared to adults. This study reconstructed the impact kinematics of concussive falls for children, adolescents, and adults and simulated the associated brain tissue deformations. Patients included in this study were diagnosed with a concussion as defined by the Zurich Consensus guidelines. Eleven child, 10 adolescent, and 11 adult falls were simulated using mathematical dynamic models(MADYMO), with three ellipsoid pedestrian models sized to each age group. Laboratory impact reconstruction was conducted using Hybrid III head forms, with finite element model simulations of the brain tissue response using recorded impact kinematics from the reconstructions. The results of the child group showed lower responses than the adolescent group for impact variables of impact velocity, peak linear acceleration, and peak rotational acceleration but no statistical differences existed for any other groups. Finite element model simulations showed the child group to have lower strain values than both the adolescent and adult groups. There were no statistical differences between the adolescent and adult groups for any variables examined in this study. With the cases included in this study, young children sustained concussive injuries at lower modeled brain strains than adolescents and adults, supporting the theory that children may be more susceptible to concussive impacts than adolescents or adults.

Finite Element Model Simulations Associated With Hydraulic Fracturing

1982 ◽  
Vol 22 (02) ◽  
pp. 209-218 ◽  
Author(s):  
Sunder H. Advani ◽  
J.K. Lee
Keyword(s):  
Finite Element ◽  
Hydraulic Fracturing ◽  
Finite Element Model ◽  
Hydraulic Fracture ◽  
Element Model ◽  
In Situ Stress ◽  
Fracture System ◽  
Model Simulations ◽  
Fracture Fluid

Abstract Recently emphasis has been placed on the development and testing of innovative well stimulation techniques for the recovery of unconventional gas resources. The design of optimal hydraulic fracturing treatments for specified reservoir conditions requires sophisticated models for predicting the induced fracture geometry and interpreting governing mechanisms. This paper presents methodology and results pertinent to hydraulic fracture modeling for the U.S. DOE's Eastern Gas Shales Program (EGSP). The presented finite-element model simulations extend available modeling efforts and provide a unified framework for evaluation of fracture dimensions and associated responses. Examples illustrating the role of multilayering, in-situ stress, joint interaction, and branched cracks are given. Selected comparisons and applications also are discussed. Introduction Selection and design of stimulation treatments for Devonian shale wells has received considerable attention in recent years1-3. The production of natural gas from such tight eastern petroliferous basins is dependent on the vertical thickness of the organically rich shale matrix, its inherent fracture system density, anisotropy, and extent, and the communication-link characteristics of the induced fracture system(s). The investigation of stimulation techniques based on resource characterization, reservoir property evaluation, theoretical and laboratory model simulations, and field testing is a logical step toward the development of commercial technology for optimizing gas production and related costs. This paper reports formulations, methodology, and results associated with analytical simulations of hydraulic fracturing for EGSP. The presented model extends work reported by Perkins and Kern,4 Nordgren,5 Geertsma and DeKlerk,6 and Geertsma and Haafkens.7 The simulations provide a finite-element model framework for studying vertically induced fracture responses with the effects of multilayering and in-situ stress considered. In this context, Brechtel et al.,8 Daneshy,9 Cleary,10 and Anderson et al.11 have done recent studies addressing specific aspects of this problem. The use of finite-element model techniques for studying mixed-mode fracture problems encountered in dendritic fracturing and vertical fracture/joint interaction also is illustrated along with application of suitable failure criteria. Vertical Hydraulic Fracture Model Formulations Coupled structural fracture mechanics and fracture fluid response models for predicting hydraulically induced fracture responses have been reported previously.12,13 These simulations incorporate specified reservoir properties, in-situ stress conditions, and stimulation treatment parameters. One shortcoming of this modeling effort is that finite-element techniques are used for the structural and stress intensity simulations, while a finite-difference approach is used to evaluate the leakoff and fracture-fluid response in the vertical crack. A consistent framework for conducting all simulations using finite-element modeling is formulated here.

(Invited) Finite Element Model Simulations to Assist the Design of Microdevices Dedicated to the Localized Electroporation of Mouse Embryos

2014 ◽  
Vol 64 (16) ◽  
pp. 7-14 ◽  
Author(s):  
X. Zhao ◽  
E. Mazari ◽  
D. Suarez-Boomgaard ◽  
I. Migeotte ◽  
A. Perea-Gomez ◽  
...  
Keyword(s):  
Finite Element ◽  
Finite Element Model ◽  
Element Model ◽  
Mouse Embryos ◽  
Model Simulations
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