Melatonin: Pharmacological properties and clinical application

1999 ◽  
Vol 33 (8) ◽  
pp. 452-455
Author(s):  
N. I. Andreeva ◽  
V. V. Asnina ◽  
S. S. Liberman
Keyword(s):  
Clinical Application ◽  
Pharmacological Properties

Biochanin A from Chinese Medicine: An Isoflavone with Diverse Pharmacological Properties

2021 ◽  
pp. 1-21
Author(s):  
Jia Yan ◽  
Panda Qiu ◽  
Xinyu Zhang ◽  
Yuanyuan Zhang ◽  
Linjing Mi ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Clinical Application ◽  
Trifolium Pratense ◽  
Safety Evaluation ◽  
Therapeutic Use ◽  
Biochanin A ◽  
Drug Candidate ◽  
Pharmacological Properties ◽  
Biological Availability ◽  
Trifolium Pratense L

Biochanin A (BCA) is a dietary isoflavone, isolated from the leaves and stems of Trifolium pratense L and many other herbs of Chinese medicine. Recent findings indicated BCA as a promising drug candidate with diverse bioactive effects. On the purpose of evaluating the possibility of BCA in clinical application, this review is trying to provide a comprehensive summary of the pharmacological actions of BCA. The publications collected from PubMed, ScienceDirect, and Wiley databases were summarized for the last 10 years. Then, the potential therapeutic use of BCA on the treatment of various diseases was discussed according to its pharmacological properties, namely, anticancer, anti-inflammatory, anti-bacterial, anti-diabetic, and anti-obesity effects as well as neuroprotective, hepatoprotective, cardioprotective, and osteoprotective effects. BCA might mainly regulate the MAPK, PI3K, NRF2, and NF-kB pathways, respectively, to exert its bioactive effects. However, the limited definitive targets, poor biological availability, and insufficient safety evaluation might block the clinical application of BCA. This review may provide new insights for the development of BCA in the application of related diseases.

Prostatic bioregulatory polypeptide prostatilen: pharmacological properties and 30-year experience of clinical application in urology

2020 ◽  
Vol 10 (3) ◽  
pp. 243-258
Author(s):  
Igor V. Kuzmin ◽  
Sergey Yu. Borovets ◽  
Anatoliy G. Gorbachev ◽  
Salman Kh. Al-Shukri
Keyword(s):  
Clinical Application ◽  
Chronic Prostatitis ◽  
Inflammatory Diseases ◽  
Experimental Studies ◽  
Prostatic Hyperplasia ◽  
Pharmacological Properties ◽  
Therapeutic Action ◽  
High Biological Activity ◽  
Saint Petersburg ◽  
Medical University

The review summarizes the results of 30-year clinical application of the prostatic bioregulatory peptide Prostatilen. The data from experimental studies, testifying for the high biological activity of the drug is shown, the mechanisms of its therapeutic action are described. The review presents the results of clinical studies demonstrating the effectiveness and pathogenetic justification of the prescription of Prostatilen in the treatment of chronic prostatitis, benign prostatic hyperplasia, infectious and inflammatory diseases of the kidneys and urinary bladder, as well as of several other diseases. The experience of Prostatilen application in the urological clinic of First Pavlov Saint Petersburg State Medical University is shown.

Tinospora cordifolia (Giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies

2020 ◽  
Vol 21 (12) ◽  
pp. 1165-1175
Author(s):  
Pradeep Kumar ◽  
Madhu Kamle ◽  
Dipendra K. Mahato ◽  
Himashree Bora ◽  
Bharti Sharma ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Alternative Medicine ◽  
Clinical Application ◽  
Future Generations ◽  
Tinospora Cordifolia ◽  
Conservation Strategies ◽  
Pharmacological Properties ◽  
Anti Oxidant ◽  
Ancient Times ◽  
Anti Inflammatory

Tinospora cordifolia (Giloy) is a medicinal plant used in folk and Ayurvedic medicines throughout India since ancient times. All the parts of the plant are immensely useful due to the presence of different compounds of pharmaceutical importance belonging to various groups as alkaloids, diterpenoid lactones, glycosides, steroids, sesquiterpenoid, and phenolics. These compounds possess pharmacological properties, which make it anti-diabetic, antipyretic, anti-inflammatory, anti-oxidant, hepato-protective, and immuno-modulatory. However, due to the increasing population, there is an inadequate supply of drugs. Therefore, this review focuses on phytochemistry, ethnopharmacology, clinical application and its conservation strategies so that the plant can be conserved for future generations and utilized as alternative medicine as well as to design various pharmacologically important drugs.

Echocardiography. Clinical application in mitral stenosis

JAMA ◽  
1966 ◽  
Vol 195 (3) ◽  
pp. 161-166 ◽  
Author(s):  
B. L. Segal
Keyword(s):  
Clinical Application ◽  
Mitral Stenosis
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