Pentoxifylline tablets with inert matrix: Optimization of composition and study of general toxicity

1999 ◽  
Vol 33 (5) ◽  
pp. 271-273
Author(s):  
O. N. Pozharitskaya ◽  
G. E. Grinberg ◽  
V. A. Vainshtein
Keyword(s):  
Inert Matrix ◽  
Matrix Optimization ◽  
General Toxicity ◽  
Optimization Of Composition

scholarly journals Assessment of General Toxicity of the Glycyrrhiza New Variety Extract in Rats

Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1126
Author(s):  
Dong-Gu Kim ◽  
Jeonghoon Lee ◽  
Wonnam Kim ◽  
Hyo-Jin An ◽  
Jong-Hyun Lee ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Oral Dose ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
New Variety ◽  
General Toxicity ◽  
Normal Ranges ◽  
Target Organs ◽  
Adverse Effect Level ◽  
Tract Infections

The Glycyrrhiza radix (Licorice) is one of the most commonly used medicinal plants in Asian countries, such as China, India, and Korea. It has been traditionally used to treat many diseases, including cough, cold, asthma, fatigue, gastritis, and respiratory tract infections. A Glycyrrhiza new variety, Wongam (WG), has been developed by the Korea Rural Development Administration and revealed pharmacological effects. However, the potential adverse effects of WG have not been revealed yet. This study evaluates the general toxicity of the WG extract through a single and repeated oral dose toxicity study in Sprague-Dawley rats. After single oral dose administration, no significant toxicological changes or mortality was observed up to 5000 mg/kg. Over a 4-week repeated oral dose toxicity study, no adverse effects and target organs were observed up to 5000 mg/kg/day. Over a 13-week repeated oral dose toxicity study, no mortality or toxicological changes involving ophthalmology, water consumption, or hematology were observed up to 5000 mg/kg/day. Although other parameters were changed, the alterations in question were not considered toxicologically significant, since responses remained within normal ranges and were not dose-dependent. In conclusion, the no-observed-adverse-effect level (NOAEL) of WG was higher than 5000 mg/kg/day, and no target organs were identified in rats.

On the basic properties of an iron-based simulated cermet inert matrix fuel, synthesized by a dry route in oxidizing conditions

2006 ◽  
Vol 48 (6) ◽  
pp. 590-598 ◽  
Author(s):  
N. Kamel ◽  
H. Aït-Amar ◽  
Z. Kamel ◽  
N. Souami ◽  
S. Telmoune ◽  
...  
Keyword(s):  
Inert Matrix Fuel ◽  
Basic Properties ◽  
Inert Matrix ◽  
Iron Based

Processing of magnesia–pyrochlore composites for inert matrix materials

2007 ◽  
Vol 362 (2-3) ◽  
pp. 336-342 ◽  
Author(s):  
S.J. Yates ◽  
P. Xu ◽  
J. Wang ◽  
J.S. Tulenko ◽  
J.C. Nino
Keyword(s):  
Inert Matrix

Preparation of mesoporous zirconia microspheres as inert matrix

2016 ◽  
Vol 481 ◽  
pp. 66-72 ◽  
Author(s):  
Ting Guo ◽  
Chen Wang ◽  
Jinlong Lv ◽  
Tongxiang Liang
Keyword(s):  
Inert Matrix ◽  
Mesoporous Zirconia
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