Voltage-dependent inhibition of muscarinic cationic current in guinea pig ileal cells by the blocker SK&F 96365

2000 ◽  
Vol 32 (3) ◽  
pp. 216-216
Author(s):  
A. V. Zholos ◽  
Ya. D. Tsytsyura ◽  
I. B. Philyppov ◽  
M. F. Shuba ◽  
T. B. Bolton
Keyword(s):  
Guinea Pig ◽  
Cationic Current ◽  
Voltage Dependent ◽  
Dependent Inhibition ◽  
Muscarinic Cationic Current

scholarly journals Voltage-dependent inhibition of the muscarinic cationic current in guinea-pig ileal cells by SK&F 96365

2000 ◽  
Vol 129 (4) ◽  
pp. 695-702 ◽  
Author(s):  
A V Zholos ◽  
Ya D Tsytsyura ◽  
I B Philyppov ◽  
M F Shuba ◽  
T B Bolton
Keyword(s):  
Guinea Pig ◽  
Cationic Current ◽  
Voltage Dependent ◽  
Dependent Inhibition ◽  
Muscarinic Cationic Current

Preferential potentiation by hypotonic cell swelling of muscarinic cation current in guinea pig ileum

1997 ◽  
Vol 272 (1) ◽  
pp. C240-C253 ◽  
Author(s):  
Y. Waniishi ◽  
R. Inoue ◽  
Y. Ito
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Muscarinic Receptor ◽  
Time Course ◽  
Cell Swelling ◽  
Patch Clamp Technique ◽  
Cationic Current ◽  
Whole Cell Patch Clamp ◽  
Voltage Dependent ◽  
Hypotonic Cell Swelling

The effects of hypotonic cell swelling (HCS) on muscarinic receptor-activated cationic current in guinea pig ileal smooth muscle were investigated by the whole cell patch-clamp technique. With nystatin-perforated recording, reduced external tonicity from 312 to 262 mosM caused cell swelling but hardly affected the membrane currents activated by depolarization, such as outward-rectifying K and voltage-dependent Ca currents. In contrast, the inward current evoked by carbachol at -60 mV was greatly increased (approximately 50%) by the same extent of hypotonicity. This effect is likely to occur through potentiation of nonselective cation channels coupled to the muscarinic receptor (mNSCCs) and probably does not involve elevated intracellular Ca2+ concentration ([Ca2+]i), since neither removal of external Ca2+ nor [Ca2+]i buffering with 10 mM 1,2-bis-(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid significantly affected the results. Furthermore, the time course and degree of this potentiation closely matched those of video-microscopically monitored HCS. These results support the view that mechanosensitive modulation may be a powerful mechanism to regulate mNSCCs activity in gut smooth muscle, together with membrane potential and [Ca2+]i.

Effect of intracellular Ca2+ on muscarinic cationic current in guinea pig ileal smooth muscle cells

2000 ◽  
Vol 32 (3) ◽  
pp. 198-199 ◽  
Author(s):  
Ya. D. Tsytsyura ◽  
A. V. Zholos ◽  
M. F. Shuba ◽  
T. B. Bolton
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Cationic Current ◽  
Ileal Smooth Muscle Cells ◽  
Muscarinic Cationic Current

NO-mediated MaxiKCa channel activation produces relaxation of guinea pig aorta independently of voltage-dependent L-type Ca2+ channels

2000 ◽  
Vol 34 (3) ◽  
pp. 159-165 ◽  
Author(s):  
Yoshio Tanaka ◽  
Tomomi Igarashi ◽  
Hiroki Kaneko ◽  
Fumiko Yamaki ◽  
Yumi Mochizuki ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Channel Activation ◽  
Voltage Dependent ◽  
Ca2 Channels

scholarly journals Voltage-dependent inhibition of the Na+,K+ pump by tetraethylammonium

1998 ◽  
Vol 1372 (2) ◽  
pp. 289-300 ◽  
Author(s):  
Ursula Eckstein-Ludwig ◽  
Jürgen Rettinger ◽  
Larisa A. Vasilets ◽  
Wolfgang Schwarz
Keyword(s):  
Voltage Dependent ◽  
Dependent Inhibition
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