Cytoplasmic acidosis induces multiple conductance states in ATP-sensitive potassium channels of cardiac myocytes

1993 ◽  
Vol 136 (2) ◽  
pp. 169-179 ◽  
Author(s):  
Zheng Fan ◽  
Tetsushi Furukawa ◽  
Tohru Sawanobori ◽  
Jonathan C. Makielski ◽  
Masayasu Hiraoka
Keyword(s):  
Potassium Channels ◽  
Cardiac Myocytes ◽  
Conductance States ◽  
Multiple Conductance States

Pachymatisma johnstonii Extract Opens ATP-Sensitive Potassium Channels in Cardiac Myocytes of the Frog Heart

1994 ◽  
Vol 5 (6) ◽  
pp. 499-504 ◽  
Author(s):  
Martin-Pierre Sauviat ◽  
Marie-Thérèse Moré ◽  
Jean-François Verbist
Keyword(s):  
Potassium Channels ◽  
Cardiac Myocytes ◽  
Frog Heart

scholarly journals The Anchoring Protein SAP97 Is Crucial For The Surface Expression Of Shal Kv Potassium Channels And Their Regulation By CaMKII In Cardiac Myocytes

2009 ◽  
Vol 96 (3) ◽  
pp. 261a
Author(s):  
Saïd El-Haou ◽  
Elise Balse ◽  
Nathalie Neyroud ◽  
Bruno Gavillet ◽  
Hugues Abriel ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Cardiac Myocytes ◽  
Surface Expression ◽  
Anchoring Protein

Inhibition of ATP-Sensitive Potassium Channels in Cardiac Myocytes by the Novel Class III Antiarrhythmic Agent MS-551

1995 ◽  
Vol 77 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Donald K. Martin ◽  
Yutaka Nakaya ◽  
Kenneth R. Wyse ◽  
Jane A. Bursill ◽  
Paul D. West ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Cardiac Myocytes ◽  
Antiarrhythmic Agent ◽  
The Novel ◽  
Class Iii ◽  
Class Iii Antiarrhythmic Agent

scholarly journals Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating

2020 ◽  
Vol 21 (19) ◽  
pp. 7340
Author(s):  
Alessio Lissoni ◽  
Nan Wang ◽  
Timur Nezlobinskii ◽  
Maarten De Smet ◽  
Alexander V. Panfilov ◽  
...  
Keyword(s):  
Kinetic Studies ◽  
Open Probability ◽  
Transition Analysis ◽  
Transmembrane Pores ◽  
Gating Modifier ◽  
Conductance States ◽  
Multiple Conductance States ◽  
The Impact

Cx43 hemichannels (HCs) are electrically and chemically gated transmembrane pores with low open probability and multiple conductance states, which makes kinetic studies of channel gating in large datasets challenging. Here, we developed open access software, named HemiGUI, to analyze HC gating transitions and investigated voltage-induced HC opening based on up to ≈4000 events recorded in HeLa-Cx43-overexpressing cells. We performed a detailed characterization of Cx43 HC gating profiles and specifically focused on the role of the C-terminal tail (CT) domain by recording the impact of adding an EGFP tag to the Cx43 CT end (Cx43-EGFP) or by supplying the Cx43 HC-inhibiting peptide Gap19 that interferes with CT interaction with the cytoplasmic loop (CL). We found that Gap19 not only decreased HC opening activity to the open state (≈217 pS) but also increased the propensity of subconductance (≈80 pS) transitions that additionally became slower as compared to the control. The work demonstrates that large sample transition analysis allows detailed investigations on Cx43 HC gating and shows that Gap19 acts as a HC gating modifier by interacting with the CT that forms a crucial gating element.

scholarly journals Kv4 Potassium Channels Form a Tripartite Complex With the Anchoring Protein SAP97 and CaMKII in Cardiac Myocytes

2009 ◽  
Vol 104 (6) ◽  
pp. 758-769 ◽  
Author(s):  
Saïd El-Haou ◽  
Elise Balse ◽  
Nathalie Neyroud ◽  
Gilles Dilanian ◽  
Bruno Gavillet ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Cardiac Myocytes ◽  
Anchoring Protein
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