Determination of highly polar compounds in water samples around former ammunition plants

1997 ◽  
Vol 45 (1) ◽  
pp. 91-98 ◽  
Author(s):  
U. Lewin ◽  
L. Wennrich ◽  
J. Efer ◽  
W. Engewald
Keyword(s):  
Water Samples ◽  
Polar Compounds ◽  
Highly Polar Compounds ◽  
Ammunition Plants

Multi-residue Determination of Polar Veterinary Drugs in Livestock and Fishery Products by Liquid Chromatography/Tandem Mass Spectrometry

2015 ◽  
Vol 98 (1) ◽  
pp. 230-247 ◽  
Author(s):  
Maki Kanda ◽  
Takayuki Nakajima ◽  
Hiroshi Hayashi ◽  
Tsuneo Hashimoto ◽  
Setsuko Kanai ◽  
...  
Keyword(s):  
Polar Compounds ◽  
Veterinary Drugs ◽  
Sea Bream ◽  
Residue Determination ◽  
Chicken Muscle ◽  
Key Points ◽  
Liquid Chromatography Tandem Mass ◽  
Fishery Products ◽  
Highly Polar Compounds

Abstract Residues of 37 polar veterinary drugs belonging to six families (quinolones, tetracyclines, macrolides, lincosamides, sulfonamides, and others) in livestock and fishery products were determined using a validated LC-MS/MS method. There were two key points insample preparation. First, extraction was performed with two solutions of different polarity. Highly polar compounds were initiallyextracted with Na2EDTA-McIlvaine's buffer (pH 7.0). Medium polar compounds were then extracted from the same samples with acetonitrile containing 0.1% formic acid. Secondly, cleanup was performed using a single SPE polymercartridge. The first extracted solution was applied to the cartridge. Highly polar compounds were retained on the cartridge. Then, the second extracted solution was applied to the same cartridge. Both highly and medium polar compounds were eluted from the cartridge. This method satisfied the guideline criteria for 37 out of 37 drugs in swine muscle, chicken muscle, bovine muscle, prawn, salmon trout, red sea bream, milk, and honey; 35 out of 37 in egg; and 34 out of 37 in flounder. The LOQ ranged from 0.1 to 5 μg/kg. Residues were detected in 24 out of 110 samples and analyzed using the validated method.

scholarly journals Use of a Mixed Cationic-Reverse Phase Column for Analyzing Small Highly Polar Metabolic Markers in Biological Fluids for Multiclass LC-HRMS Method

2020 ◽  
Vol 10 (20) ◽  
pp. 7137
Author(s):  
Marco Roverso ◽  
Iole Maria Di Gangi ◽  
Gabriella Favaro ◽  
Paolo Pastore ◽  
Sara Bogialli
Keyword(s):  
High Selectivity ◽  
Biological Fluids ◽  
Polar Compounds ◽  
Reverse Phase ◽  
Experimental Conditions ◽  
Metabolic Markers ◽  
Low Concentrations ◽  
Polar Metabolites ◽  
Highly Polar Compounds

The determination of small highly polar metabolites at low concentrations is challenging when reverse-phase (RP) chromatography is used for multiclass analysis. A mixed cationic-RP column coupled to high-resolution tandem MS (HR-MS/MS) was tested for highly polar compounds in biological fluids, i.e., trimethylamine N-oxide (TMAO) and the isobaric molecules beta-methylamino-L-alanine (BMAA) and 2,4-diaminobutyric acid (DAB). The efficient retention and separation of the above compounds were obtained with common and MS-friendly RP conditions, reaching high selectivity and sensitivity. The method was firstly assessed in plasma and urine, showing good linearity in the range 50–1000 µg/L and 500–10,000 µg/L for TMAO and both BMAA and DAB, respectively. Excellent precision (RDS < 3%) and good accuracies (71–85%) were observed except for BMAA in plasma, whose experimental conditions should be specifically optimized. Preliminary tests performed on compounds with biological relevance and a wider range of polarities proved the effectiveness of this chromatographic solution, allowing the simultaneous analysis of a larger panel of metabolites, from very small and polar compounds, like trimethylamine, to quite lipophilic molecules, such as corticosterone. The proposed LC-HRMS protocol is an excellent alternative to hydrophilic interaction liquid chromatography and ion-pairing RP chromatography, thus providing another friendly analytical tool for metabolomics.

The application of isotopically labeled analogues for the determination of small organic compounds by GC/MS with selected ion monitoring

2020 ◽  
Vol 12 (30) ◽  
pp. 3854-3864
Author(s):  
Magda Caban ◽  
Piotr Stepnowski
Keyword(s):  
Stable Isotope ◽  
Bisphenol A ◽  
Organic Compounds ◽  
Water Samples ◽  
Polar Compounds ◽  
Selected Ion Monitoring ◽  
Internal Standards

The study show the limitations and advantages of the use of stable isotope labeled internal standards (SILISs) for the quantification of small polar compounds (ibuprofen, diclofenac, metoprolol, bisphenol A, estradiol) in water samples by GC/MS (SIM).

Layer-by-layer coated molecular-imprinted solid-phase microextraction fibers for the determination of polar compounds in water samples

RSC Advances ◽  
2016 ◽  
Vol 6 (96) ◽  
pp. 94098-94104 ◽  
Author(s):  
Maosheng Zhang ◽  
Jiarong Huang
Keyword(s):  
Water Samples ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Polar Compounds ◽  
Selective Extraction ◽  
Layer By Layer ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

In this study, the selective extraction of polar compound in water samples was reported using molecular-imprinted solid-phase microextraction (MISPME) combined with dispersive liquid–liquid microextraction (DLLME) within situderivatization.

Smartphone Calibration for Crowd-Sourced Determination of the Presence of Cyanobacteria in Water Samples

2018 ◽  
Vol 2018 (12) ◽  
pp. 405-1-405-7
Author(s):  
Katherine Carpenter ◽  
Anthony Vodacek ◽  
Susan Farnand
Keyword(s):  
Water Samples
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