Studies on intranasal absorption of new formulation of 1–34 PTH in healthy volunteers

1996 ◽  
Vol 6 (S1) ◽  
pp. 269-269 ◽  
Author(s):  
M. Nomura ◽  
T. Okuno
Keyword(s):  
Healthy Volunteers ◽  
Intranasal Absorption ◽  
New Formulation

scholarly journals Pharmacokinetics of diltiazem hydrochloride delay-onset sustained-release pellet capsules in healthy volunteers

2013 ◽  
Vol 49 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Xi-Qing Yan ◽  
Zhi-Gang Chen ◽  
Rong-Liang Wang ◽  
Jun Yang ◽  
Fang Ai ◽  
...  
Keyword(s):  
Controlled Release ◽  
Oral Dose ◽  
Sustained Release ◽  
Healthy Volunteers ◽  
Single Oral Dose ◽  
High Performance ◽  
Reversed Phase ◽  
Pharmacokinetic Parameters ◽  
Diltiazem Hydrochloride ◽  
New Formulation

The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not been reported, although it is very important to clinical use. In this paper, we investigated the PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules and the food influence in Chinese healthy volunteers. The PK parameters indicated that the diltiazem hydrochloride delay-onset sustained-release pellet capsules appeared marked characteristics of delayed and controlled release. An opened-label, randomized and parallel clinical trial was conducted in 36 Chinese healthy volunteers with single oral dose (90 mg, 180 mg or 270 mg) and a multiple oral dose (90 mg d-1×6 d) administration. The effect of food on the PK of one single oral dose (360 mg) was investigated in 24 healthy Chinese volunteers. Plasma diltiazem concentration was determined by reversed-phase high-performance liquid chromatography (RP-HPLC) and the main pharmacokinetic parameters were analyzed by PKSolver (Ver 2.0). All clinical studies were conducted in the Clinical Pharmacological Center (No. JDX1999064) of Xiangya Hospital Affiliated Central South University, China. The PK parameters suggested that the new formulation had marked characteristics of delayed and controlled release of diltiazem, and food intake did not alter significantly diltiazem pharmacokinetic parameters.

PTL401, a New Formulation Based on Pro-Nano Dispersion Technology, Improves Oral Cannabinoids Bioavailability in Healthy Volunteers

2018 ◽  
Vol 107 (5) ◽  
pp. 1423-1429 ◽  
Author(s):  
Jacob Atsmon ◽  
Irina Cherniakov ◽  
Dvora Izgelov ◽  
Amnon Hoffman ◽  
Abraham J. Domb ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
New Formulation

Stereoselective pharmacokinetics of S-salbutamol after administration of the racemate in healthy volunteers

1999 ◽  
Vol 13 (6) ◽  
pp. 1230 ◽  
Author(s):  
B Schmekel ◽  
I Rydberg ◽  
B Norlander ◽  
K.n Sjöswärd ◽  
J Ahlner ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Stereoselective Pharmacokinetics

Estimation of 15O PET in healthy volunteers with automated ROI analysis by FineSRT

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S673-S673
Author(s):  
Ryo Takeuchi ◽  
Keiichi Matsumoto ◽  
Setsu Sakamoto ◽  
Yuhji Nakamoto ◽  
Michio Senda
Keyword(s):  
Healthy Volunteers
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