Intermittent cyclic etidronate increases bone mass in the elderly

1996 ◽  
Vol 6 (S1) ◽  
pp. 236-236
Author(s):  
D. L. Kendler ◽  
K. Barnebt ◽  
A. Liu ◽  
L. Dian
Keyword(s):  
Bone Mass ◽  
The Elderly ◽  
Cyclic Etidronate

Determinants of low bone mass in the elderly

1990 ◽  
Vol 10 (3) ◽  
pp. S306 ◽  
Author(s):  
C.Conrad Johnston
Keyword(s):  
Bone Mass ◽  
The Elderly ◽  
Low Bone Mass

scholarly journals Correlation of ADIPOQ Gene Single Nucleotide Polymorphisms with Bone Strength Index in Middle-Aged and the Elderly of Guangxi Mulam Ethnic Group

2021 ◽  
Vol 18 (24) ◽  
pp. 13034
Author(s):  
Min Zhou ◽  
Ning Ning ◽  
Yueming Jiang ◽  
Michael Aschner ◽  
Xiufeng Huang ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Strength ◽  
Susceptibility Gene ◽  
Subcutaneous Fat ◽  
The Elderly ◽  
Strength Index ◽  
Middle Aged ◽  
Single Nucleotide ◽  
Adipoq Gene ◽  
Bone Strength Index

Background: Osteoporosis (OP) is a common orthopedic disease in the elderly, and Adiponectin (ADIPOQ) is closely related to bone metabolism. Objective: To determine the relationship between five single nucleotide polymorphism (SNP) loci in the ADIPOQ gene and osteoporosis in middle-aged and elderly Mulam subjects in Hechi, Guangxi. Methods: This case-control study included 297 middle-aged and elderly Mulam subjects with normal bone mass, 49 subjects with reduced bone mass, and 38 subjects with osteoporosis. Five loci (rs266729, rs1063539, rs2241766, rs3774261, rs710445) of the ADIPOQ in the Mulam subjects were genotyped using SNP with multiple-base extension. Results: The bone strength index (SI) of middle-aged and elderly Mulam subjects showed an overall decreasing trend when the subjects were older. Age, muscle mass, and subcutaneous fat content were the main factors influencing the SI in Mulam subjects. The GC genotype of rs266729 and the GA and GG genotypes of rs710445 were significantly correlated with risk of bone loss (p < 0.05). rs2241766 and rs1063539 showed strong LD (D’ > 0.8, r2 > 0.33). rs710445 and rs266729 loci and rs3774261 and rs2241766 loci showed complete LD (D’ = 1). Conclusions: The GC genotype at rs266729 of the ADIPOQ gene, the GA and GG genotypes at rs710445, and the haplotypes CCGAA and GGTAG correlated with osteoporosis (p < 0.05). The allele C of rs1063539, rs266729 and rs710445 may afford protection for osteoporosis. The allele G may be the genetic susceptibility gene for osteoporosis, increasing the risk of osteoporosis.

scholarly journals THE ERGONOMIC ELDERLY GYM IMPROVING PHYSICAL FITNESS AND INCREASING THE BONE MASS OF THE ELDERLY

2020 ◽  
Vol 1 (2) ◽  
pp. 1
Author(s):  
N.N. Ariati ◽  
N. Adiputra ◽  
K. Tirtayasa ◽  
I.P.G. Adiatmika ◽  
A. Pangkahila ◽  
...  
Keyword(s):  
Bone Mass ◽  
Physical Fitness ◽  
The Elderly ◽  
T Test ◽  
Wilcoxon Test ◽  
Whole Body ◽  
Distribution Data ◽  
Paired Sample ◽  
Significant Difference ◽  
The Difference

The public is increasingly aware of the importance of exercise for the elderly because exercise is an option to reduce complaints due to setbacks and improve the health of the elderly. In fact the implementation in the field is often wrong as in Banjar Benaya which implements routine exercises only once a week with a duration less than 30 minutes, does not pay attention to nutritional needs, does not use sports clothing, and displays that are not clear. The measurement of elderly physical fitness is still relatively low. Based on these problems, improvements were made to the application of ergonomic elderly gymnastics due to improve elderly’s physical fitness and increase the bone mass.  This study used a treatment by subject design conducted in April 2017-August 2018. The target population was all elderly in Denpasar and the affordable population was determined by multistage random sampling then selected Banjaya Benaya Peguyangan Village with a sample of 20 people who met the inclusion criteria. The data collection were physical fitness and bone mass. The difference in treatment effects were analyzed using a Paired Sample t-Test with α = 0.05 for data with normal distribution and Wilcoxon test, α = 0.05 for data with abnormal distribution. Data showed that there were differences in physical fitness improvement in Period I and Period II after 8 weeks of gymnastics at 43.43% with very bad categories being bad, the difference in increase in whole body bone mass was 16.76% and leg bone mass 68.67%. Analysis of Paired Sample-t-Test physical fitness data and Wilcoxon test for bone mass data in Period I and Period II after gymnastics for 8 weeks, found that there was a significant difference (p <0.05). It can be concluded that ergonomic elderly gym can significantly improve physical fitness and increase bone mass of the elderly. It is recommended that the elderly continue to exercise with a duration of 30-45 minutes, the frequency of 3 times a week to maintain elderly’s physical fitness.

Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture

2019 ◽  
Vol 30 (5) ◽  
pp. 1071-1078 ◽  
Author(s):  
B.-J. Kim ◽  
H. J. Yoo ◽  
S. J. Park ◽  
M. K. Kwak ◽  
S. H. Lee ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Fatty Acid ◽  
Hip Fracture ◽  
Bone Mass ◽  
The Elderly ◽  
Trap 5B

scholarly journals Nutrition and osteoporosis prevention and treatment

2020 ◽  
Vol 7 (4) ◽  
pp. 3709-3720
Author(s):  
Jalal Hejazi ◽  
Ali Davoodi ◽  
Mohammadreza Khosravi ◽  
Meghdad Sedaghat ◽  
Vahideh Abedi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Mass ◽  
Vitamin K ◽  
Significant Role ◽  
Bone Health ◽  
The Elderly ◽  
Calcium Deficiency ◽  
Osteoporosis Prevention ◽  
Prevention And Treatment ◽  
Good Nutrition

Introduction: Osteoporosis falls among the major general health issues, specifically in the elderly, and is a widespread disease these days. According to various studies, good nutrition plays a significant role in osteoporosis prevention and treatment. The aim of this study was to conduct an extensive literature review on the effects of different nutrients to understand how macronutrients, micronutrients, and non-nutritive substances affect bone health. Methodology: To find relevant studies, the main keyword “osteoporosis” was searched in combination with “zinc,” “vitamin K,” “phosphorus,” “vitamin D,” “calcium,” “lipid,” “protein,” and “phytoestrogens” in PubMed (MEDLINE), Web of Science, SID, and Iran Medex databases. Findings: The most important element for bone health is calcium, which has a direct link to the bone mass density (BMD). In the case of calcium deficiency, high phosphorus content can damage bone tissue. The acceptable ratio of phosphorus to calcium is 0.5-1.5:1. Vitamin D is another important nutrient for bones; serum levels of vitamin D less than 20 ng/ml reduce bone density and increase the risk of fracture. High protein intake results in calcium excretion and loss of bone mass. In addition, calcium deficiency increases the risk of osteoporosis, specifically in the elderly. According to the literature, there is an inverse correlation between saturated fats and BMD. Vitamin K and magnesium deficiencies are correlated with BMD reduction and increased risk of osteoporosis. Copper and zinc are used as co-factors in the formation of collagen and elastin, and in mineralization of bone. As a result, deficiency of these elements may disrupt the process of incorporating minerals into the bone matrix. Conclusion: Good nutrition may play a significant role in osteoporosis prevention and treatment. Indeed, a healthy diet containing calcium (1,200 mg/day); vitamin D (600 IU); and certain amounts of protein, magnesium, and vitamin K can contribute greatly to bone health.

The influence of bone cells on the formation, and mineralization, of bone matrix

1984 ◽  
Vol 304 (1121) ◽  
pp. 453-454 ◽  
Keyword(s):  
Bone Mass ◽  
Bone Cells ◽  
Good Reason ◽  
Bone Matrix ◽  
Adult Life ◽  
Organic Matrix ◽  
The Elderly ◽  
Western World ◽  
Hospital Organization ◽  
Underlying Mechanisms

The Western World today faces a new and alarming epidemic-osteoporosis, i.e. a loss of bone mass affecting the elderly (Lane & Vigorita 1983). It has taken us by surprise. We do not understand its cause and therefore we have at present no cure. The osteoporosis may be so severe that our bones fracture for no good reason. In youth and early adult life we successfully mineralize the organic matrix of our skeletons. Inevitably as we pass from middle to old age we may suffer a loss of bone mass that affects both mineral and matrix. This skeletal deterioration varies in severity in different individuals. There is no satisfactory explanation of why it occurs and w hat the underlying mechanisms involved are; nor is it known what can be done to prevent or cure it. Hospital organization here in England is disorganized because beds are occupied by elderly people with broken bones (Dix 1983). Chemists and biologists face a double challenge. First, why and how does the matrix of the bone mineralize? Secondly, why, with increasing age, is there a deterioration both in matrix and in mineralization?

scholarly journals Mandibular Bone Mineral Density to predict Skeletal Osteoporosis: A Literature Review

2016 ◽  
Vol 02 (02) ◽  
pp. 096-101
Author(s):  
Sweta Pisulkar ◽  
Gajanan Pisulkar ◽  
Ashok Pakhan ◽  
Surekha Godbole ◽  
Trupti Dahane
Keyword(s):  
Literature Review ◽  
Bone Mass ◽  
Treatment Planning ◽  
Structural Changes ◽  
The Elderly ◽  
Disease Entity ◽  
Mineral Density ◽  
Mandibular Bone ◽  
The Usa ◽  
Skeletal Bone

AbstractUntil and unless the disease is recognized as a disease entity, a little progress has been made in understanding its etiology and in developing a predictable treatment planning, restoration, and prevention of the tissues. In a process carried out to study a disease entity, whether it be cardiac disease, dental caries, or periodontal disease, it is helpful to study its pathology (the gross and microscopic structural changes of the disease), its pathophysiology (the mechanisms or disordered functions of the disease), its pathogenesis (the life history), and its epidemiology (the worldwide prevalence of the disease and various interrelated factors). The ultimate aim of such researches is the better understanding of the etiology and pathogenesis of the disease, and thereby with such understanding leading to a predictable treatment planning and ultimately the prevention or control of these factors. Osteoporosis is a major health entity affecting the elderly population and thereby resulting in approximately 1.3 million spontaneous fractures in the USA every year. The above clinical condition is a deficiency of bone mass, or skeletal osteopenia, to that level where bone cannot provide adequate mechanical support. Many of the reported studies used inadequate measures of both skeletal and mandibular bone in evaluating their possible relationships. This literature review attempts to determine relationships between the total skeletal bone mass and bone mass of the mandible in the population suffering with osteoporosis.

scholarly journals Low bone mass in children and adolescents

2006 ◽  
Vol 50 (4) ◽  
pp. 775-782 ◽  
Author(s):  
João Lindolfo C. Borges ◽  
Cynthia M.A. Brandão
Keyword(s):  
Bone Mass ◽  
Elderly Population ◽  
The Elderly ◽  
Bone Fragility ◽  
Childhood And Adolescence ◽  
Low Bone Mass ◽  
Mass Measurements ◽  
Treatment Of Osteoporosis ◽  
Bone Mass Measurements

Osteoporosis is a disease characterized by low bone mass and micro architectural alterations of bone tissue leading to enhanced bone fragility and increased fracture risk. Although research in osteoporosis has focused mainly on the role of bone loss in the elderly population, it is becoming increasingly clear that the amount of bone that is gained during growth is also an important determinant of future resistance to fractures. Thus, considerable interest is being placed on defining preventive strategies that optimize the gain of bone mass during childhood and adolescence. Knowledge of the determinants accounting for the physiologic and genetic variations in bone accumulation in children will provide the best means toward the early diagnosis and treatment of osteoporosis. This article reviews the techniques available for bone mass measurements in children and the major determinants and diseases influencing bone accretion during childhood and adolescence.

Sign in / Sign up

Export Citation Format

Share Document