Age-related changes in plasma calcium-regulating hormones and bone mineralization in growing male and female rats

1996 ◽  
Vol 6 (S1) ◽  
pp. 211-211
Author(s):  
T. Okano ◽  
N. Tsugawa ◽  
M. Motboka ◽  
T. Kobayashi
Keyword(s):  
Bone Mineralization ◽  
Plasma Calcium ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Age Related ◽  
Age Related Changes

scholarly journals Differential Effects of Extended Exercise and Memantine Treatment on Adult Neurogenesis in Male and Female Rats

2018 ◽  
Author(s):  
Shaina P Cahill ◽  
John Darby Cole ◽  
Ru Qi Yu ◽  
Jack Clemans-Gibbon ◽  
Jason S Snyder
Keyword(s):  
Nmda Receptor ◽  
Cell Density ◽  
Adult Neurogenesis ◽  
Environmental Enrichment ◽  
Antidepressant Drugs ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Age Related ◽  
Males And Females

ABSTRACTThe creation of new neurons in adulthood has potential for treating a number of disorders that are characterized by neurodegeneration or impaired plasticity. Animal models of reduced neurogenesis, and studies of the volume and structural integrity of the hippocampus in humans, suggest a possible therapeutic role for adult neurogenesis in age-related cognitive decline, depression, and schizophrenia. Research over the past 20 years has identified a number of approaches for enhancing adult neurogenesis, such as exercise, NMDA receptor antagonists, antidepressant drugs and environmental enrichment. However, despite the chronic nature of many disorders that impact the human hippocampus, most animal studies have only examined the efficacy of neurogenic treatments over relatively short timescales (∼1 month or less). Additionally, investigations into the regulation of neurogenesis typically include only 1 sex, even though many disorders that affect the hippocampus differentially impact males and females. Here, we therefore tested whether two known pro-neurogenic treatments, running and the NMDA receptor antagonist, memantine, could lead to long-term increases in neurogenesis in male and female rats. We found that continuous access to a running wheel (cRUN) initially increased neurogenesis in both sexes, but effects were minimal after 1 month (both sexes) and completely absent after 5 months (males). Similarly, a single injection of memantine (sMEM) only transiently increased adult neurogenesis in both males and females. To determine whether extended increases in neurogenesis were possible with 2 months of RUN and MEM treatments, we subjected rats to interval running (iRUN), weekly memantine injections (mMEM), or combined treatments (iRUN-mMEM, mMEM-iRUN). We found that 2 months of iRUN increased DCX+ cell density in females but iRUN-mMEM treatment increased DCX+ cell density in males. However, analyses with thymidine analogs revealed that neurogenesis was minimally increased during the initial phases of the 2 month treatments. Collectively, our findings identify sex differences in the efficacy of neurogenic manipulations, which may be relevant for designing plasticity-promoting treatments that target the hippocampus.

scholarly journals Age-related Individual Behavioural Characteristics of Adult Wistar Rats

2021 ◽  
Author(s):  
Sergey Sudakov ◽  
Elena Alekseeva ◽  
Galina Nazarova ◽  
Valentina Bashkatova
Keyword(s):  
Motor Activity ◽  
Wistar Rats ◽  
Individual Characteristics ◽  
Female Rats ◽  
Related Individual ◽  
Male And Female Rats ◽  
Age Related ◽  
Behavioural Characteristics ◽  
Plus Maze ◽  
Age Related Changes

The aim of this work was to study age-related changes in the behaviour of adult Wistar rats using the open field (OF) and elevated plus maze (EPM) tests. Behavioural changes related to motor activity and anxiety were of particular interest. Results showed that as male and female rats progressed from 2 to 5 months of age there was a decrease in the level of motor and exploratory activities, and an increase in the level of anxiety. Age-related changes were dependent upon initial individual characteristics of behaviour. For example, animals that demonstrated high motor activity at 2 months become significantly less active by 5 months, and animals that showed a low level of anxiety at 2 months become more anxious by 5 months. Low-activity and high-anxiety rats did not show any significant age-related changes in OF and EPM tests from 2 to 5 months of age, except for a decrease in the number of rearings in EPM. Significant individual differences in the behaviour of rats in OF and EPM tests observed at 2 months were not apparent by 5 months.

scholarly journals The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats

2006 ◽  
Vol 47 (9) ◽  
pp. 2042-2048 ◽  
Author(s):  
Elena Thomàs-Moyà ◽  
Magdalena Gianotti ◽  
Ana M. Proenza ◽  
Isabel Lladó
Keyword(s):  
Caloric Restriction ◽  
Female Rats ◽  
Paraoxonase 1 ◽  
Male And Female ◽  
Male And Female Rats ◽  
Age Related
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