Cultured bone cells from osteoporotic patients show an altered response to mechanical loading

1996 ◽  
Vol 6 (S1) ◽  
pp. 85-85
Author(s):  
J G H Sterck ◽  
J Klein-Nulend ◽  
P Lips ◽  
E H Burger
Keyword(s):  
Mechanical Loading ◽  
Bone Cells ◽  
Altered Response ◽  
Cultured Bone Cells

Aging and the Osteogenic Response to Mechanical Loading

2001 ◽  
Vol 11 (s1) ◽  
pp. S137-S142 ◽  
Author(s):  
Wendy M. Kohrt
Keyword(s):  
Growth Factors ◽  
Bone Mass ◽  
Mechanical Loading ◽  
Bone Cells ◽  
Weight Bearing ◽  
Bone Modeling ◽  
Mineral Density ◽  
Increase Bone Mass ◽  
Age Related ◽  
Osteogenic Response

The osteogenic response to mechanical stress is blunted with aging. It has been postulated that this decline in responsiveness is related to (a) a limited ability to engender the strain necessary to reach the bone modeling threshold, due to decreased muscle mass and strength, and/or (b) a decline in certain hormones or growth factors that may interact with mechanical signals to change the sensitivity of bone cells to strain. There is reason to believe that both of these factors contribute to the reduced ability to increase bone mass through exercise with advancing age. Weight-bearing endurance exercise and resistance exercise have both been found to increase bone mass in older women and men. However, exercise training studies involving older individuals have generally resulted in increased bone mineral density only when the exercise is quite vigorous. There is also evidence that the osteogenic response to mechanical loading is enhanced by estrogens. Whether age-related changes in other factors (e.g., other hormones, growth factors, cytokines) also contribute to the reduced responsiveness of the aged skeleton to mechanical loading remains to be investigated.

Calcium uptake by cultured bone cells: The role of phosphate, calcitonin and 1,25-(OH)2 D3

1975 ◽  
Vol 21 (1) ◽  
pp. 332-338 ◽  
Author(s):  
A. Harell ◽  
I. Binderman ◽  
M. Guez
Keyword(s):  
Calcium Uptake ◽  
Bone Cells ◽  
Cultured Bone Cells

scholarly journals HOW DO BONE CELLS SENSE MECHANICAL LOADING?

2009 ◽  
Vol 44 (4) ◽  
pp. 299-305 ◽  
Author(s):  
Carlos Vinícius Buarque de Gusmão ◽  
William Dias Belangero
Keyword(s):  
Mechanical Loading ◽  
Bone Cells

Growth and Metabolism of Cultured Bone Cells Using Microcarrier and Monolayer Techniques

1994 ◽  
Vol &NA; (300) ◽  
pp. 254???258
Author(s):  
JIAN SHENG TANG ◽  
CHUNG FAYE CHAO ◽  
MAN KUAN AU
Keyword(s):  
Bone Cells ◽  
Cultured Bone Cells

Transplantation of cultured bone cells using combinations of scaffolds and culture techniques

Biomaterials ◽  
2003 ◽  
Vol 24 (13) ◽  
pp. 2277-2286 ◽  
Author(s):  
Toshimasa Uemura ◽  
Jian Dong ◽  
Yichao Wang ◽  
Hiroko Kojima ◽  
Takashi Saito ◽  
...  
Keyword(s):  
Bone Cells ◽  
Culture Techniques ◽  
Cultured Bone Cells

Abnormal cell calcium concentrations in cultured bone cells obtained from femurs of obese and noninsulin-dependent diabetic rats

1989 ◽  
Vol 44 (2) ◽  
pp. 131-137 ◽  
Author(s):  
J. Levy ◽  
I. Reid ◽  
L. Halstad ◽  
J. R. Gavin ◽  
L. V. Avioli
Keyword(s):  
Bone Cells ◽  
Diabetic Rats ◽  
Abnormal Cell ◽  
Cell Calcium ◽  
Cultured Bone Cells

Expression of the osteonectin gene potentially controlled by multiple Cis- and trans-acting factors in cultured bone cells

2009 ◽  
Vol 6 (10) ◽  
pp. 1127-1136 ◽  
Author(s):  
Pedro Dominguez ◽  
Kyomi Ibaraki ◽  
Pamela Gehron Robey ◽  
Theresa E. Hefferan ◽  
John D. Termine ◽  
...  
Keyword(s):  
Bone Cells ◽  
Cis And Trans ◽  
Cultured Bone Cells
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