Shor- and long-term effect of a calcium channel blocker, barnidipine, on renal hemodynamics in spontaneously hypertensive, diabetic rats

1997 ◽  
Vol 1 (3) ◽  
pp. 195-203
Author(s):  
Yue-Ling Qie ◽  
Kazo Kaizu ◽  
Kohei Uriu ◽  
Atsuo Sugita ◽  
Aki Matsuoka ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Diabetic Rats ◽  
Renal Hemodynamics ◽  
Term Effect ◽  
Spontaneously Hypertensive ◽  
Long Term Effect

Effect of nifedipine on calcium-induced contractions to potassium in the aorta and mesenteric arteries of spontaneously hypertensive and normotensive rats

1986 ◽  
Vol 64 (3) ◽  
pp. 310-314 ◽  
Author(s):  
M. S. Kannan ◽  
A. E. Seip ◽  
D. J. Crankshaw
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Effective Concentration ◽  
Mesenteric Arteries ◽  
Induced Responses ◽  
Shr Rats ◽  
Free Medium ◽  
Spontaneously Hypertensive ◽  
Calcium Dependence

Graded contractions to cumulative additions of calcium in the presence of KCl were obtained in strips of aorta and mesenteric arteries of normotensive (WKY) and spontaneously hypertensive (SHR) rats. In calcium-free medium, a maximally effective concentration of KCl produced a response that was larger in the mesenteric arteries (43–51% of control) than in the aorta (12–14% of control). The calcium channel blocker nifedipine (NFD, up to 10−7 M) did not significantly alter these calcium-insensitive responses. The Ca2+-induced responses were inhibited by NFD, in a concentration-dependent fashion, in both vessel types of WKY and SHR rats. The aortic responses were more sensitive to inhibition by NFD than the responses of mesenteric arteries. Moreover, the aortic responses of WKY were inhibited to a greater extent than those of the SHR. The results suggest: (a) a differential calcium dependence of contractions to KCl in the vessels studied; (b) that aortic responses are dependent on NFD-sensitive voltage-sensitive Ca2+ channels to a greater extent than the responses of mesenteric arteries; and (c) that hypertension results in a decreased sensitivity of the aorta Ca2+ channels to NFD.

Long-term effects of L- and N-type calcium channel blocker on uric acid levels and left atrial volume in hypertensive patients

2016 ◽  
Vol 31 (11) ◽  
pp. 1826-1833 ◽  
Author(s):  
Mitsuru Masaki ◽  
Toshiaki Mano ◽  
Akiyo Eguchi ◽  
Shohei Fujiwara ◽  
Masataka Sugahara ◽  
...  
Keyword(s):  
Uric Acid ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Left Atrial ◽  
Channel Blocker ◽  
Left Atrial Volume ◽  
Long Term Effects ◽  
Atrial Volume ◽  
Hypertensive Patients
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