Enhanced adhesion of endothelial cells onto a polypropylene hollow-fiber membrane by plasma discharge treatment and high inoculum cell density

2001 ◽  
Vol 4 (3) ◽  
pp. 220-225 ◽  
Author(s):  
Mutsumi Takagi ◽  
Toshihide Haraguchi ◽  
Hisanori Kawai ◽  
Kouji Shiwaku ◽  
Takeomi Inoue ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Density ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Plasma Discharge ◽  
Fiber Membrane ◽  
Discharge Treatment ◽  
High Inoculum

Human endothelial cells hollow fiber membrane bioreactor as a model of the blood vessel for in vitro studies

2016 ◽  
Vol 19 (3) ◽  
pp. 270-277
Author(s):  
Anna Ciechanowska ◽  
Piotr Ladyzynski ◽  
Grazyna Hoser ◽  
Stanislawa Sabalinska ◽  
Jerzy Kawiak ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Vessel ◽  
Hollow Fiber ◽  
Membrane Bioreactor ◽  
Hollow Fiber Membrane ◽  
In Vitro Studies ◽  
Fiber Membrane ◽  
Human Endothelial Cells ◽  
Hollow Fiber Membrane Bioreactor

Hydrodynamically stable adhesion of endothelial cells onto a polypropylene hollow fiber membrane by modification with adhesive protein

2003 ◽  
Vol 6 (3) ◽  
pp. 222-226 ◽  
Author(s):  
Mutsumi Takagi ◽  
Kouji Shiwaku ◽  
Takeomi Inoue ◽  
Yukitoshi Shirakawa ◽  
Yoshiki Sawa ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Fiber Membrane ◽  
Adhesive Protein

Simulation of Oxygen Permeability of Dual-phase Hollow Fiber Membrane

2012 ◽  
Vol 27 (9) ◽  
pp. 951-955
Author(s):  
Chun-Li YANG ◽  
Qi-Ming XU ◽  
Ming GONG ◽  
Wei LIU
Keyword(s):  
Hollow Fiber ◽  
Oxygen Permeability ◽  
Hollow Fiber Membrane ◽  
Dual Phase ◽  
Fiber Membrane

scholarly journals Kinetic Analysis of Lidocaine Elimination by Pig Liver Cells Cultured in 3D Multi-Compartment Hollow Fiber Membrane Network Perfusion Bioreactors

2021 ◽  
Vol 8 (8) ◽  
pp. 104
Author(s):  
Gerardo Catapano ◽  
Juliane K. Unger ◽  
Elisabetta M. Zanetti ◽  
Gionata Fragomeni ◽  
Jörg C. Gerlach
Keyword(s):  
Kinetic Analysis ◽  
Drug Screening ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Liver Cells ◽  
Fiber Membrane ◽  
Bioreactor Design ◽  
Drug Adsorption ◽  
And Performance ◽  
Cells Cultured

Liver cells cultured in 3D bioreactors is an interesting option for temporary extracorporeal liver support in the treatment of acute liver failure and for animal models for preclinical drug screening. Bioreactor capacity to eliminate drugs is generally used for assessing cell metabolic competence in different bioreactors or to scale-up bioreactor design and performance for clinical or preclinical applications. However, drug adsorption and physical transport often disguise the intrinsic drug biotransformation kinetics and cell metabolic state. In this study, we characterized the intrinsic kinetics of lidocaine elimination and adsorption by porcine liver cells cultured in 3D four-compartment hollow fiber membrane network perfusion bioreactors. Models of lidocaine transport and biotransformation were used to extract intrinsic kinetic information from response to lidocaine bolus of bioreactor versus adhesion cultures. Different from 2D adhesion cultures, cells in the bioreactors are organized in liver-like aggregates. Adsorption on bioreactor constituents significantly affected lidocaine elimination and was effectively accounted for in kinetic analysis. Lidocaine elimination and cellular monoethylglicinexylidide biotransformation featured first-order kinetics with near-to-in vivo cell-specific capacity that was retained for times suitable for clinical assist and drug screening. Different from 2D cultures, cells in the 3D bioreactors challenged with lidocaine were exposed to close-to-physiological lidocaine and monoethylglicinexylidide concentration profiles. Kinetic analysis suggests bioreactor technology feasibility for preclinical drug screening and patient assist and that drug adsorption should be accounted for to assess cell state in different cultures and when laboratory bioreactor design and performance is scaled-up to clinical use or toxicological drug screening.

scholarly journals Development of mass and heat transfer coupled model of hollow fiber membrane for salt recovery from brine via osmotic membrane distillation

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Sher Ahmad ◽  
Gabriela Vollet Marson ◽  
Waheed Ur Rehman ◽  
Mohammad Younas ◽  
Sarah Farrukh ◽  
...  
Keyword(s):  
Mass Transfer ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Heat And Mass Transfer ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Membrane Distillation ◽  
Fiber Membrane ◽  
Salt Recovery ◽  
Osmotic Solution

Abstract Background In this research work, a coupled heat and mass transfer model was developed for salt recovery from concentrated brine water through an osmotic membrane distillation (OMD) process in a hollow fiber membrane contactor (HFMC).The model was built based on the resistance-in-series concept for water transport across the hydrophobic membrane. The model was adopted to incorporate the effects of polarization layers such as temperature and concentration polarization, as well as viscosity changes during concentration. Results The modeling equations were numerically simulated in MATLAB® and were successfully validated with experimental data from literature with a deviation within the range of 1–5%. The model was then applied to study the effects of key process parameters like feed concentrations, osmotic solution concentration, feed, and osmotic solution flow rates and feed temperature on the overall heat and mass transfer coefficient as well as on water transport flux to improve the process efficiency. The mass balance modeling was applied to calculate the membrane area based on the simulated mass transfer coefficient. Finally, a scale-up for the MD process for salt recovery on an industrial scale was proposed. Conclusions This study highlights the effect of key parameters for salt recovery from wastewater using the membrane distillation process. Further, the applicability of the OMD process for salt recovery on large scale was investigated. Sensitivity analysis was performed to identify the key parameters. From the results of this study, it is concluded that the OMD process can be promising in salt recovery from wastewater.

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