Possible origin of action potential and birefringence change in nerve axon

1971 ◽  
Vol 33 (4) ◽  
pp. 521-537 ◽  
Author(s):  
Ling Y. Wei
Keyword(s):  
Action Potential ◽  
Nerve Axon

Action of Tetraethylammonium Chloride on Neuromuscular Transmission in Frogs

1958 ◽  
Vol 193 (1) ◽  
pp. 213-218 ◽  
Author(s):  
Kyozo Koketsu
Keyword(s):  
Action Potential ◽  
Neuromuscular Transmission ◽  
Direct Action ◽  
Motor Nerve ◽  
Muscle Fibers ◽  
Nerve Fibers ◽  
Tetraethylammonium Chloride ◽  
Nerve Axon ◽  
Mechanical Responses ◽  
End Plate

The action of tetraethylammonium chloride (TEA-Cl) on the neuromuscular transmission in frogs of 0.2–3 mm concentration was analyzed by recording a) the mechanical responses; b) direct action on the muscle fibers; c) end-plate potential (e.p.p.); d) direct action on the end-plate membrane; e) sensitivity of end-plate membrane to the applied ACh; f) the action potential of terminal endings of motor nerve fibers; g) direct action of nerve axon. TEA-Cl in these concentrations augments the e.p.p., and this augmentation increases with increasing concentrations. A relatively higher concentration (1–3 mm) depresses the e.p.p. after an initial augmentation. The sensitivity of the end-plate membrane to ACh is depressed by 0.2–3 mm. TEA-Cl in these concentrations acts on the terminal endings of motor nerve fibers and prolongs the negative after-potential of terminal endings. It is suggested that TEA-Cl increases the release of ACh by acting on the terminal endings, thus causing the augmentation of e.p.p.'s. The action of TEA-Cl at a given concentration will be determined by separate actions both on the end-plate membrane and the terminal ending of motor nerve fibers.

How to sample the entire length of a single muscle fiber quick-frozen after electrical point stimulation for high resolution EM

1992 ◽  
Vol 50 (1) ◽  
pp. 776-777
Author(s):  
Joachim R. Sommer ◽  
Teresa High ◽  
Betty Scherer ◽  
Isaiah Taylor ◽  
Rashid Nassar
Keyword(s):  
Skeletal Muscle ◽  
High Resolution ◽  
Action Potential ◽  
Muscle Fiber ◽  
Freeze Fracture ◽  
Freeze Substitution ◽  
Electrical Field Stimulation ◽  
Skeletal Muscle Fiber ◽  
Freeze Dried ◽  
Quick Freezing

We have developed a model that allows the quick-freezing at known time intervals following electrical field stimulation of a single, intact frog skeletal muscle fiber isolated by sharp dissection. The preparation is used for studying high resolution morphology by freeze-substitution and freeze-fracture and for electron probe x-ray microanlysis of sudden calcium displacement from intracellular stores in freeze-dried cryosections, all in the same fiber. We now show the feasibility and instrumentation of new methodology for stimulating a single, intact skeletal muscle fiber at a point resulting in the propagation of an action potential, followed by quick-freezing with sub-millisecond temporal resolution after electrical stimulation, followed by multiple sampling of the frozen muscle fiber for freeze-substitution, freeze-fracture (not shown) and cryosectionmg. This model, at once serving as its own control and obviating consideration of variances between different fibers, frogs etc., is useful to investigate structural and topochemical alterations occurring in the wake of an action potential.

Preceding Stimulus Frequency-Dependent Potentiation of the Postrest Shortening of the Action Potential Duration in Rabbits.

2000 ◽  
Vol 41 (4) ◽  
pp. 481-492
Author(s):  
Naohiko Takahashi ◽  
Morio Ito ◽  
Shuji Ishida ◽  
Takao Fujino ◽  
Mikiko Nakagawa ◽  
...  
Keyword(s):  
Action Potential ◽  
Action Potential Duration ◽  
Stimulus Frequency ◽  
Frequency Dependent ◽  
Preceding Stimulus
Sign in / Sign up

Export Citation Format

Share Document