Alterations in key carbohydrate-metabolizing enzyme activities in rat livers following bile duct ligation and its release

1988 ◽  
Vol 18 (1) ◽  
pp. 68-76 ◽  
Author(s):  
Kenichi Hirata ◽  
Hisashi Mimura ◽  
Kunzo Orita
Keyword(s):  
Bile Duct ◽  
Enzyme Activities ◽  
Bile Duct Ligation ◽  
Duct Ligation ◽  
Metabolizing Enzyme ◽  
Rat Livers

Effect of Bile-Duct Ligation on Organelle Marker Enzymes in the Liver and Serum of Rats

1975 ◽  
Vol 48 (4) ◽  
pp. 307-313
Author(s):  
T. J. Peters ◽  
G. Neale ◽  
J. R. Heath
Keyword(s):  
Endoplasmic Reticulum ◽  
Plasma Membrane ◽  
Bile Duct ◽  
Enzyme Activities ◽  
Liver Tissue ◽  
Bile Duct Ligation ◽  
Monoamine Oxidase A ◽  
Mitochondrial Enzyme ◽  
Marker Enzymes ◽  
Duct Ligation

1. Marker enzymes for the principal subcellular organelles of rat liver were asayed in the liver of rats 1 day and 8 days after bile-duct ligation or after laparotomy as a control procedure. 2. The microsomal enzymes in liver tissue showed complex changes. Benz[α]pyrene hydroxylase activity, predominantly found in the smooth endoplasmic reticulum, was decreased. Glucose 6-phosphatase activity and ribonucleic acid, which are localized predominantly in the rough endoplasmic reticulum, were increased. 3. The plasma membrane enzyme, alkaline phosphatase, increased in activity after bile-duct ligation. 4. No changes in mitochondrial enzyme activities were noted after 1 day but there was a 50% reduction 8 days after ligation. Lysosomal enzyme activities did not change in the liver tissue. 5. Liver catalase and d-amino acid oxidase activities showed a slight increase at 1 day post-ligation but a significant fall by 8 days. 6. Lactate dehydrogenase, a cytosol enzyme, showed a decrease in activity after 1 day but an increase in tissue activities 8 days after ligation. 7. Serum activities of mitochondrial, plasma membrane, microsomal, lysosomal and cytosol marker enzymes tended to increase post-ligation, particularly at 8 days. 8. Monoamine oxidase, a predominantly mitochondrial enzyme, was greatly elevated in the serum after 1 day but had returned to normal activities by 8 days.

Bid-mediated apoptosis does not contribute to cholestatic liver injury following bile duct ligation

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
P Nalapareddy ◽  
S Schüngel ◽  
MP Manns ◽  
H Jaeschke ◽  
A Vogel
Keyword(s):  
Bile Duct ◽  
Liver Injury ◽  
Bile Duct Ligation ◽  
Duct Ligation ◽  
Cholestatic Liver Injury

HGF/c-Met and IL-6/gp130 cooperatively regulate liver homeostasis and antibacterial signalling after bile-duct-ligation

2010 ◽  
Vol 48 (01) ◽  
Author(s):  
A Giebeler ◽  
S Erschfeld ◽  
C Birchmeier ◽  
C Trautwein ◽  
KL Streetz
Keyword(s):  
Bile Duct ◽  
Bile Duct Ligation ◽  
Duct Ligation

Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis

2012 ◽  
Vol 32 (9) ◽  
pp. 1342-1353 ◽  
Author(s):  
Erawan Borkham-Kamphorst ◽  
Sebastian Huss ◽  
Eddy Leur ◽  
Ute Haas ◽  
Ralf Weiskirchen
Keyword(s):  
Bile Duct ◽  
Gene Transfer ◽  
Liver Fibrosis ◽  
Bile Duct Ligation ◽  
Hepatocyte Apoptosis ◽  
Duct Ligation

Hepatic peroxiredoxin expression is increased in rats with chronic bile duct ligation

2000 ◽  
Vol 118 (4) ◽  
pp. A924
Author(s):  
Steven Douglas Colquhoun ◽  
Caroline A. Connelly ◽  
Lawrence Chen ◽  
Delai Zhao ◽  
Hungyi Shau
Keyword(s):  
Bile Duct ◽  
Bile Duct Ligation ◽  
Duct Ligation
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