A study on the correlation between estrogen receptor, progesterone receptor and tamoxifen binding sites in human breast cancer tissues

1987 ◽  
Vol 17 (6) ◽  
pp. 487-492
Author(s):  
Yoko Imanaka ◽  
Seikichi Tsuboi ◽  
Norio Kohno ◽  
Yoichi Saitoh
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Binding Sites ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Cancer Tissues

Expression of estrogen receptor beta isoforms in human breast cancer tissues and cell lines

2002 ◽  
Vol 71 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Dan Tong ◽  
Eva Schuster ◽  
Michael Seifert ◽  
Klaus Czerwenka ◽  
Sepp Leodolter ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cell Lines ◽  
Human Breast Cancer ◽  
Estrogen Receptor Beta ◽  
Human Breast ◽  
Cancer Tissues ◽  
Receptor Beta

Estrogen receptor α and β expression in human breast cancer tissues analysed by RT-PCR

1998 ◽  
Vol 34 ◽  
pp. S81-S82
Author(s):  
S. Kobavashi ◽  
H. Iwase ◽  
Y. Omoto ◽  
Y. Hara ◽  
Y. Ando
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Human Breast Cancer ◽  
Estrogen Receptor Α ◽  
Human Breast ◽  
Rt Pcr ◽  
Cancer Tissues

scholarly journals Novel Stromal Biomarkers in Human Breast Cancer Tissues Provide Evidence for the More Malignant Phenotype of Estrogen Receptor-Negative Tumors

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Zahraa I. Khamis ◽  
Ziad J. Sahab ◽  
Stephen W. Byers ◽  
Qing-Xiang Amy Sang
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Human Breast Cancer ◽  
Genetic Alterations ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Human Breast Carcinomas ◽  
Er Positive ◽  
Cancer Tissues

Research efforts were focused on genetic alterations in epithelial cancer cells. Epithelial-stromal interactions play a crucial role in cancer initiation, progression, invasion, angiogenesis, and metastasis; however, the active role of stroma in human breast tumorigenesis in relation to estrogen receptor (ER) status of epithelial cells has not been explored. Using proteomics and biochemical approaches, we identified two stromal proteins in ER-positive and ER-negative human breast cancer tissues that may affect malignant transformation in breast cancer. Two putative biomarkers, T-cell receptor alpha (TCR-α) and zinc finger and BRCA1-interacting protein with a KRAB domain (ZBRK1), were detected in leukocytes of ER-positive and endothelial cells of ER-negative tissues, respectively. Our data suggest an immunosuppressive role of leukocytes in invasive breast tumors, propose a multifunctional nature of ZBRK1 in estrogen receptor regulation and angiogenesis, and demonstrate the aggressiveness of ER-negative human breast carcinomas. This research project may identify new stromal drug targets for the treatment of breast cancer patients.

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