Natural killer activity of peripheral blood lymphocytes and its relation to histopathological factors of lung cancer

1987 ◽  
Vol 17 (4) ◽  
pp. 236-242 ◽  
Author(s):  
Akio Terazawa ◽  
Noriaki Tanaka ◽  
Noritomo Senou ◽  
Fumiyuki Inoue ◽  
Hiroo Matsuura ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Natural Killer ◽  
Peripheral Blood ◽  
Natural Killer Activity ◽  
Peripheral Blood Lymphocytes ◽  
Killer Activity ◽  
Blood Lymphocytes

scholarly journals Autologous Enhancement by Interferon of Natural Killer Activity of Human Peripheral Blood Lymphocytes

1994 ◽  
Vol 3 (5) ◽  
pp. 341-346
Author(s):  
S. B. Cheknev ◽  
Y. G. Ashmanova ◽  
A. D. Pritsker ◽  
O. L. Latysheva ◽  
F. I. Yershov ◽  
...  
Keyword(s):  
Natural Killer ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Nk Activity ◽  
Killer Activity ◽  
Blood Lymphocytes ◽  
Healthy Donors ◽  
Ifn Γ

Thein vitroaction of interferon (IFN)-α and IFN-γ from six healthy donors and ten patients with multiple sclerosis (MS) on natural killer (INK) activity of peripheral blood lymphocytes (PBL) was studied in an autologous system. The NK activity of PBL was detected by a cytotoxic test using3H-uridine human erythromyeloblast K562 cells. Autologous IFN-α and IFN-γ did not augment NK activity of PBL from healthy donorsin vitro, whereas in samples from MS patients the IFNs strongly stimulated NK cell cytotoxic function. This stimulation suggests the existence of an inhibitor of regulatory IFN action, that is produced in healthy donors simultaneously with IFN in response to IFN induction, but which is lacking in commercial IFN preparations. The factor-containing supernatants from healthy donors reduced the stimulatory action of autologous IFNs in patients with MS almost until complete blockade. Because this inhibitor was absent in patients with MS, deficiency of an inhibitor of IFN regulatory action in MS could open the way to treatment of this compartment of the immune system.

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