Chemiluminescence determination of tiopronin and its metabolite 2-mercaptopropionic acid in human urine by HPLC coupled with flow injection

1997 ◽  
Vol 44 (1-2) ◽  
pp. 31-36 ◽  
Author(s):  
Yining Zhao ◽  
W. R. G. Baeyens ◽  
X. R. Zhang ◽  
A. C. Calokerinos ◽  
K. Nakashima ◽  
...  
Keyword(s):  
Flow Injection ◽  
Human Urine ◽  
Mercaptopropionic Acid

scholarly journals Determination of Creatinine in Human Urine with Flow Injection Tandem Mass Spectrometry

2012 ◽  
Vol 61 (4) ◽  
pp. 314-321 ◽  
Author(s):  
Mareile Niesser ◽  
Berthold Koletzko ◽  
Wolfgang Peissner
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Flow Injection ◽  
Human Urine ◽  
Tandem Mass

Chemiluminescent Determination of Tiopronin and its Metabolite, 2-Mercaptopropionic Acid, in Urine by HPLC Coupled with a Flow Injection Set-up

1997 ◽  
Vol 11 (2) ◽  
pp. 115-116 ◽  
Author(s):  
Yining Zhao ◽  
Willy R. G. Baeyens ◽  
Xinrong Zhang ◽  
Kenichiro Nakashima ◽  
A. C. Calokerinos ◽  
...  
Keyword(s):  
Flow Injection ◽  
Mercaptopropionic Acid ◽  
Set Up

Determination of risperidone at picogram level in human urine by luminol—H2O2 chemiluminescence

2006 ◽  
Vol 60 (4) ◽  
Author(s):  
X. Xie ◽  
X. Shao ◽  
Z. Song
Keyword(s):  
Flow Injection ◽  
Human Urine ◽  
High Sensitivity ◽  
Chemiluminescence Method ◽  
Synergistic Enhancement ◽  
Relative Standard ◽  
Sensitive Determination ◽  
Flow Injection Chemiluminescence ◽  
Simple Flow

AbstractA simple flow-injection chemiluminescence method with synergistic enhancement has been investigated for the rapid and sensitive determination of antipsychotic risperidone. The synergistic action was significant in the chemiluminescence system of luminol—hydrogen peroxide with risperidone as an enhancer. The increased chemiluminescence intensity was correlated with risperidone concentration within the range from 10 pg mL−1 to 1.0 ng mL−1 with relative standard deviations lower than 5.0 % and the detection limit of 4 pg mL−1. At a flow rate of 2.0 mL min−1, the flow-injection chemiluminescence method exhibited both a high sensitivity and excellent selectivity giving a throughput of 120 times per hour. The proposed method was successfully applied to determine the risperidone content in human urine without any pretreatment. It was found that the excretive amounts of risperidone reached their maximum after taking 2.0 mg of risperidone for 1 h, with a total excretive ratio of 17.37 % in 8.5 h.

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