Uracil in Oris of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral reactivation and replication?

Chromosoma ◽  
1992 ◽  
Vol 102 (S1) ◽  
pp. S67-S71 ◽  
Author(s):  
Federico Focher ◽  
Annalisa Verri ◽  
Simona Verzeletti ◽  
Paolo Mazzarello ◽  
Silvio Spadari
Keyword(s):  
Herpes Simplex ◽  
Binding Protein ◽  
Viral Reactivation ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Specific Recognition ◽  
Origin Binding Protein

Enzymes of Human Herpesviruses

1992 ◽  
Vol 57 (8) ◽  
pp. 1577-1612 ◽  
Author(s):  
Pavel Kramata ◽  
Ivan Votruba
Keyword(s):  
Binding Protein ◽  
Human Herpesvirus ◽  
Dna Helicase ◽  
Point Of View ◽  
Uracil Dna Glycosylase ◽  
Replication Complex ◽  
Viral Genomes ◽  
Origin Binding Protein ◽  
Antiviral Chemotherapy ◽  
Human Herpesviruses

The properties of human herpesvirus-encoded enzymes are reviewed and the importance of sequence analysis of viral genomes as well as the experiments on characteristics of enzymes isolated from infected cell cultures are emphasized. The following enzymes are described in detail: DNA replication complex consisting of DNA polymerase, DNA helicase-primase, single-stranded DNA binding protein and origin binding protein, further thymidine kinase, ribonucleotide reductase, deoxyuridine triphosphatase as well as uracil-DNA-glycosylase, deoxyribonuclease and protein kinase. The importance of these enzymes from the point of view of antiviral chemotherapy is discussed.

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