Effect of hypoxia on morphological and functional parameters of astrocytes in a confluent culture

N. I. Mezen; Z. B. Kvacheva; A. S. Fedulov; F. V. Oleshkevich; O. I. Shadyro; V. A. Timoshchuk

doi:10.1007/bf02447674

Response to DDAVP in children with von Willebrand disease type 2

Hämostaseologie ◽

10.1055/s-0037-1617014 ◽

2009 ◽

Vol 29 (02) ◽

pp. 143-148 ◽

Cited By ~ 3

Author(s):

U. Budde ◽

K. Beutel ◽

W.-A. Hassenpflug ◽

H. Hauch ◽

T. Obser ◽

...

Keyword(s):

Disease Type ◽

Von Willebrand Disease ◽

Molecular Defect ◽

Variable Response ◽

Functional Parameters ◽

Functional Defect ◽

Biologic Response ◽

High Level ◽

Von Willebrand

SummaryWe have prospectively evaluated the biologic response to desmopressin (DDAVP) in 28 children with type 2 von Willebrand disease (VWD) in correlation with the phenotype and the molecular defect of VWF. The diagnosis of VWD type 2 was mainly based on VWF functional parameters and/or an aberrant VWF multimer pattern. Seventeen different mutations were identified (6 of them novel). No response with respect to the functional parameters VWF:RCo and/or VWF:CB was seen in patients with severe abnormality of the VWF multimer pattern. One patient with VWD type 2A phenotype IIC Miami did not respond with respect to VWF:CB, but showed a good response of VWF:Ag and FVIII:C as expected. Interestingly he showed a persistently high level of VWF:Ag and FVIII:C up to 4 hours after DDAVP infusion. Patients with minor alterations of multimer structure and particular mutations responded well to DDAVP, whereas patients with normal multimer structure but a defect in platelet dependent functional parameters did not respond with VWF:RCo. Conclusion: Children with VWD type 2 show a variable response to desmopressin depending on the mutation that correlates with the functional defect and the presence or absence as well as the half-life of large VWF multimers. Our data emphasize the usefulness of DDAVP testing even in patients with VWD type 2, possibly with the exception of VWD type 2B.

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IMPORTANT FUNCTIONAL PARAMETERS OF SPERMATOZOA: A REVIEW

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE ◽

10.32395/ijprs.v7.i4.00007 ◽

2018 ◽

Vol 7 (4) ◽

pp. 98-111

Author(s):

KUMAR AMIT ◽

GANGULY SUBHA ◽

PAGRUT NILESHKUMAR

Keyword(s):

Functional Parameters

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RELATION OF THE MARKERS OF MYOCARDIAL DYSFUNCTION AND SYSTEMIC INFLAMMATION WITH STRUCTURAL AND FUNCTIONAL PARAMETERS OF THE LUNGS IN MYOCARDIAL INFARCTION PATIENTS

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2018-2-24-28 ◽

2018 ◽

Vol 17 (2) ◽

pp. 24-28

Author(s):

O. M. Polikutina ◽

Y. S. Slepynina ◽

E. D. Bazdyrev ◽

V. N. Karetnikova ◽

O. L. Barbarach

Keyword(s):

Myocardial Infarction ◽

Systemic Inflammation ◽

Myocardial Dysfunction ◽

Control Group ◽

Chronic Obstructive ◽

Lung Pathology ◽

Functional Changes ◽

Functional Parameters ◽

Lung Capacity ◽

Copd Patients

Aim. To evaluate the structural and functional changes in the lungs of ST elevation myocardial infarction (STEMI) patients with absence or presence of chronic obstructive lung disease (COPD), and the relation with myocardial dysfunction and systemic inflammation.Material and methods. Totally, 189 STEMI patients included: group 1 — STEMI with COPD of moderate and mild grade, 2 — STEMI with no lung pathology. Groups were comparable by clinical and anamnestic parameters. Assessment of lung function and blood collection were done at 1012 day of STEMI. For comparison of the parameters representing structural and functional changes in the lungs and comparison of Creactive protein (CRP), Nterminal probrain natriuretic peptide (NTproBNP) concentration, a control group was formed with no pulmonary pathology, comparable by age and sex with the STEMI patients.Results. In COPD patients, higher values revealed of the parameters representing the part of residual volumes in pulmonary structure. Higher residual volume (RV) was found also in STEMI and no COPD comparing to controls, however the relation RV/TLC (total lung capacity) was not higher than normal range. In both groups there were lower values of diffusion lung capacity (DLCO) comparing to controls. The lowest DLCO found in COPD patients. Concentration of NTproBNP (H=41,6; p<0,001) and CRP (H=38,6; p<0,001) in COPD was significantly higher in STEMI with no COPD patients than in controls. The negative correlations found for NTproBNP and CRP with forced expiratory volume 1 sec, FEV/FVC1, DLCO, and positive — with the values of thoracic volume, RV/TLC.Conclusion. In STEMI patients the increase revealed of residual lung volumes. Mostly the level of residual volumes is high in STEMI and COPD patients. There are associations of NTproBNP and CRP with structural and functional parameters of the lungs regardless of COPD.

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