Significance of the binding ability of hemopoietic microenvironment cells for restoration of individual hemopoietic stem precursors suppressed by cytostatic drugs

1996 ◽  
Vol 122 (5) ◽  
pp. 1074-1077
Author(s):  
V. V. Zhdanov ◽  
A. M. Dygai ◽  
E. V. Kirienkova ◽  
M. Yu. Minakova ◽  
E. D. Gol'dberg
Keyword(s):  
Cytostatic Drugs ◽  
Binding Ability ◽  
Hemopoietic Microenvironment

Protective influence of coded amino acids on the development of liver tissue culture in the presence of cytostatic

2020 ◽  
pp. 48-53
Author(s):  
N. I. Chalisova ◽  
V. K. Kozlov ◽  
A. B. Mulik ◽  
E. P. Zatsepin ◽  
T. A. Kostrova
Keyword(s):  
Amino Acids ◽  
Tissue Culture ◽  
Side Effects ◽  
Liver Tissue ◽  
Organotypic Culture ◽  
Growth Zone ◽  
Inhibitory Effect ◽  
Cytostatic Drugs ◽  
Urgent Problem ◽  
Combined Exposure

An urgent problem is the search for substances that can provide a protective effect in cases of DNA synthesis and repair disorders that arise as a result of side effects of cytostatic drugs used in the treatment of cancer. The aim of this work was to study the effect of 20 encoded amino acids in the presence of Cyclophosphane on the development of organotypic culture of rat liver tissue. The results obtained indicate that Cyclophosphane; which simulates the action of such cytostatic substances; inhibits cell proliferation in the liver tissue. It was also found that the encoded amino acids: asparagine; arginine; and glutamic acid; eliminate the inhibitory effect of Cyclophosphane in liver tissue culture. The growth zone of explants after combined exposure to Cyclophosphane (whose isolated action suppressed the growth zone) and these amino acids increased significantly and reached control values. Thus; the experimental data create the basis for the development of methods for the therapeutic use of the three studied amino acids for the removal of side effects in the treatment with cytostatic drugs.

ABATEMENT OF ANTICANCER DRUGS VIA ELECTROCHEMICAL OXIDATION PROCESS: A REVIEW

2020 ◽  
pp. 1-4
Author(s):  
CHARULATA SIVODIA ◽  
ALOK SINHA
Keyword(s):  
Anticancer Drugs ◽  
Cell Function ◽  
Electrochemical Techniques ◽  
Aquatic Organisms ◽  
Pharmaceutical Drugs ◽  
Cytostatic Drugs ◽  
Cancerous Cell ◽  
Pharmaceutical Removal ◽  
Mutagenic Effects ◽  
Made In

The advancement made in biomedical industry upsurges the consumption rate of pharmaceutical drugs. The lack of proper monitoring and regulation methods leads to the unregulated discharge of pharmaceuticals in wastewater, where it can affect the aquatic organisms. Anticancer drugs are also known as cytostatic drugs mainly used for the treatment of cancer by disrupting the cell function and prevent multiplication of cancerous cell. Therefore, anticancer drugs are suspected to pose potential risk on environment by influencing mutagenic effects on the cells of aquatic organisms. An extensive research has been already made in the field of pharmaceutical removal, however their application on the removal of anticancer drugs is limited. This review paper elucidates about different electrochemical techniques for the mitigation of cytostatic drugs.

Prostate Cancer, miRNAs, Metallothioneins and Resistance to Cytostatic Drugs

2013 ◽  
Vol 20 (4) ◽  
pp. 534-544 ◽  
Author(s):  
V. Pekarik ◽  
J. Gumulec ◽  
M. Masarik ◽  
R. Kizek ◽  
V. Adam
Keyword(s):  
Prostate Cancer ◽  
Cytostatic Drugs

Treponema, Iron and Neurodegeneration

2018 ◽  
Vol 15 (8) ◽  
pp. 716-722 ◽  
Author(s):  
A. Jolivet-Gougeon ◽  
M. Bonnaure-Mallet
Keyword(s):  
Iron Metabolism ◽  
Plasma Proteins ◽  
Iron Homeostasis ◽  
Neurological Diseases ◽  
Host Cells ◽  
Loss Of Function ◽  
Binding Ability ◽  
Iron Binding Proteins ◽  
Oxidative Species ◽  
Iron Reductase

Spirochetes are suspected to be linked to the genesis of neurological diseases, including neurosyphillis or neurodegeneration (ND). Impaired iron homeostasis has been implicated in loss of function in several enzymes requiring iron as a cofactor, formation of toxic oxidative species, inflammation and elevated production of beta-amyloid proteins. This review proposes to discuss the link that may exist between the involvement of Treponema spp. in the genesis or worsening of ND, and iron dyshomeostasis. Proteins secreted by Treponema can act directly on iron metabolism, with hemin binding ability (HbpA and HbpB) and iron reductase able to reduce the central ferric iron of hemin, iron-containing proteins (rubredoxin, neelaredoxin, desulfoferrodoxin metalloproteins, bacterioferritins etc). Treponema can also interact with cellular compounds, especially plasma proteins involved in iron metabolism, contributing to the virulence of the syphilis spirochetes (e.g. treponemal motility and survival). Fibronectin, transferrin and lactoferrin were also shown to be receptors for treponemal adherence to host cells and extracellular matrix. Association between Treponema and iron binding proteins results in iron accumulation and sequestration by Treponema from host macromolecules during systemic and mucosal infections.

scholarly journals Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.

1994 ◽  
Vol 14 (11) ◽  
pp. 7557-7568 ◽  
Author(s):  
J Zuo ◽  
R Baler ◽  
G Dahl ◽  
R Voellmy
Keyword(s):  
Transcription Factor ◽  
Heat Stress ◽  
Heat Shock ◽  
Dna Binding ◽  
Hydrophobic Interactions ◽  
Coiled Coil ◽  
Heat Shock Transcription Factor ◽  
Single Amino Acid ◽  
Binding Ability ◽  
Heat Shock Element

Heat stress regulation of human heat shock genes is mediated by human heat shock transcription factor hHSF1, which contains three 4-3 hydrophobic repeats (LZ1 to LZ3). In unstressed human cells (37 degrees C), hHSF1 appears to be in an inactive, monomeric state that may be maintained through intramolecular interactions stabilized by transient interaction with hsp70. Heat stress (39 to 42 degrees C) disrupts these interactions, and hHSF1 homotrimerizes and acquires heat shock element DNA-binding ability. hHSF1 expressed in Xenopus oocytes also assumes a monomeric, non-DNA-binding state and is converted to a trimeric, DNA-binding form upon exposure of the oocytes to heat shock (35 to 37 degrees C in this organism). Because endogenous HSF DNA-binding activity is low and anti-hHSF1 antibody does not recognize Xenopus HSF, we employed this system for mapping regions in hHSF1 that are required for the maintenance of the monomeric state. The results of mutagenesis analyses strongly suggest that the inactive hHSF1 monomer is stabilized by hydrophobic interactions involving all three leucine zippers which may form a triple-stranded coiled coil. Trimerization may enable the DNA-binding function of hHSF1 by facilitating cooperative binding of monomeric DNA-binding domains to the heat shock element motif. This view is supported by observations that several different LexA DNA-binding domain-hHSF1 chimeras bind to a LexA-binding site in a heat-regulated fashion, that single amino acid replacements disrupting the integrity of hydrophobic repeats render these chimeras constitutively trimeric and DNA binding, and that LexA itself binds stably to DNA only as a dimer but not as a monomer in our assays.

scholarly journals Disruption of key NADH-binding pocket residues of the Mycobacterium tuberculosis InhA affects DD-CoA binding ability

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Daniel J. Shaw ◽  
Kirsty Robb ◽  
Beatrice V. Vetter ◽  
Madeline Tong ◽  
Virginie Molle ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Binding Pocket ◽  
Binding Ability

Determination of cytostatic drugs in Besòs River (NE Spain) and comparison with predicted environmental concentrations

2017 ◽  
Vol 24 (7) ◽  
pp. 6492-6503 ◽  
Author(s):  
Helena Franquet-Griell ◽  
Deborah Cornadó ◽  
Josep Caixach ◽  
Francesc Ventura ◽  
Silvia Lacorte
Keyword(s):  
Cytostatic Drugs ◽  
Environmental Concentrations ◽  
Predicted Environmental Concentrations ◽  
Ne Spain
Sign in / Sign up

Export Citation Format

Share Document