Selective activation of muscles using peripheral nerve electrodes

1985 ◽  
Vol 23 (3) ◽  
pp. 249-253 ◽  
Author(s):  
D. R. McNeal ◽  
B. R. Bowman
Keyword(s):  
Peripheral Nerve ◽  
Selective Activation ◽  
Nerve Electrodes ◽  
Peripheral Nerve Electrodes

scholarly journals On the use of Parylene C polymer as substrate for peripheral nerve electrodes

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Natàlia de la Oliva ◽  
Matthias Mueller ◽  
Thomas Stieglitz ◽  
Xavier Navarro ◽  
Jaume del Valle
Keyword(s):  
Peripheral Nerve ◽  
Parylene C ◽  
Nerve Electrodes ◽  
Peripheral Nerve Electrodes

Package Architecture and Component Design for an Implantable Peripheral Nerve Stimulation and Recording System for Advanced Prosthetics

2016 ◽  
Vol 2016 (1) ◽  
pp. 000144-000150
Author(s):  
Caroline K. Bjune ◽  
John R. Lachapelle ◽  
Andrew Czarnecki ◽  
Alexander L. Kindle ◽  
John R. Burns ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Stimulation ◽  
Sensory Feedback ◽  
Hand Movement ◽  
Phantom Limb Pain ◽  
Sensory Stimulation ◽  
Peripheral Nerve Stimulation ◽  
Phantom Limb ◽  
Component Design ◽  
Nerve Electrodes

Abstract One of the limitation of current prosthetics is the ability to provide sensory feedback to the human user. Due to this constraint, approximately 60–80 percent of amputees experience a phenomenon known as phantom limb pain, an ongoing painful sensations that to the individual, seems to be coming from the part of the limb that is no longer there. The lack of sensory feedback also limits the intuitive control of the user's hand movement, i.e. sense of grip or position. To address these limitations, we created am implantable system that could provide peripheral nerve stimulation, recording and motor control. The architecture of our Sensory-Stimulation Lead (SSL) system consist of multiple satellites connected to Draper's custom designed nerve electrodes. In this phase of the design, the implanted system is connected to a controller via percutaneous connections. The active electronics of the satellite is enclosed in a hermetic package approximately 14mm in diameter and less than 5mm thick. A custom ceramic feedthrough substrate provides the electrical connections of the internal electronics board to both the nerve electrodes and percutaneous leads. In this paper, we will describe the various packaging components of the system and the design, fabrication, and assembly considerations that drove our technology choices.

scholarly journals Position-selective activation of peripheral nerve fibers with a cuff electrode

1996 ◽  
Vol 43 (8) ◽  
pp. 851-856 ◽  
Author(s):  
E.V. Goodall ◽  
J.F. de Breij ◽  
J. Holsheimer
Keyword(s):  
Peripheral Nerve ◽  
Nerve Fibers ◽  
Selective Activation ◽  
Cuff Electrode

Facilitated migration of cells from a transected peripheral nerve over collagen fibers: in vivo observations

1989 ◽  
Vol 47 ◽  
pp. 888-889
Author(s):  
Arthur J. Wasserman ◽  
Azam Rizvi ◽  
George Zazanis ◽  
Frederick H. Silver
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Collagen Gel ◽  
Collagen Fibers ◽  
Control Group ◽  
Guide Tube ◽  
Sprague Dawley ◽  
Silicone Tube ◽  
Thin Sections

In cases of peripheral nerve damage the gap between proximal and distal stumps can be closed by suturing the ends together, using a nerve graft, or by nerve tubulization. Suturing allows regeneration but does not prevent formation of painful neuromas which adhere to adjacent tissues. Autografts are not reported to be as good as tubulization and require a second surgical site with additional risks and complications. Tubulization involves implanting a nerve guide tube that will provide a stable environment for axon proliferation while simultaneously preventing formation of fibrous scar tissue. Supplementing tubes with a collagen gel or collagen plus extracellular matrix factors is reported to increase axon proliferation when compared to controls. But there is no information regarding the use of collagen fibers to guide nerve cell migration through a tube. This communication reports ultrastructural observations on rat sciatic nerve regeneration through a silicone nerve stent containing crosslinked collagen fibers.Collagen fibers were prepared as described previously. The fibers were threaded through a silicone tube to form a central plug. One cm segments of sciatic nerve were excised from Sprague Dawley rats. A control group of rats received a silicone tube implant without collagen while an experimental group received the silicone tube containing a collagen fiber plug. At 4 and 6 weeks postoperatively, the implants were removed and fixed in 2.5% glutaraldehyde buffered by 0.1 M cacodylate containing 1.5 mM CaCl2 and balanced by 0.1 M sucrose. The explants were post-fixed in 1% OSO4, block stained in 1% uranyl acetate, dehydrated and embedded in Epon. Axons were counted on montages prepared at a total magnification of 1700x. Montages were viewed through a dissecting microscope. Thin sections were sampled from the proximal, middle and distal regions of regenerating sciatic plugs.

Ubiquinone-BODIPY nanoparticles for tumor redox-responsive fluorescence imaging and photodynamic activity

2021 ◽  
Author(s):  
Byunghee Hwang ◽  
Tae-Il Kim ◽  
Hyunjin Kim ◽  
Sungjin Jeon ◽  
Yongdoo Choi ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Selective Activation ◽  
Turn On ◽  
Intracellular Environment ◽  
Redox Responsive ◽  
Photodynamic Activity

A ubiquinone-BODIPY photosensitizer self-assembles into nanoparticles (PS-Q-NPs) and undergoes selective activation within the highly reductive intracellular environment of tumors, resulting in “turn-on” fluorescence and photosensitizing activities.

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