Examination of the choice of models for computing the extracellular potential of a single fibre in a restricted volume conductor

1991 ◽  
Vol 29 (6) ◽  
pp. 580-584 ◽  
Author(s):  
N. Trayanova ◽  
C. S. Henriquez
Keyword(s):  
Single Fibre ◽  
Volume Conductor ◽  
Extracellular Potential ◽  
Restricted Volume

Extracellular potentials and currents of a single active fiber in a restricted volume conductor

1990 ◽  
Vol 18 (3) ◽  
pp. 219-238 ◽  
Author(s):  
Natalia Trayanova ◽  
Craig S. Henriquez ◽  
Robert Plonsey
Keyword(s):  
Volume Conductor ◽  
Active Fiber ◽  
Restricted Volume ◽  
Extracellular Potentials

The Role of Computer Modeling in Electrocardiography

1990 ◽  
Vol 29 (04) ◽  
pp. 282-288 ◽  
Author(s):  
A. van Oosterom
Keyword(s):  
Electrical Activity ◽  
Computer Modeling ◽  
Body Surface ◽  
Electrical Current ◽  
The Body ◽  
Volume Conductor ◽  
Current Generator ◽  
Cardiac Electrical Activity ◽  
Source Models

AbstractThis paper introduces some levels at which the computer has been incorporated in the research into the basis of electrocardiography. The emphasis lies on the modeling of the heart as an electrical current generator and of the properties of the body as a volume conductor, both playing a major role in the shaping of the electrocardiographic waveforms recorded at the body surface. It is claimed that the Forward-Problem of electrocardiography is no longer a problem. Several source models of cardiac electrical activity are considered, one of which can be directly interpreted in terms of the underlying electrophysiology (the depolarization sequence of the ventricles). The importance of using tailored rather than textbook geometry in inverse procedures is stressed.

Single Cell Based Microelectrode Array Biosensors

2003 ◽  
Vol 773 ◽  
Author(s):  
Mo Yang ◽  
Shalini Prasad ◽  
Xuan Zhang ◽  
Mihrimah Ozkan ◽  
Cengiz S. Ozkan
Keyword(s):  
Electrical Activity ◽  
Single Cell ◽  
Cellular Response ◽  
Microelectrode Array ◽  
Fast Fourier Transformation ◽  
Chemical Agent ◽  
Extracellular Potential ◽  
Membrane Excitability ◽  
Specific Chemical ◽  
Chemical Agents

AbstractExtracellular potential is an important parameter which indicates the electrical activity of live cells. Membrane excitability in osteoblasts plays a key role in modulating the electrical activity in the presence of chemical agents. The complexity of cell signal makes interpretation of the cellular response to a chemical agent very difficult. By analyzing shifts in the signal power spectrum, it is possible to determine a frequency spectrum also known as Signature Pattern Vectors (SPV) specific to a chemical. It is also essential to characterize single cell sensitivity and response time for specific chemical agents for developing detect-to-warn biosensors. We used a 4x4 multiple Pt microelectrode array to spatially position single osteoblast cells, by using a gradient AC field. Fast Fourier Transformation (FFT) and Wavelet Transformation (WT) analyses were used to extract information pertaining to the frequency of firing from the extracellular potential.

An Energy-Based interpretation of Interfacial Adhesion from Single Fibre Composite Fragmentation Testing

1993 ◽  
Vol 2 (5) ◽  
pp. 096369359300200 ◽  
Author(s):  
H.D. Wagner ◽  
S. Ling
Keyword(s):  
Interfacial Adhesion ◽  
Mechanical Characteristics ◽  
Interfacial Shear Strength ◽  
Fibre Composite ◽  
Stress Transfer ◽  
Single Fibre ◽  
Transfer Length ◽  
Fragmentation Test ◽  
Energy Balance Approach ◽  
Fibre Matrix

An energy balance approach is proposed for the single fibre composite (or fragmentation) test, by which the degree of fibre-matrix bonding is quantified by means of the interfacial energy, rather than the interfacial shear strength, as a function of the fibre geometrical and mechanical characteristics, the stress transfer length, and the debonding length. The validity of the approach is discussed using E-glass fibres embedded in epoxy, both in the dry state and in the presence of hot distilled water.

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