Effect of antibodies to red cell superoxide dismutase on its activity in the blood of patients with rheumatoid arthritis

1995 ◽  
Vol 120 (4) ◽  
pp. 1024-1026
Author(s):  
I. P. Gontar' ◽  
L. N. Bobrova ◽  
I. A. Zborovskaya
Keyword(s):  
Rheumatoid Arthritis ◽  
Superoxide Dismutase ◽  
Red Cell

scholarly journals Association between red cell distribution width and response to methotrexate in rheumatoid arthritis

Reumatismo ◽  
2020 ◽  
Vol 72 (1) ◽  
pp. 16-20 ◽  
Author(s):  
M. Bellan ◽  
D. Soddu ◽  
E. Zecca ◽  
A. Croce ◽  
R. Bonometti ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Treatment Response ◽  
Strong Predictor ◽  
Poor Response ◽  
Early Response ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Eular Response ◽  
Distribution Width

Red cell distribution width (RDW) is an unconventional biomarker of inflammation. We aimed to explore its role as a predictor of treatment response in rheumatoid arthritis (RA). Eighty-two RA patients (55 females), median age [interquartile range] 63 years [52-69], were selected by scanning the medical records of a rheumatology clinic, to analyze the associations between baseline RDW, disease activity scores and inflammatory markers, as well as the relationship between RDW changes following methotrexate (MTX) and treatment response. The lower the median baseline RDW, the greater were the chances of a positive EULAR response at three months, 13.5% [13.0-14.4] being among those with good response, vs 14.0% [13.2-14.7] and 14.2% [13.5- 16.0] (p=0.009) among those with moderate and poor response, respectively. MTX treatment was followed by a significant RDW increase (p<0.0001). The increase of RDW was greater among patients with good EULAR response, becoming progressively smaller in cases with moderate and poor response (1.0% [0.4-1.4] vs. 0.7 [0.1-2.0] vs. 0.3 [-0.1-0.8]; p=0.03). RDW is a strong predictor of early response to MTX in RA. RDW significantly increases after MTX initiation in parallel to treatment response, suggesting a role as a marker of MTX effectiveness.

scholarly journals Redox Status in Women with Rheumathoid Arthritis

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Aleksandra Vranic ◽  
Aleksandra Antovic ◽  
Nevena Draginic ◽  
Marijana Andjic ◽  
Marko Ravic ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Cartilage Damage ◽  
Thiobarbituric Acid ◽  
Antioxidant Defense System ◽  
Redox Status ◽  
Female Population

Abstract The aim of this study was to assess oxidative status and to set baseline characteristics for female population with established rheumatoid arthritis. Total of 42 patients with rheumatoid arthritis and 48 age- and sex-matched controls were included in the study. Clinical examination was performed and assessed disease activity. Peripheral blood samples were used for all the assays. The markers of oxidative stress were assessed, including plasma levels of index of lipid peroxidation - thiobarbituric acid reactive substances, hydrogen peroxide, superoxide anion radical, nitrites and activity of superoxide dismutase, catalase and reduced glutathione levels as antioxidant parameters. In the patients group, levels of hydrogen peroxide and index of lipid peroxidation were higher than in controls. Patients with rheumatoid arthritis had decreased superoxide dismutase and catalase activity compared to healthy subjects. Interestingly, controls had higher levels of nitrites compared to patients. Patients showed a marked increase in reactive oxygen species formation and lipid peroxidation as well as decrease in the activity of antioxidant defense system leading to oxidative stress which may contribute to tissue and cartilage damage and hence to the chronicity of the disease.

Red cell distribution width is associated with endothelial progenitor cell depletion and vascular-related mediators in rheumatoid arthritis

2015 ◽  
Vol 240 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Javier Rodríguez-Carrio ◽  
Mercedes Alperi-López ◽  
Patricia López ◽  
Sara Alonso-Castro ◽  
Santiago Rubén Carro-Esteban ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Red Cell Distribution Width ◽  
Cell Depletion ◽  
Red Cell ◽  
Cell Distribution ◽  
Endothelial Progenitor ◽  
Distribution Width

scholarly journals SAT0111 RED CELL DISTRIBUTION WIDTH IS A MARKER OF EARLY RESPONSE TO METHOTREXATE IN RHEUMATOID ARTHRITIS

2019 ◽  
Author(s):  
Daniele Soddu ◽  
Mattia Bellan ◽  
Erika Zecca ◽  
Alessandro Croce ◽  
Roberta Pedrazzoli ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Early Response ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width

Red cell distribution width and neutrophil–lymphocyte ratio in rheumatoid arthritis

2020 ◽  
Vol 40 (10) ◽  
pp. 1631-1637
Author(s):  
Patricia Pauline M. Remalante ◽  
Evelyn O. Salido ◽  
Ester G. Penserga ◽  
Deonne Thaddeus V. Gauiran
Keyword(s):  
Rheumatoid Arthritis ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio
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