Biochemical pharmacology of total retro-inverso analogues of bradykinin and angiotensin II: Molecular recognition by G-protein-coupled receptors and angiotensin converting enzyme

1998 ◽  
Vol 5 (1) ◽  
pp. 37-41 ◽  
Author(s):  
John Howl ◽  
Mark Wheatley
Keyword(s):  
Angiotensin Ii ◽  
Molecular Recognition ◽  
Angiotensin Converting Enzyme ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
Converting Enzyme ◽  
Biochemical Pharmacology ◽  
G Protein Coupled

scholarly journals Roles of G Protein-Coupled Receptors (GPCRs) in Gastrointestinal Cancers: Focus on Sphingosine 1-Shosphate Receptors, Angiotensin II Receptors, and Estrogen-Related GPCRs

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2988
Author(s):  
Zhen Zeng ◽  
Chunxiang Ma ◽  
Kexin Chen ◽  
Mingshan Jiang ◽  
Reshma Vasu ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
Angiotensin Ii Receptors ◽  
Biological Processes ◽  
Substantial Evidence ◽  
Sphingosine 1 Phosphate ◽  
Gi Cancers ◽  
G Protein Coupled ◽  
Made In

It is well established that gastrointestinal (GI) cancers are common and devastating diseases around the world. Despite the significant progress that has been made in the treatment of GI cancers, the mortality rates remain high, indicating a real need to explore the complex pathogenesis and develop more effective therapeutics for GI cancers. G protein-coupled receptors (GPCRs) are critical signaling molecules involved in various biological processes including cell growth, proliferation, and death, as well as immune responses and inflammation regulation. Substantial evidence has demonstrated crucial roles of GPCRs in the development of GI cancers, which provided an impetus for further research regarding the pathophysiological mechanisms and drug discovery of GI cancers. In this review, we mainly discuss the roles of sphingosine 1-phosphate receptors (S1PRs), angiotensin II receptors, estrogen-related GPCRs, and some other important GPCRs in the development of colorectal, gastric, and esophageal cancer, and explore the potential of GPCRs as therapeutic targets.

scholarly journals Taste Perception: Molecular Recognition of Food Molecules

2021 ◽  
Vol 75 (6) ◽  
pp. 552-553
Author(s):  
Yvonne Westermaier
Keyword(s):  
Ion Channels ◽  
Molecular Recognition ◽  
G Protein ◽  
Chemical Nature ◽  
Molecular Level ◽  
G Protein Coupled Receptors ◽  
Taste Perception ◽  
G Protein Coupled

Molecular recognition of food molecules by ion channels and G-protein coupled receptors is the basis of taste perception. We explore the chemical nature of dietary molecules, and explore how salty, sour, sweet, bitter, and umami tastes can be explained at a molecular level.

scholarly journals Molecular recognition of ketamine by a subset of olfactory G protein–coupled receptors

2015 ◽  
Vol 8 (370) ◽  
pp. ra33-ra33 ◽  
Author(s):  
Jianghai Ho ◽  
Jose Manuel Perez-Aguilar ◽  
Lu Gao ◽  
Jeffery G. Saven ◽  
Hiroaki Matsunami ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled

G-protein-coupled receptors, channels, and Na+–H+ exchanger in nuclear membranes of heart, hepatic, vascular endothelial, and smooth muscle cellsThis paper is one of a selection of papers published in this Special Issue, entitled The Nucleus: A Cell Within A Cell.

2006 ◽  
Vol 84 (3-4) ◽  
pp. 431-441 ◽  
Author(s):  
Ghassan Bkaily ◽  
Moni Nader ◽  
Levon Avedanian ◽  
Sana Choufani ◽  
Danielle Jacques ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
G Protein ◽  
Cell Types ◽  
G Protein Coupled Receptors ◽  
Specific Cell ◽  
Endothelin 1 ◽  
Nuclear Membranes ◽  
Ionic Transporters ◽  
A Cell ◽  
G Protein Coupled

The action of several peptides and drugs is thought to be primarily dependent on their interactions with specific cell surface G-protein-coupled receptors and ionic transporters such as channels and exchangers. Recent development of 3-D confocal microscopy allowed several laboratories, including ours, to identify and study the localization of receptors, channels, and exchangers at the transcellular level of several cell types. Using this technique, we demonstrated in the nuclei of several types of cells the presence of Ca2+ channels as well as Na+–H+ exchanger and receptors such as endothelin-1 and angiotensin II receptors. Stimulation of these nuclear membrane G-protein-coupled receptors induced an increase of nuclear Ca2+. Our results suggest that, similar to the plasma membrane, nuclear membranes possess channels, exchangers and receptors such as those for endothelin-1 and angiotensin II, and that the nucleus seems to be a cell within a cell. This article will emphasize these findings.

scholarly journals Hemorphins Targeting G Protein-Coupled Receptors

2021 ◽  
Vol 14 (3) ◽  
pp. 225
Author(s):  
Mohammed Akli Ayoub ◽  
Ranjit Vijayan
Keyword(s):  
Angiotensin Ii ◽  
G Protein ◽  
Molecular Basis ◽  
Allosteric Modulation ◽  
G Protein Coupled Receptors ◽  
Beta Subunit ◽  
Short Peptides ◽  
Physiological Effects ◽  
Diverse Range ◽  
G Protein Coupled

Hemorphins are short peptides produced by the proteolysis of the beta subunit of hemoglobin. These peptides have diverse physiological effects especially in the nervous and the renin-angiotensin systems. Such effects occur through the modulation of a diverse range of proteins including enzymes and receptors. In this review, we focus on pharmacological and functional targeting of G protein-coupled receptors (GPCRs) by hemorphins and their implication in physiology and pathophysiology. Among GPCRs, the opioid receptors constitute the first set of targets of hemorphins with implication in analgesia. Subsequently, several other GPCRs have been reported to be directly or indirectly involved in hemorphins’ action. This includes the receptors for angiotensin II, oxytocin, bombesin, and bradykinin, as well as the human MAS-related G protein-coupled receptor X1. Interestingly, both orthosteric activation and allosteric modulation of GPCRs by hemorphins have been reported. This review links hemorphins with GPCR pharmacology and signaling, supporting the implication of GPCRs in hemorphins’ effects. Thus, this aids a better understanding of the molecular basis of the action of hemorphins and further demonstrates that hemorphin-GPCR axis constitutes a valid target for therapeutic intervention in different systems.

G-protein-coupled receptors for peptide hormones: angiotensin II receptors

1997 ◽  
Vol 25 (3) ◽  
pp. 1041-1046 ◽  
Author(s):  
A. J. Balmforth ◽  
A. J. Lee ◽  
F. H. Shepherd ◽  
P. Warburton ◽  
D. Donnelly ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
G Protein ◽  
Peptide Hormones ◽  
G Protein Coupled Receptors ◽  
Angiotensin Ii Receptors ◽  
G Protein Coupled
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