Efficient solid-phase synthesis of a large peptide by a single coupling protocol with a single HPLC purification step

1997 ◽  
Vol 4 (3) ◽  
pp. 141-146 ◽  
Author(s):  
Kiyoshi Nokihara ◽  
Yoshinobu Nagawa ◽  
Seon-Pyo Hong ◽  
Hiroshi Nakanishi
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Purification Step ◽  
Phase Synthesis ◽  
Hplc Purification ◽  
Single Coupling ◽  
Large Peptide

Combinatorial Solid-Phase Synthesis of 6-Aryl-1,3,5-triazines via Suzuki Coupling

2011 ◽  
Vol 64 (5) ◽  
pp. 540 ◽  
Author(s):  
Jae Wook Lee ◽  
Hyung-Ho Ha ◽  
Marc Vendrell ◽  
Jacqueline T. Bork ◽  
Young-Tae Chang
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Coupling ◽  
Structural Diversity ◽  
Suzuki Coupling ◽  
Purification Step ◽  
Solid Supports ◽  
Phase Synthesis ◽  
Triazine Derivatives ◽  
Polymer Supported

A synthetic methodology to prepare collections of trisubstituted aryl 1,3,5-triazines with broad structural diversity via Suzuki coupling has been developed. We first optimized the combinatorial derivatization of the triazine core using Suzuki cross-coupling. Second, in order to further expand the methodology for the preparation of negatively charged triazines, we adapted this approach to polymer-supported amino acids and prepared aryl triazines with different charge distribution. With a collection of 160 aryl triazine derivatives in good purities and without any purification step, we proved the viability of this orthogonal scheme for the preparation of triazine libraries using amine/amino acid-captured solid supports and Suzuki cross-coupling.

scholarly journals Solid-phase synthesis and fluorine-18 radiolabeling of cycloRGDyK

2016 ◽  
Vol 14 (37) ◽  
pp. 8659-8663 ◽  
Author(s):  
Ryan A. Davis ◽  
Kevin Lau ◽  
Sven H. Hausner ◽  
Julie L. Sutcliffe
Keyword(s):  
Peptide Synthesis ◽  
High Purity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Continuous Process ◽  
Solid Support ◽  
Purification Step ◽  
Phase Synthesis

A rapid, efficient single continuous process for peptide synthesis, cyclization, and radiolabeling on solid-support with a single purification step afforded a high purity radiotracer.

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