The role of the anionic groups in the receptor binding of interleukin-8 antagonists

1998 ◽  
Vol 5 (2-3) ◽  
pp. 235-239
Author(s):  
Katherine Widdowson ◽  
Hong Nie ◽  
Anthony J. Jurewicz ◽  
Robert P. Hertzberg ◽  
Henry M. Sarau ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Interleukin 8 ◽  
Anionic Groups

Role of key point Mutations in Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein

2020 ◽  
Vol 20 ◽  
Author(s):  
Bipin Singh
Keyword(s):  
Receptor Binding ◽  
Point Mutations ◽  
Binding Domain ◽  
Receptor Binding Domain ◽  
Spike Glycoprotein ◽  
Angiotensin Converting Enzyme 2 ◽  
Recent Outbreak ◽  
Novel Coronavirus ◽  
Genomic Similarity

: The recent outbreak of novel coronavirus (SARS-CoV-2 or 2019-nCoV) and its worldwide spread is posing one of the major threats to human health and the world economy. It has been suggested that SARS-CoV-2 is similar to SARSCoV based on the comparison of the genome sequence. Despite the genomic similarity between SARS-CoV-2 and SARSCoV, the spike glycoprotein and receptor binding domain in SARS-CoV-2 shows the considerable difference compared to SARS-CoV, due to the presence of several point mutations. The analysis of receptor binding domain (RBD) from recently published 3D structures of spike glycoprotein of SARS-CoV-2 (Yan, R., et al. (2020); Wrapp, D., et al. (2020); Walls, A. C., et al. (2020)) highlights the contribution of a few key point mutations in RBD of spike glycoprotein and molecular basis of its efficient binding with human angiotensin-converting enzyme 2 (ACE2).

scholarly journals The role of endothelial interleukin-8/NADPH oxidase 1 axis in sepsis

Immunology ◽  
2010 ◽  
Vol 131 (3) ◽  
pp. 331-339 ◽  
Author(s):  
Takashi Miyoshi ◽  
Kouhei Yamashita ◽  
Toshiyuki Arai ◽  
Kokichi Yamamoto ◽  
Kiyomi Mizugishi ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Interleukin 8 ◽  
Nadph Oxidase 1

scholarly journals Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding.

1991 ◽  
Vol 266 (28) ◽  
pp. 18989-18994 ◽  
Author(s):  
C.A. Hébert ◽  
R.V. Vitangcol ◽  
J.B. Baker
Keyword(s):  
Receptor Binding ◽  
Interleukin 8

Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants

2007 ◽  
Vol 1774 (8) ◽  
pp. 1029-1035 ◽  
Author(s):  
Hiroko Shibata ◽  
Haruhiko Kamada ◽  
Kyoko Kobayashi-Nishibata ◽  
Yasuo Yoshioka ◽  
Toshihide Nishibata ◽  
...  
Keyword(s):  
Amino Acid ◽  
Tumor Necrosis Factor ◽  
Receptor Binding ◽  
Amino Acid Residue ◽  
Tumor Necrosis ◽  
Binding Capacity ◽  
Necrosis Factor
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