Interaction of 24,25-Dihydroxyvitamin D3 and parathyroid hormone on bone enzymes in vitro

1979 ◽  
Vol 27 (1) ◽  
pp. 47-52 ◽  
Author(s):  
M. Lieberherr ◽  
M. Garabédian ◽  
H. Guillozo ◽  
M. Bailly du Bois ◽  
S. Balsan
Keyword(s):  
Parathyroid Hormone ◽  
Dihydroxyvitamin D3 ◽  
24,25 Dihydroxyvitamin D3

1α, 25-Dihydroxyvitamin D3, and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta

Nature ◽  
1979 ◽  
Vol 281 (5729) ◽  
pp. 317-319 ◽  
Author(s):  
Y. Weisman ◽  
A. Harell ◽  
S. Edelstein ◽  
M. David ◽  
Z. Spirer ◽  
...  
Keyword(s):  
Dihydroxyvitamin D3 ◽  
In Vitro Synthesis ◽  
Human Decidua ◽  
24,25 Dihydroxyvitamin D3

Effects of chlorothiazide on 1,25-dihydroxyvitamin D3, parathyroid hormone, and intestinal calcium absorption in the rat

1982 ◽  
Vol 242 (6) ◽  
pp. G575-G581 ◽  
Author(s):  
M. J. Favus ◽  
F. L. Coe ◽  
S. C. Kathpalia ◽  
A. Porat ◽  
P. K. Sen ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Calcium Absorption ◽  
Intestinal Calcium Absorption ◽  
Idiopathic Hypercalciuria ◽  
Calcium Excretion ◽  
Dihydroxyvitamin D3 ◽  
Ussing Chambers ◽  
1,25 Dihydroxyvitamin D3 ◽  
Descending Colon

Previous studies have shown that thiazide diuretic agents reverse secondary hyperparathyroidism and reduce circulating 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and intestinal calcium absorption rates in patients with idiopathic hypercalciuria of the renal-leak variety. We have investigated whether thiazides can reverse the secondary increase in serum parathyroid hormone (PTH) and 1,25(OH)2D3 levels or intestinal calcium absorption induced by feeding rats a diet low in calcium (LCD, 0.02% calcium) but adequate in phosphorus and vitamin D. We found that LCD increased circulating immunoreactive PTH [chow vs. LCD, 0.52 +/- 0.06 vs. 1.06 +2- 0.1 (SE) ng/ml, P less than 0.001], 1,25(OH)2D3 (chow vs. LCD, 101 +/- 15 vs. 325 +/- 38 pg/ml, P less than 0.001), calcium uptake by everted gut sacs from duodenum, ileum, and descending colon, and net calcium absorption by descending colon studied in Ussing chambers in vitro. Chlorothiazide (CTZ) prevented the increase in PTH during LCD (chow + CTZ vs. LCD + CTZ, 0.69 +/- 0.07 vs. 0.73 +/- 0.06, NS) but not the increase in 1,25(OH)2D3 (chow + CTZ vs. LCD + CTZ, 88 +/- 10 vs. 277 +/- 31, P less than 0.002) or intestinal calcium transport. The drug caused no change in serum 1,25(OH)2D3 or intestinal calcium absorption in rats fed normal chow. In rats given exogenous 1,25(OH)2D3 to stimulate intestinal calcium absorption, CTZ reduced urine calcium excretion greatly but did not alter intestinal calcium absorption.

Lack of influence of 24,25-dihydroxyvitamin D3 on parathyroid hormone secretion from normal or hyperplastic glands

1983 ◽  
Vol 35 (1) ◽  
pp. 449-454 ◽  
Author(s):  
Marcos Rothstein ◽  
Klaus Olgaard ◽  
Mario Arbelaez ◽  
Delmar Finco ◽  
Saulo Klahr ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Hormone Secretion ◽  
Dihydroxyvitamin D3 ◽  
24,25 Dihydroxyvitamin D3

Effect of vitamin D3, 25-hydroxyvitamin D3, and 24,25-dihydroxyvitamin D3 on parathyroid hormone secretion

1987 ◽  
Vol 41 (1) ◽  
pp. 48-51 ◽  
Author(s):  
Larry K. Cantley ◽  
John B. Russell ◽  
Deborah S. Lettieri ◽  
Louis M. Sherwood
Keyword(s):  
Parathyroid Hormone ◽  
Vitamin D3 ◽  
Hormone Secretion ◽  
Dihydroxyvitamin D3 ◽  
24,25 Dihydroxyvitamin D3

Influence of estrogen on renal vitamin D hydroxylases and serum 1alpha,25-(OH)2D3 in chicks.

1978 ◽  
Vol 235 (3) ◽  
pp. E338 ◽  
Author(s):  
J W Pike ◽  
E Spanos ◽  
K W Colston ◽  
I MacIntyre ◽  
M R Haussler
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Vitamin D3 ◽  
Steroid Treatment ◽  
Vitamin D Metabolism ◽  
Dihydroxyvitamin D3 ◽  
Chick Kidney ◽  
24,25 Dihydroxyvitamin D3

The influence of estrogen on the metabolism of 25-hydroxyvitamin D3 was studied in 2- to 5-wk-old chicks. Single injections of at least 500 microgram diethylstibestrol (DES) increased the conversion of 25-hydroxyvitamin D3 to 1alpha,25-dihydroxyvitamin D3 (1alpha,25-(OH)2D3) and suppressed the production of 24,25-dihydroxyvitamin D3 in chick kidney homogenates. Acute (one 5-mg) injections of testosterone or progesterone did not enhance the 25-hydroxyvitamin D3-1alpha-hydroxylase, indicating specificity. However, chronic pretreatment with DES appeared to allow the potentiation of previously unstimulatory steroids such as progesterone and testosterone. In addition, the hormonal metabolite of vitamin D3, 1alpha,25-(OH)2D3, was measured in 4- to 6-wk chick plasma after steroid treatment. Greater than 1 mg DES per day for 5 days was necessary to enhance the circulating level of 1alpha,25-(OH)2D3; testosterone alone had no effect. This elevation was rapid, occurring within 12--24 h after injection. These data suggest that estrogen (as evidenced by DES treatment) is a modulator of vitamin D metabolism along with other known regulators such as parathyroid hormone, phosphate, and 1alpha,25-(OH)2D3. The mechanism of the regulation is as yet unknown.

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