Changes in thermonociceptive thresholds and the role of enkephalinase A in homeostasis in morphine-tolerant rat offspring

2000 ◽  
Vol 129 (5) ◽  
pp. 474-476
Author(s):  
S. V. Litvinova ◽  
V. V. Aristova ◽  
V. V. Shulgovskii ◽  
N. N. Terebilina ◽  
L. F. Panchenko
Keyword(s):  
Rat Offspring ◽  
Enkephalinase A

scholarly journals The Protective Role of Prenatal Alpha Lipoic Acid Supplementation against Pancreatic Oxidative Damage in Offspring of Valproic Acid-Treated Rats: Histological and Molecular Study

Biology ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 239
Author(s):  
Fatma M. Ghoneim ◽  
Hani Alrefai ◽  
Ayman Z. Elsamanoudy ◽  
Salwa M. Abo El-khair ◽  
Hanaa A. Khalaf
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Lipoic Acid ◽  
Caspase 3 ◽  
Protective Role ◽  
Alpha Lipoic Acid ◽  
Group Iii ◽  
Rat Offspring ◽  
Group I

Background: Sodium valproate (VPA) is an antiepileptic drug (AED) licensed for epilepsy and used during pregnancy in various indications. Alpha-lipoic acid (ALA) is a natural compound inducing endogenous antioxidant production. Our study aimed to investigate the effect of prenatal administration of VPA on the pancreas of rat offspring and assess the potential protective role of ALA co-administration during pregnancy. Methods: Twenty-eight pregnant female albino rats were divided into four groups: group I (negative control), group II (positive control, ALA treated), group III (VPA-treated), and group IV (VPA-ALA-treated). The pancreases of the rat offspring were removed at the fourth week postpartum and prepared for histological, immune-histochemical, morphometric, molecular, and oxidative stress marker studies. Results: In group III, there were pyknotic nuclei, vacuolated cytoplasm with ballooning of acinar, α, and β cells of the pancreas. Ultrastructural degeneration of cytoplasmic organelles was detected. Additionally, there was a significant increase in oxidative stress, a decrease in insulin-positive cell percentage, and an increase in glucagon positive cells in comparison to control groups. Moreover, VPA increased the gene expression of an apoptotic marker, caspase-3, with a decrease in anti-apoptotic Bcl2 and nuclear factor erythroid 2-related factor 2 (Nrf2) transcriptional factor. Conversely, ALA improved oxidative stress and apoptosis in group VI, and a consequent improvement of the histological and ultrastructure picture was detected. Conclusion: ALA co-administration with VPA significantly improved the oxidative stress condition, histological and morphometric picture of the pancreas, and restored normal expression of related genes, including Nrf2, caspase-3, and Bcl-2. Administration of α-lipoic acid has a protective effect against VPA-induced pancreatic oxidative damage via its cytoprotective antioxidant effect.

Role of a Maternal Diet High in Linoleic Acid on the Plasma Fatty Acid Composition in Rat Offspring

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Nirajan Shrestha ◽  
Simone Sleep ◽  
James S.M. Cuffe ◽  
Olivia J. Holland ◽  
Anthony V. Perkins ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Acid Composition ◽  
Maternal Diet ◽  
Plasma Fatty Acid ◽  
Rat Offspring ◽  
Plasma Fatty Acid Composition

Transcriptional response of skeletal muscle to a low protein perinatal diet in rat offspring at different ages: The role of key enzymes of glucose-fatty acid oxidation

2017 ◽  
Vol 41 ◽  
pp. 117-123 ◽  
Author(s):  
José Luiz de Brito Alves ◽  
Ana Elisa Toscano ◽  
João Henrique da Costa-Silva ◽  
Hubert Vidal ◽  
Carol Góis Leandro ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Transcriptional Response ◽  
Acid Oxidation ◽  
Key Enzymes ◽  
Rat Offspring ◽  
Low Protein ◽  
Different Ages

scholarly journals Role of DNA methylation in perinatal nicotine-induced development of heart ischemia-sensitive phenotype in rat offspring

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 76865-76880 ◽  
Author(s):  
Jun Ke ◽  
Nianguo Dong ◽  
Lei Wang ◽  
Yong Li ◽  
Chiranjib Dasgupta ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Rat Offspring ◽  
Heart Ischemia

scholarly journals The role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring

2021 ◽  
Author(s):  
Samantha C. Lauby ◽  
David G. Ashbrook ◽  
Hannan R. Malik ◽  
Diptendu Chatterjee ◽  
Pauline Pan ◽  
...  
Keyword(s):  
Later Life ◽  
Female Rat ◽  
Rat Offspring
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