Analysis of age-associated mitochondrial DNA deletion breakpoint regions from mice suggests a novel model of deletion formation

AGE ◽  
1996 ◽  
Vol 19 (4) ◽  
pp. 117-128 ◽  
Author(s):  
Susan S. Chung ◽  
Peter M. Eimon ◽  
Richard Weindruch ◽  
Judd M. Aiken
Keyword(s):  
Mitochondrial Dna ◽  
Deletion Breakpoint ◽  
Mitochondrial Dna Deletion ◽  
Deletion Formation ◽  
Dna Deletion ◽  
Novel Model

scholarly journals Mechanisms of Mitochondrial DNA Deletion Formation

2019 ◽  
Vol 35 (3) ◽  
pp. 235-244 ◽  
Author(s):  
Nadee Nissanka ◽  
Michal Minczuk ◽  
Carlos T. Moraes
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Dna Deletion ◽  
Deletion Formation ◽  
Dna Deletion

scholarly journals Mechanisms of replication and repair in mitochondrial DNA deletion formation

2020 ◽  
Vol 48 (20) ◽  
pp. 11244-11258
Author(s):  
Gabriele A Fontana ◽  
Hailey L Gahlon
Keyword(s):  
Dna Damage ◽  
Mitochondrial Dna ◽  
Large Scale ◽  
Molecular Mechanisms ◽  
Mitochondrial Dna Deletion ◽  
Deletion Formation ◽  
Dna Deletion ◽  
Mtdna Deletions ◽  
Mtdna Deletion

Abstract Deletions in mitochondrial DNA (mtDNA) are associated with diverse human pathologies including cancer, aging and mitochondrial disorders. Large-scale deletions span kilobases in length and the loss of these associated genes contributes to crippled oxidative phosphorylation and overall decline in mitochondrial fitness. There is not a united view for how mtDNA deletions are generated and the molecular mechanisms underlying this process are poorly understood. This review discusses the role of replication and repair in mtDNA deletion formation as well as nucleic acid motifs such as repeats, secondary structures, and DNA damage associated with deletion formation in the mitochondrial genome. We propose that while erroneous replication and repair can separately contribute to deletion formation, crosstalk between these pathways is also involved in generating deletions.

scholarly journals Roles of the mitochondrial replisome in mitochondrial DNA deletion formation

2020 ◽  
Vol 43 (1 suppl 1) ◽  
Author(s):  
Marcos T. Oliveira ◽  
Carolina de Bovi Pontes ◽  
Grzegorz L. Ciesielski
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Dna Deletion ◽  
Deletion Formation ◽  
Dna Deletion

scholarly journals Neuropathological and Histochemical Changes in a Multiple Mitochondrial DNA Deletion Disorder

2000 ◽  
Vol 59 (7) ◽  
pp. 621-627 ◽  
Author(s):  
D. A. Cottrell ◽  
P. G. Ince ◽  
E. L. Blakely ◽  
M. A. Johnson ◽  
P. F. Chinnery ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion ◽  
Histochemical Changes

Conventional MRI and MR spectroscopy in nonclassical mitochondrial disease: report of three patients with mitochondrial DNA deletion

2006 ◽  
Vol 22 (10) ◽  
pp. 1355-1359 ◽  
Author(s):  
Leonardo Vedolin ◽  
Carolina Fischinger Moura de Souza ◽  
Rogério Schwark ◽  
Bianca Lopes ◽  
Leticia Saldanha Laybauer ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Disease ◽  
Mr Spectroscopy ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion ◽  
Conventional Mri
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