Additive effects of clonidine and antidepressant drugs in the mouse forced-swimming test

1988 ◽  
Vol 96 (1) ◽  
pp. 104-109 ◽  
Author(s):  
M. Malinge ◽  
M. Bourin ◽  
M. C. Colombel ◽  
C. Larousse
Keyword(s):  
Forced Swimming Test ◽  
Antidepressant Drugs ◽  
Forced Swimming ◽  
Additive Effects ◽  
Swimming Test

The additive effects of quinine on antidepressant drugs in the forced swimming test in mice

1995 ◽  
Vol 121 (2) ◽  
pp. 173-179 ◽  
Author(s):  
W. Y. Guo ◽  
K. G. Todd ◽  
M. Bourin ◽  
M. Hascoet
Keyword(s):  
Forced Swimming Test ◽  
Antidepressant Drugs ◽  
Forced Swimming ◽  
Additive Effects ◽  
Swimming Test

scholarly journals Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test

2007 ◽  
Vol 22 (5) ◽  
pp. 351-354 ◽  
Author(s):  
Leandro Ciulla ◽  
Honório Sampaio Menezes ◽  
Bárbara Beatriz Moreira Bueno ◽  
Alexandre Schuh ◽  
Rafael José Vargas Alves ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Forced Swimming Test ◽  
Antidepressant Drugs ◽  
Forced Swimming ◽  
Behavioral Effects ◽  
Control Group ◽  
Male Wistar Rats ◽  
Swimming Test

PURPOSE: To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS: Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. RESULTS: Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significanlty reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48). CONCLUSION: Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.

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