Effects of pimozide, across doses and within sessions, on discriminated lever release performance in rats

1988 ◽  
Vol 96 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Paul Skjoldager ◽  
Stephen C. Fowler
Keyword(s):  
Lever Release

A new choice reaction-time task in the rat using air-puff stimuli and lever-release responses

2007 ◽  
Vol 58 ◽  
pp. S212
Author(s):  
Hidekazu Kaneko ◽  
Hiroshi Tamura ◽  
Takahiro Kawashima ◽  
Shinya S. Suzuki
Keyword(s):  
Reaction Time ◽  
Choice Reaction Time ◽  
Reaction Time Task ◽  
Choice Reaction Time Task ◽  
Time Task ◽  
Lever Release

Amphetamine, cocaine, and dizocilpine enhance performance on a lever-release, conditioned avoidance response task in rats

1995 ◽  
Vol 118 (3) ◽  
pp. 324-331 ◽  
Author(s):  
I. M. White ◽  
J. R. Christensen ◽  
G. S. Flory ◽  
D. W. Miller ◽  
G. V. Rebec
Keyword(s):  
Avoidance Response ◽  
Conditioned Avoidance ◽  
Conditioned Avoidance Response ◽  
Response Task ◽  
Lever Release

Properties of neuronal activity related to a visual reaction time task in the monkey prefrontal cortex

1987 ◽  
Vol 58 (5) ◽  
pp. 1080-1099 ◽  
Author(s):  
T. Sawaguchi
Keyword(s):  
Prefrontal Cortex ◽  
Reaction Time ◽  
Neuronal Activity ◽  
Decay Time ◽  
Reaction Time Task ◽  
Visual Reaction Time ◽  
Phase Type ◽  
Visual Reaction ◽  
Monkey Prefrontal Cortex ◽  
Lever Release

1. Quantitative properties of neuronal activity related to a visual reaction time task were studied in the monkey prefrontal cortex. The task consisted of an initial waiting phase (3.0-s period), a warning phase (green lamp, a variable period of 1.5-3.5 s), a go phase (red lamp), and a reward phase. 2. A total of 189 task-related neurons showed 233 changes in discharge rates during the warning (n = 86), GO (n = 103), and reward (n = 44) phases of the task. Most of the task-related neurons (145/189, 77%) showed changes during only one of the task phases, and were designated W (warning phase)-type (n = 42), GO (go phase)-type (n = 59), and RE (reward phase)-type (n = 44) neurons. The remainder (n = 44, 23%) showed changes during both the warning and the go phases, and were designated WG (warning and go phase)-type neurons. In each phase, onset latencies, peak latencies, and decay times of each change were measured and compared. 3. The changes during the warning phase (n = 86) were separated into three groups based on decay time; that is, phasic changes (n = 31), phasic-tonic changes (n = 23), and tonic changes (n = 32). Onset latencies and peak latencies were homogeneously distributed, and there were no clear groupings, although phasic and phasic-tonic changes tended to show shorter latencies than tonic changes. 4. The changes during the go phase (n = 103) did not show distinct differences, either in terms of decay time or of latency. The changes during the go phase showed various degrees of coupling to both the visual go signal (GS) and lever-release hand movement. To quantitate the coupling, a value to indicate the degrees of coupling (coupling index) was calculated. The changes coupled more strongly to the GS (cue coupled), those coupled more closely to the lever release (movement coupled), and intermediate changes could be distinguished from each other. The cue-coupled changes showed shorter latencies from the time onset of the GS than the movement-coupled changes, and the intermediate changes showed intermediate latencies. The decay time and the duration of the intermediate changes were longer than those of the cue-coupled changes and the movement-coupled changes. 5. The properties of WG-type neurons were compared with those of W-type and GO-type neurons.(ABSTRACT TRUNCATED AT 400 WORDS)

scholarly journals 0224 Optogenetic Manipulation of Basal Forebrain Parvalbumin Neurons Modulates Vigilant Attention and Rescues Sleep Deprivation Induced Impairments

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A87-A87
Author(s):  
F L Schiffino ◽  
J M McNally ◽  
A N Hassler ◽  
R E Brown ◽  
R E Strecker
Keyword(s):  
Reaction Time ◽  
Sleep Deprivation ◽  
Basal Forebrain ◽  
Green Light ◽  
Reaction Times ◽  
Reaction Time Task ◽  
Vigilance Task ◽  
Cortical Activation ◽  
Light Onset ◽  
Lever Release

Abstract Introduction Sleep disruption leads to attention impairments, excessive daytime sleepiness, and is a major contributor to accident rates and decreased workplace productivity. The basal forebrain (BF) region has long been associated with promoting cortical arousal and wakefulness. Recently, selective excitation of BF parvalbumin (PV) GABAergic neurons has been shown to produce high frequency cortical activation and brief periods of wakefulness. Here we test the hypothesis that BF PV neurons are involved in vigilant attention using bidirectional optogenetic manipulations in a signaled reaction time task. Methods Brief optogenetic excitation (ChR2) and inhibition (ArchT) of BF PV neurons was applied during a lever release version of the rodent psychomotor vigilance task (rPVT). Mice were trained to hold a lever down to initiate a trial and after a random delay, a 200ms cue light signaled the mouse to quickly release the lever within 1s to receive a sucrose pellet reward. The reaction time between cue light onset and lever release was the primary measure of attentional performance. Sleep deprivation (8h) produced by gentle handling was also investigated. Laser parameters: brief (1s) of continuous (non-pulsatile) laser stimulation was delivered beginning 500ms prior to cue light onset (5mW 473nm blue light for ChR2-mediated excitation; 10mW 530nm green light for ArchT-mediated inhibition). Results BF PV excitation led to faster reactions times (N=6, 14% faster, p<.001), interpreted as an enhancement of attention. Sleep deprivation slowed reaction times (20% slower, p<.01) and BF PV excitation rescued the sleep deprivation induced impairments. BF PV inhibition significantly slowed reaction times (25% slower, p<.02), an effect that resembled the effects of sleep deprivation. Conclusion This is the first demonstration of a role for BF PV neurons in attention and in the attention deficits produced by sleep deprivation. Support T32 HL007901, I01 BX002774, P01 HL095491, R01 MH039683, I01 BX004500, IK2 BX002130, Stonehill College SURE program, I01 BX001356

Motor effects of pimozide on discriminated lever release in rats

1987 ◽  
Vol 27 (3) ◽  
pp. 589
Author(s):  
Stephen C. Fowler ◽  
Paul Skjoldager
Keyword(s):  
Motor Effects ◽  
Lever Release
Sign in / Sign up

Export Citation Format

Share Document