The expression of GABAA receptor subunits in the substantia nigra is developmentally regulated and region-specific

1998 ◽  
Vol 19 (4) ◽  
pp. 205-210 ◽  
Author(s):  
J. Veĺišková ◽  
E. F. Sperber ◽  
S. L. Moshé ◽  
H. Kubová ◽  
L. K. Friedman ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Gabaa Receptor ◽  
Developmentally Regulated ◽  
Gabaa Receptor Subunits

scholarly journals Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds

2013 ◽  
Vol 16 (6) ◽  
pp. 1361-1371 ◽  
Author(s):  
Caroline Nothdurfter ◽  
Sascha Tanasic ◽  
Barbara Di Benedetto ◽  
Manfred Uhr ◽  
Eva-Maria Wagner ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Lipid Rafts ◽  
Gabaa Receptor ◽  
Lipid Raft ◽  
Tricyclic Antidepressant ◽  
Membrane Microdomains ◽  
Cholesterol Depletion ◽  
Receptor Modulation ◽  
Gabaa Receptor Subunits ◽  
Triton X

Abstract Lipid rafts have been shown to play an important role for G-protein mediated signal transduction and the function of ligand-gated ion channels including their modulation by psychopharmacological compounds. In this study, we investigated the functional significance of the membrane distribution of NMDA and GABAA receptor subunits in relation to the accumulation of the tricyclic antidepressant desipramine (DMI) and the benzodiazepine diazepam (Diaz). In the presence of Triton X-100, which allowed proper separation of the lipid raft marker proteins caveolin-1 and flotillin-1 from the transferrin receptor, all receptor subunits were shifted to the non-raft fractions. In contrast, under detergent-free conditions, NMDA and GABAA receptor subunits were detected both in raft and non-raft fractions. Diaz was enriched in non-raft fractions without Triton X-100 in contrast to DMI, which preferentially accumulated in lipid rafts. Impairment of lipid raft integrity by methyl-β-cyclodextrine (MβCD)-induced cholesterol depletion did not change the inhibitory effect of DMI at the NMDA receptor, whereas it enhanced the potentiating effect of Diaz at the GABAA receptor at non-saturating concentrations of GABA. These results support the hypothesis that the interaction of benzodiazepines with the GABAA receptor likely occurs outside of lipid rafts while the antidepressant DMI acts on ionotropic receptors both within and outside these membrane microdomains.

scholarly journals Contribution of GABAA receptor subunits to attention and social behavior

2020 ◽  
Vol 378 ◽  
pp. 112261
Author(s):  
Tracie A. Paine ◽  
Sara Chang ◽  
Rachel Poyle
Keyword(s):  
Social Behavior ◽  
Gabaa Receptor ◽  
Gabaa Receptor Subunits

Variable colocalisation of GABAA receptor subunits and glycine receptors on neurons in the human hypoglossal nucleus

2019 ◽  
Vol 97 ◽  
pp. 99-111 ◽  
Author(s):  
H.J. Waldvogel ◽  
F.M. Biggins ◽  
A. Singh ◽  
C.J. Arasaratnam ◽  
R.L.M. Faull
Keyword(s):  
Gabaa Receptor ◽  
Hypoglossal Nucleus ◽  
Glycine Receptors ◽  
Gabaa Receptor Subunits
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