Utility of SPECT imaging for determination of vertebral metastases in patients with known primary tumors

1995 ◽  
Vol 24 (1) ◽  
pp. 13-16 ◽  
Author(s):  
D. L. Bushnell ◽  
D. Kahn ◽  
B. Huston ◽  
C. G. Bevering
Keyword(s):  
Spect Imaging ◽  
Vertebral Metastases ◽  
Primary Tumors

scholarly journals Advancements in PARP1 Targeted Nuclear Imaging and Theranostic Probes

2020 ◽  
Vol 9 (7) ◽  
pp. 2130
Author(s):  
Ramya Ambur Sankaranarayanan ◽  
Susanne Kossatz ◽  
Wolfgang Weber ◽  
Mohsen Beheshti ◽  
Agnieszka Morgenroth ◽  
...  
Keyword(s):  
Nuclear Dna ◽  
Parp Inhibitor ◽  
Nuclear Imaging ◽  
Diagnostic Value ◽  
Parp Inhibition ◽  
Primary Tumors ◽  
Imaging Probes ◽  
Parp1 Inhibitors ◽  
Central Paradigm

The central paradigm of novel therapeutic approaches in cancer therapy is identifying and targeting molecular biomarkers. One such target is the nuclear DNA repair enzyme Poly-(ADP ribose) polymerase 1 (PARP1). Sensitivity to PARP inhibition in certain cancers such as gBRCAmut breast and ovarian cancers has led to its exploitation as a target. The overexpression of PARP1 in several types of cancer further evoked interest in its use as an imaging target. While PARP1-targeted inhibitors have fast developed and approved in this past decade, determination of PARP1 expression might help to predict the response to PARP inhibitor treatment. This has the potential of improving prognosis and moving towards tailored therapy options and/or dosages. This review summarizes the recent pre-clinical advancements in imaging and theranostic PARP1 targeted tracers. To assess PARP1 levels, several imaging probes with fluorescent or beta/gamma emitting radionuclides have been proposed and three have advanced to ongoing clinical evaluation. Apart from its diagnostic value in detection of primary tumors as well as metastases, this shall also help in delivering therapeutic radionuclides to PARP1 overexpressing tumors. Henceforth nuclear medicine has now advanced towards conjugating theranostic radionuclides to PARP1 inhibitors. This paves the way for a future of PARP1-targeted theranostics and personalized therapy.

scholarly journals The Diagnosis and Clinical Significance of Paragangliomas in Unusual Locations

2018 ◽  
Vol 7 (9) ◽  
pp. 280 ◽  
Author(s):  
Sylvia Asa ◽  
Shereen Ezzat ◽  
Ozgur Mete
Keyword(s):  
Malignant Disease ◽  
Correct Diagnosis ◽  
Neuroendocrine Neoplasms ◽  
Clinical Implications ◽  
Bladder Tumors ◽  
Primary Tumors ◽  
Anatomic Locations ◽  
The Impact

Paragangliomas are neuroendocrine neoplasms, derived from paraganglia of the sympathetic and parasympathetic nervous systems. They are most commonly identified in the head and neck, being most frequent in the carotid body, followed by jugulotympanic paraganglia, vagal nerve and ganglion nodosum, as well as laryngeal paraganglia. Abdominal sites include the well-known urinary bladder tumors that originate in the Organ of Zuckerkandl. However, other unusual sites of origin include peri-adrenal, para-aortic, inter-aortocaval, and paracaval retroperitoneal sites, as well as tumors in organs where they may not be expected in the differential diagnosis of neuroendocrine neoplasms, such as thyroid, parathyroid, pituitary, gut, pancreas, liver, mesentery, lung, heart and mediastinum. The distinction of these lesions from epithelial neuroendocrine neoplasms is critical for several reasons. Firstly, the determination of clinical and biochemical features is different from that used for epithelial neuroendocrine tumors. Secondly, the genetic implications are different, since paragangliomas/pheochromocytomas have the highest rate of germline susceptibility at almost 40%. Finally, the characterization of metastatic disease is unique in these highly syndromic lesions. In this review, we summarize updated concepts by outlining the spectrum of anatomic locations of paragangliomas, the importance of morphology in establishing the correct diagnosis, the clinical implications for management, and the impact of genetics on the distinction between multifocal primary tumors compared with malignant disease.

Determination of the Optimum Filter Parameters for Cerebral SPECT Imaging

NeuroImage ◽  
1998 ◽  
Vol 7 (4) ◽  
pp. S640
Author(s):  
Phys. Ivanei E. Bramati ◽  
Paulo B. de Abreu ◽  
Dra. Ana L. Baron ◽  
Pedro Ferreira ◽  
Renato Cunha
Keyword(s):  
Spect Imaging ◽  
Optimum Filter

scholarly journals Targeted Sequencing of Pancreatic Adenocarcinomas from Patients with Metachronous Pulmonary Metastases

Genes ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1391
Author(s):  
Viktor Hlavac ◽  
Beatrice Mohelnikova-Duchonova ◽  
Martin Lovecek ◽  
Jiri Ehrmann ◽  
Veronika Brynychova ◽  
...  
Keyword(s):  
Pulmonary Metastases ◽  
Digital Pcr ◽  
Median Number ◽  
Targeted Sequencing ◽  
Ductal Adenocarcinoma ◽  
Primary Tumors ◽  
Individual Gene ◽  
Cancer Driver ◽  
Mutation Spectra

Mutation spectra of 250 cancer driver, druggable, and actionable genes were analyzed in surgically resected pancreatic ductal adenocarcinoma (PDAC) patients who developed metachronous pulmonary metastases. Targeted sequencing was performed in DNA from blood and archival samples of 15 primary tumors and three paired metastases. Results were complemented with the determination of G12V mutation in KRAS by droplet digital PCR. The median number of protein-changing mutations was 52 per patient. KRAS and TP53 were significantly enriched in fractions of mutations in hotspots. Individual gene mutation frequencies or mutational loads accounting separately for drivers, druggable, or clinically actionable genes, did not significantly associate with patients’ survival. LRP1B was markedly mutated in primaries of patients who generalized (71%) compared to those developing solitary pulmonary metastases (0%). FLG2 was mutated exclusively in primary tumors compared to paired metastases. In conclusion, signatures of prognostically differing subgroups of PDAC patients were generated for further utilization in precision medicine.

Determination of left ventricular mass through SPECT imaging

1998 ◽  
Author(s):  
A. Zárate-Morales ◽  
M. Rodrı́guez-Villafuerte ◽  
F. Martı́nez-Rodrı́guez ◽  
N. Arévila-Ceballos
Keyword(s):  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Spect Imaging ◽  
Ventricular Mass

scholarly journals Correlation between actual survival and Tokuhashi and tomita scores in spine metastases

2015 ◽  
Vol 14 (2) ◽  
pp. 138-143 ◽  
Author(s):  
Alexandre Henrique Silveira Bechara ◽  
André Frazão Rosa ◽  
Marcelo Ítalo Risso Neto ◽  
Marcos Antônio Tebet ◽  
Ivan Guidolin Veiga ◽  
...  
Keyword(s):  
Tumor Metastasis ◽  
Good Accuracy ◽  
Spinal Metastases ◽  
Vertebral Metastases ◽  
Correct Classification ◽  
Primary Tumors ◽  
Risk Of Death ◽  
Retrospective Assessment ◽  
The Mean ◽  
Actual Survival

<sec><title>OBJECTIVE:</title><p> To evaluate the accuracy of the scores of Tokuhashi and Tomita and the actual survival of patients with vertebral metastases.</p></sec><sec><title>METHODS:</title><p> A retrospective assessment of 45 patients with spinal metastases. Thirty-one patients underwent surgical treatment and adjuvant therapy and 14 received conservative treatment (chemotherapy/radiotherapy) or palliative/supportive, depending on the scores of Tokuhashi and Tomita.</p></sec><sec><title>RESULTS:</title><p> In the study, 80% of patients were female and the mean age was 57.8 years (SD=11.3 years). The most frequent primary tumors were breast and prostate (68.9%). The accuracy of Tokuhashi scale was 53.4% and the Tomita, 64.5%. The concentration of Tomita range of correct classification was in the category of survival > 12 months (57.8%), while the Tokuhashi scale presented some adjustment in the other categories, < 6 months (15.6%) and 6 to 12 months (2.2%). The histological type of the primary tumor was the only variable that statistically influenced the survival time of patients (p<0.001), and patients with lung or liver tumor (most aggressive) presented a risk of death 9.89 times higher than patients with primary tumors of breast or prostate (less aggressive) (95% CI: 3.10 to 31.57).</p></sec><sec><title>CONCLUSION:</title><p> The Tokuhashi and Tomita scores showed good accuracy with respect to the actual survival of patients with tumor metastasis in the spine.</p></sec>

Automated Volume Determination of the Liver and Spleen from Tc-99m Colloid SPECT Imaging Quantification of the Liver Functional and Nonfunctional Tissue in Disease

1990 ◽  
Vol 15 (7) ◽  
pp. 495-500 ◽  
Author(s):  
G. J. KAVANAGH ◽  
J. T. KAVANAGH ◽  
P. B. K. KAVANAGH ◽  
L E. IRWIN ◽  
A. C. PERKINS ◽  
...  
Keyword(s):  
Spect Imaging ◽  
Volume Determination
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