Regulation of hormone-induced cyclic AMP response to parathyroid hormone and prostaglandin E2 in cells cultured from human giant cell tumors of bone

1979 ◽  
Vol 29 (1) ◽  
pp. 193-200 ◽  
Author(s):  
Steven R. Goldring ◽  
Jean-Michel Dayer ◽  
Stephen M. Krane
Keyword(s):  
Parathyroid Hormone ◽  
Cyclic Amp ◽  
Prostaglandin E2 ◽  
Giant Cell ◽  
Giant Cell Tumors ◽  
Tumors Of Bone ◽  
Cells Cultured ◽  
In Cells

Parathyroid hormone modulates protein kinase in giant cell tumors of human bone

1980 ◽  
Vol 239 (2) ◽  
pp. E144-E149 ◽  
Author(s):  
D. A. Ausiello ◽  
M. Rosenblatt ◽  
J. M. Dayer
Keyword(s):  
Parathyroid Hormone ◽  
Protein Kinase ◽  
Cyclic Amp ◽  
Giant Cell ◽  
Giant Cell Tumors ◽  
Dependent Protein Kinase ◽  
Protein Substrates ◽  
Endogenous Protein ◽  
Dependent Protein ◽  
Tumors Of Bone

The physiological effects of parathyroid hormone (PTH) in bone are mediated at least in part by cyclic AMP. The biochemical events subsequent to this step have not been well characterized in this tissue. Giant cell tumors of bone (GT) increase cyclic AMP in response to PTH. This response can be inhibited by an analogue of bovine PTH, [Nle8, Nle18, Tyr34] bPTH-(3-34) amide (PTH-Inh). Cyclic AMP content and cyclic AMP-dependent protein kinase (cAMP-PK) were assayed in fresh tumors and cells in culture incubated with 1 microgram/ml of bPTH and/or PTH-Inh. PTH fully activated cAMP-PK in GT, and PTH-Inh completely inhibited PTH-stimulated increases in cyclic AMP content and cAMP-PK activity. When endogenous protein substrates were sought for cAMP-PK, three phosphoproteins of 55,000, 43,000, and 38,000 mol wt maximally increased their phosphorylation by 30% after 12-min incubation with bPTH. Dephosphorylation of proteins of 200,000 and 120,000 mol wt was also observed. These data are consistent with the hypothesis that PTH action in bone is mediated by the phosphorylation and dephosphorylation of specific substrates.

Cells cultured from human giant cell tumors of bone respond to parathyroid hormone

1976 ◽  
Vol 22 (S1) ◽  
pp. 269-274 ◽  
Author(s):  
S. R. Goldring ◽  
J. -M. Dayer ◽  
R. G. G. Russell ◽  
H. J. Mankin ◽  
S. M. Krane
Keyword(s):  
Parathyroid Hormone ◽  
Giant Cell ◽  
Giant Cell Tumors ◽  
Tumors Of Bone ◽  
Cells Cultured

Characterization of Cells Cultured From Human Giant-Cell Tumors of Bone

1990 ◽  
Vol &NA; (258) ◽  
pp. 304???309
Author(s):  
SETSURO KOMIYA ◽  
YASUYUKI SASAGURI ◽  
AKIO INOUE ◽  
MASANORI NAKASHIMA ◽  
SABURO YAMAMOTO ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumors ◽  
Tumors Of Bone ◽  
Cells Cultured

Response to Hormones of Cells Cultured from Human Giant Cell Tumors of Bone*

1978 ◽  
Vol 46 (3) ◽  
pp. 425-433 ◽  
Author(s):  
STEVEN R. GOLDRING ◽  
JEAN-MICHEL DAYER ◽  
R. GRAHAM ◽  
G. RUSSELL ◽  
HENRY J. MANKIN ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumors ◽  
Tumors Of Bone ◽  
Cells Cultured

Bradykinin stimulates prostaglandin E2 formation in isolated human osteoblast-like cells

1990 ◽  
Vol 10 (1) ◽  
pp. 121-126 ◽  
Author(s):  
Östen Ljunggren ◽  
Jan Rosenquist ◽  
Maria Ransjö ◽  
Ulf H. Lerner
Keyword(s):  
Parathyroid Hormone ◽  
Cyclic Amp ◽  
Prostaglandin E2 ◽  
Trabecular Bone ◽  
Human Osteoblast ◽  
Human Osteoblasts ◽  
Human Trabecular Bone ◽  
Stimulation Of ◽  
In Cells

The effect of bradykinin on prostaglandin E2 formation in cells from human trabecular bone has been studied. The cells responded to parathyroid hormone with enhanced cyclic AMP formation and were growing as cuboidal-shaped, osteoblast-like cells. In these isolated human osteoblast-like cells, bradykinin (1 μmol/l) caused a rapid (5 min) stimulation of prostaglandin E2 formation. This finding indicates that human osteoblasts are equipped with receptors for bradykinin linked to an increase in prostaglandin formation.

Giant Cell Tumor of the Talar Neck

2007 ◽  
Vol 97 (3) ◽  
pp. 225-228 ◽  
Author(s):  
Hakan Selek ◽  
Hamza Özer ◽  
Sacit Turanli ◽  
Özlem Erdem
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Clinical Signs ◽  
Cell Tumor ◽  
Giant Cell Tumors ◽  
Radiographic Appearance ◽  
Aneurysmal Bone Cysts ◽  
Tumors Of Bone ◽  
Brown Tumors ◽  
Small Bones

We describe a patient with a giant cell tumor in the talar head and neck of the left foot who was diagnosed as having osteochondritis dissecans and treated with arthroscopic drilling in this same location 3 years earlier. Giant cell tumors can be confused with several conditions, including giant cell reparative granulomas, brown tumors, and aneurysmal bone cysts. Giant cell tumors of bone typically occur in the epiphysis of long bones, including the distal femur and proximal tibia. They are uncommonly found in the small bones of the foot or ankle, and talar involvement is rare. Despite this rarity, the radiographic appearance and clinical signs of talar lesions should be considered in the differential diagnosis of nontraumatic conditions in the foot. (J Am Podiatr Med Assoc 97(3): 225–228, 2007)

scholarly journals Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0148401 ◽  
Author(s):  
Kenta Mukaihara ◽  
Yoshiyuki Suehara ◽  
Shinji Kohsaka ◽  
Keisuke Akaike ◽  
Yu Tanabe ◽  
...  
Keyword(s):  
Protein Expression ◽  
Giant Cell ◽  
Expression Profiling ◽  
Giant Cell Tumors ◽  
Tumors Of Bone

Giant-Cell Tumors of Bone and Progesterone Receptors

Orthopedics ◽  
2003 ◽  
Vol 26 (12) ◽  
pp. 1209-1212
Author(s):  
Nikolaos Demertzis ◽  
Fani Kotsiandri ◽  
Ioulia Giotis ◽  
Nikiphoros Apostolikas
Keyword(s):  
Giant Cell ◽  
Progesterone Receptors ◽  
Giant Cell Tumors ◽  
Tumors Of Bone
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