Stereological studies on the epiphyseal growth plate in low phosphate, vitamin D-deficiency rickets with special reference to the distribution of matrix vesicles

1984 ◽  
Vol 36 (1) ◽  
pp. 95-101 ◽  
Author(s):  
Finn P. Reinholt ◽  
Anders Hjerpe ◽  
Kjell Jansson ◽  
Bengt Engfeldt
Keyword(s):  
Vitamin D ◽  
Special Reference ◽  
Vitamin D Deficiency ◽  
Growth Plate ◽  
Matrix Vesicles ◽  
Epiphyseal Growth Plate ◽  
Deficiency Rickets

Effects of Hypophysectomy on the Occurrence and Calcifiability of Matrix Vesicles in the Epiphyseal Growth Plate of Immature Rats

1980 ◽  
Vol 38 ◽  
pp. 578-579
Author(s):  
S. I. Coleman ◽  
W. J. Dougherty
Keyword(s):  
Growth Plate ◽  
Matrix Vesicles ◽  
Epiphyseal Growth Plate ◽  
Hard Tissue ◽  
Hormonal Factors ◽  
Post Surgery ◽  
Mineral Deposition ◽  
Thin Sectioning ◽  
Integral Role ◽  
Cellular Secretion

In the cellular secretion theory of mineral deposition, extracellular matrix vesicles are believed to play an integral role in hard tissue mineralization (1). Membrane limited matrix vesicles arise from the plasma membrane of epiphyseal chondrocytes and tooth odontoblasts by a budding process (2, 3). Nutritional and hormonal factors have been postulated to play essential roles in mineral deposition and apparently have a direct effect on matrix vesicles of calcifying cartilage as concluded by Anderson and Sajdera (4). Immature (75-85 gm) Long-Evans hooded rats were hypophysectomized by the parapharyngeal approach and maintained fourteen (14) days post-surgery. At this time, the animals were anesthetized and perfusion fixed in cacodylate buffered 2.5% glutaraldehyde. The proximal tibias were quickly dissected out and split sagittally. One half was used for light microscopy (LM) and the other for electron microscopy (EM). The halves used for EM were cut into blocks approximately 1×3 mm. The tissue blocks were prepared for ultra-thin sectioning and transmission EM. The tissue was oriented so as to section through the epiphyseal growth plate from the zone of proliferating cartilage on down through the hypertrophic zone and into the initial trabecular bone. Sections were studied stained (double heavy metal) and unstained.

Healing of vitamin D deficiency rickets complicating hypophosphatasia suggests a role beyond circulating mineral sufficiency for vitamin D in musculoskeletal health

Bone ◽  
2020 ◽  
Vol 136 ◽  
pp. 115322
Author(s):  
Elizabeth L. Lin ◽  
Gary S. Gottesman ◽  
William H. McAlister ◽  
Vinieth N. Bijanki ◽  
Karen E. Mack ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Musculoskeletal Health ◽  
Deficiency Rickets

The Many Faces of Vitamin D Deficiency Rickets

2000 ◽  
Vol 21 (9) ◽  
pp. 296-302
Author(s):  
Terence A. Joiner ◽  
Carol Foster ◽  
Thomas Shope
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Deficiency Rickets ◽  
The Many

The diagnosis of vitamin D deficiency rickets

1975 ◽  
Vol 3 (2) ◽  
pp. 105-110 ◽  
Author(s):  
W. H. Opie ◽  
C. J. B. Muller ◽  
H. Kamfer
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Deficiency Rickets
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