Proliferative activity of mixed hyperplastic adenomatous polyp/serrated adenoma in the large intestine, measured by PCNA (proliferating cell nuclear antigen)

1996 ◽  
Vol 31 (2) ◽  
pp. 207-213 ◽  
Author(s):  
Nobuhiko Fujishima
Keyword(s):  
Large Intestine ◽  
Adenomatous Polyp ◽  
Proliferating Cell Nuclear Antigen ◽  
Proliferative Activity ◽  
Nuclear Antigen ◽  
Serrated Adenoma ◽  
Proliferating Cell

scholarly journals Parathyroid Gland Carcinoma in a Wistar Rat

2003 ◽  
Vol 40 (2) ◽  
pp. 203-206 ◽  
Author(s):  
V. Pace ◽  
S. Scarsella ◽  
E. Perentes
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Proliferative Activity ◽  
Wistar Rat ◽  
Anaplastic Carcinoma ◽  
Nuclear Antigen ◽  
Ki 67 ◽  
Carcinogenicity Study ◽  
Thyroid Transcription Factor ◽  
Gland Carcinoma ◽  
Proliferating Cell

An anaplastic carcinoma was found in one of the two parathyroids of a 2-year-old male Wistar rat, which was sacrificed at the end of a carcinogenicity study. Morphologically, it was characterized by the presence of nodular areas of pleomorphic and dense cells with numerous atypical mitoses and large regions of smaller and dark monomorphic cells devoid of mitoses and forming small cystic spaces. Local invasion of the capsule and pronounced compression of the parenchyma of the thyroid gland were observed. Immunohistochemically, the tumor was markedly positive for the parathyroid hormone and negative for the thyroid transcription factor. The proliferative activity was assessed by immunostaining the endogenous cell proliferation associated-antigen Ki-67, and the proliferating cell nuclear antigen. The diagnosis of carcinoma of the parathyroid was made on the basis of microscopic and immunohistochemical findings.

scholarly journals The effect of laser on remanescent liver tissue after 90% hepatectomy in rats

2006 ◽  
Vol 21 (suppl 1) ◽  
pp. 29-32 ◽  
Author(s):  
Alexandre Ferreira Oliveira ◽  
Tiago Castro e Silva ◽  
Ajith Kumar Sankarankutty ◽  
Eduardo Garcia Pacheco ◽  
Juliana Ferreira ◽  
...  
Keyword(s):  
Partial Hepatectomy ◽  
Proliferating Cell Nuclear Antigen ◽  
Proliferative Activity ◽  
Wistar Rats ◽  
Liver Parenchyma ◽  
Serum Levels ◽  
Nuclear Antigen ◽  
Serum Aminotransferases ◽  
Hepatic Injuries ◽  
Proliferating Cell

PURPOSE: To evaluate the effect of laser beam on remanescent liver after partial hepatectomy 90%. METHODS: Wistar rats, (N= 42), were divided into six groups with seven specimens each. The partial hepatectomy (HP) was performed in all animals through exeresis of approximately 90% of the liver parenchyma. The animals from groups HP and Laser application, HPL24, HPL48 and HPL72 undertook laser irradiation carried out through application (dose of 22.5 J/cm²) in five different sites in the remanescent liver. The rats were then sacrificed 24, 48 and 72hours after HP procedure, for the liver regeneration analysis,using the Proliferating Cell Nuclear Antigen (PCNA),and for dosage of serum aminotransferases. RESULTS: Were demonstrated an increase of the serum levels of alanine aminotransferase for the group of 24 hours and a decrease for the group of 72 hours exposed to laser. The index of marked cells had a considerable more improvement for the group of 72 hours exposed in laser compared to other groups. CONCLUSION: Laser did not cause hepatic injuries additional to the partial hepatectomy and perhaps led to a benefit by stimulating the proliferative activity.

scholarly journals The role of HER2/neu, BCL2, p53 genes and proliferating cell nuclear protein as molecular prognostic parameters in localized prostate carcinoma

2004 ◽  
Vol 122 (3) ◽  
pp. 124-127 ◽  
Author(s):  
Gilvan Neiva Fonseca ◽  
Miguel Srougi ◽  
Katia Ramos Moreira Leite ◽  
Luciano João Nesrallah ◽  
Valdemar Ortiz
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Proliferating Cell Nuclear Antigen ◽  
Proliferative Activity ◽  
Tumor Volume ◽  
Tumor Stage ◽  
Nuclear Antigen ◽  
Prognostic Parameters ◽  
P53 Expression ◽  
Proliferating Cell

CONTEXT: Prostate cancer is the most frequent solid genitourinary neoplasm in men. Involvement of several genes has been described in the promotion and progression of prostate carcinoma. OBJECTIVE: To study the expression of the oncogenes HER2/neu and BCL2, tumor suppressor gene p53 and the tumor proliferation rate in 150 radical prostatectomy specimens, in order to define their role as prognostic parameters in localized prostate cancer. TYPE OF STUDY: Prospective study. SETTING: Universidade Federal de São Paulo and Hospital Sírio Libanês, Sao Paulo PARTICIPANTS: One hundred and fifty men who were submitted to radical prostatectomy between August 1997 and August 1998, for localized prostate cancer. MAIN MEASUREMENTS: All specimens underwent evaluation in their entirety, to determine tumor volume percentage, tumor extent and Gleason score. Immunohistochemistry was performed to determine gene expression using anti- HER2/neu, BCL2 and p53 antibodies, and proliferating cell nuclear antigen. The chi-squared test was used for correlation between gene expression, proliferative activity and histological variables. RESULTS: Thirty percent of the cases were p53 positive. There was positive correlation between p53 expression and tumor stage. The p53 expression was 22.9% and 42.6% for pT2 and pT3 tumors, respectively (p = 0.01). Expression of HER2/neu, BCL2 and proliferating cell nuclear antigen was identified in 66%, 23% and 43% of patients, respectively. There was no correlation between these three parameters and tumor volume, Gleason score or tumor stage. CONCLUSION: One-third of prostate adenocarcinomas express p53 protein, and this characteristic is related to tumor stage. HER2/neu is frequently expressed in prostate carcinomas, with no correlation with histological parameters. BCL2 is rarely expressed, and together with proliferative activity has no relationship with prognostic pathological variables in these neoplasms.

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