Chemical coding of neurons projecting to pelvic viscera in the male guinea pig: a study by retrograde transport and immunohistochemistry

1994 ◽  
Vol 26 (3) ◽  
pp. 262-270 ◽  
Author(s):  
D. Dami ◽  
B. S. Mitchell
Keyword(s):  
Guinea Pig ◽  
Retrograde Transport ◽  
Chemical Coding ◽  
Pelvic Viscera

Chemical coding and electrophysiology of enteric neurons expressing neurofilament 145 in guinea pig gastrointestinal tract

2001 ◽  
Vol 442 (3) ◽  
pp. 189-203 ◽  
Author(s):  
Hong-Zhen Hu ◽  
Na Gao ◽  
Zhong Lin ◽  
Chuanyun Gao ◽  
Sumei Liu ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Guinea Pig ◽  
Enteric Neurons ◽  
Chemical Coding

Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways

2002 ◽  
Vol 282 (4) ◽  
pp. L775-L781 ◽  
Author(s):  
Allen C. Myers ◽  
Radhika Kajekar ◽  
Bradley J. Undem
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Sensory Neurons ◽  
Large Diameter ◽  
Sensory System ◽  
Small Diameter ◽  
Allergic Inflammation ◽  
Primary Afferent ◽  
Chemical Coding ◽  
Low Threshold

In the vagal-sensory system, neuropeptides such as substance P and calcitonin gene-related peptide (CGRP) are synthesized nearly exclusively in small-diameter nociceptive type C-fiber neurons. By definition, these neurons are designed to respond to noxious or tissue-damaging stimuli. A common feature of visceral inflammation is the elevation in production of sensory neuropeptides. Little is known, however, about the physiological characteristics of vagal sensory neurons induced by inflammation to produce substance P. In the present study, we show that allergic inflammation of guinea pig airways leads to the induction of substance P and CGRP production in large-diameter vagal sensory neurons. Electrophysiological and anatomical evidence reveals that the peripheral terminals of these neurons are low-threshold Aδ mechanosensors that are insensitive to nociceptive stimuli such as capsaicin and bradykinin. Thus inflammation causes a qualitative change in chemical coding of vagal primary afferent neurons. The results support the hypothesis that during an inflammatory reaction, sensory neuropeptide release from primary afferent nerve endings in the periphery and central nervous system does not require noxious or nociceptive stimuli but may also occur simply as a result of stimulation of low-threshold mechanosensors. This may contribute to the heightened reflex physiology and pain that often accompany inflammatory diseases.

scholarly journals Distribution and chemical coding pattern of somatostatin immunoreactivity in the dorsal striatum of the guinea pig

2012 ◽  
Vol 49 (4) ◽  
pp. 690-699 ◽  
Author(s):  
Barbara Wasilewska ◽  
Anna Robak ◽  
Maciej Równiak ◽  
Krystyna Bogus-Nowakowska ◽  
Janusz Najdzion ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Dorsal Striatum ◽  
Chemical Coding ◽  
Somatostatin Immunoreactivity

Chemical coding of neurons that project from different regions of intestine to the coeliac ganglion of the guinea pig

1995 ◽  
Vol 56 (1-2) ◽  
pp. 15-25 ◽  
Author(s):  
Patricia T. Mann ◽  
John B. Furness ◽  
Sueli Pompolo ◽  
Michael Mäder
Keyword(s):  
Guinea Pig ◽  
Chemical Coding
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