Late onset hepatic failure due to hepatitis B virus with mutations in the pre-core region

1995 ◽  
Vol 30 (5) ◽  
pp. 672-676
Author(s):  
Koujirou Takase ◽  
Youhei Oohashi ◽  
Takayuki Kihira ◽  
Hiromi Aonuma ◽  
Minoru Hamada ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatic Failure ◽  
Late Onset ◽  
Core Region ◽  
B Virus ◽  
Late Onset Hepatic Failure

Expression of hepatitis B viral core region in mammalian cells

1986 ◽  
Vol 6 (5) ◽  
pp. 1393-1400
Author(s):  
M J Roossinck ◽  
S Jameel ◽  
S H Loukin ◽  
A Siddiqui
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Mammalian Cells ◽  
Expression System ◽  
Core Region ◽  
Core Antigen ◽  
Northern Blot Hybridization ◽  
The Core ◽  
B Virus ◽  
Nuclease Mapping

We studied the expression of the core region of the hepatitis B virus genome in mammalian cells with recombinant plasmid vectors. Stably transformed rat fibroblast cell lines were established by transfection with vectors containing subgenomic and genome-length hepatitis B virus DNA, followed by G418 selection. The RNA transcripts directed by the core region were characterized by Northern blot hybridization and S1 nuclease mapping. Using the chloramphenicol acetyltransferase gene expression system, the promoter activity located upstream of the core open reading frame was confirmed. The synthesis of core and e polypeptides was studied with a commercial radioimmunoassay. These studies show that partial deletion of the precore sequences abolished secretion of the e antigen, but there was pronounced synthesis of the core antigen in transfected cells.

scholarly journals Precore/core region mutations of hepatitis B virus related to clinical severity

2016 ◽  
Vol 22 (17) ◽  
pp. 4287 ◽  
Author(s):  
Hong Kim ◽  
Seoung-Ae Lee ◽  
Seung Yeon Do ◽  
Bum-Joon Kim
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Region ◽  
Clinical Severity ◽  
B Virus

561 EFFECT OF ANTIVIRAL TREATMENTS IN EVOLUTION OF HEPATITIS B VIRUS (HBV) CORE REGION EPITOPES

2009 ◽  
Vol 50 ◽  
pp. S207
Author(s):  
M. Homs ◽  
R. Jardi ◽  
M. Buti ◽  
D. Tabernero ◽  
P. Fernandez-Fernandez ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Region ◽  
B Virus

Rapid detection and clinical significance of mutations in the promoter and the pre-core region of hepatitis B virus genome

1998 ◽  
Vol 28 ◽  
pp. 108
Author(s):  
C. Grandjacques ◽  
P. Pradat ◽  
L. Stuyver ◽  
C. Pichoud ◽  
M. Maisonnas ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Significance ◽  
Rapid Detection ◽  
Virus Genome ◽  
Core Region ◽  
B Virus

Association between frequency of amino acid changes in core region of hepatitis B virus (HBV) and the presence of precore mutation in Japanese HBV carriers

1997 ◽  
Vol 32 (5) ◽  
pp. 611-622 ◽  
Author(s):  
Tatsunobu Karasawa ◽  
Takuji Shirasawa ◽  
Yasuhiko Okawa ◽  
Akira Kuramoto ◽  
Noritomo Shimada ◽  
...  
Keyword(s):  
Amino Acid ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Region ◽  
Precore Mutation ◽  
B Virus
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