Detection of anti-double and anti-single stranded DNA antibodies in chronic liver disease: Significance of anti-double stranded DNA antibody in autoimmune hepatitis

1994 ◽  
Vol 29 (2) ◽  
pp. 152-158 ◽  
Author(s):  
Kimiaki Tsuchiya ◽  
Kendo Kiyosawa ◽  
Haruhiko Imai ◽  
Takeshi Sodeyama ◽  
Seiichi Furuta
Keyword(s):  
Liver Disease ◽  
Autoimmune Hepatitis ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Single Stranded Dna ◽  
Double Stranded Dna ◽  
Dna Antibodies

scholarly journals Autoimmune Hepatitis Prevalence among Patients from Saudi Arabia with Chronic Liver Disease Referred for Transient Elastography

2021 ◽  
Vol 12 (06) ◽  
pp. 251-260
Author(s):  
Rajaa M. Alshanketi ◽  
Reem Jabbad ◽  
Bayan Baghlaf ◽  
Romaysaa Al-Yamani ◽  
Majed Alsahafi ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Liver Disease ◽  
Autoimmune Hepatitis ◽  
Chronic Liver Disease ◽  
Transient Elastography ◽  
Chronic Liver

Diagnostic value and utility of the simplified International Autoimmune Hepatitis Group (IAIHG) criteria in acute and chronic liver disease

Hepatology ◽  
2009 ◽  
Vol 50 (2) ◽  
pp. 538-545 ◽  
Author(s):  
Andrew D. Yeoman ◽  
Rachel H. Westbrook ◽  
Thawab Al-Chalabi ◽  
Ivana Carey ◽  
Nigel D. Heaton ◽  
...  
Keyword(s):  
Liver Disease ◽  
Autoimmune Hepatitis ◽  
Chronic Liver Disease ◽  
Diagnostic Value ◽  
Chronic Liver ◽  
International Autoimmune Hepatitis Group

scholarly journals Clinical spectrum of chronic liver disease with final outcome in children at a tertiary centre: A single - centre study

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Iqtadar Seerat ◽  
Eitzaz UD Din Khan ◽  
Muhammad Atique ◽  
Usman Iqbal Aujla
Keyword(s):  
Liver Disease ◽  
Autoimmune Hepatitis ◽  
Chronic Liver Disease ◽  
Final Outcome ◽  
Chronic Liver ◽  
Clinical Spectrum ◽  
Single Centre ◽  
Centre Study ◽  
Tertiary Centre ◽  
Single Centre Study

Background and Objectives: Chronic liver disease (CLD) in children present a broad spectrum of symptoms. Limited resources in Paediatric Hepatology in developing countries like Pakistan present considerable challenges in investigating and treating children with chronic liver disease in a timely fashion. This study aimed to determine the spectrum and outcomes of CLD other than chronic hep B & C virus (HBV& HCV) liver disease in children. Methods: This retrospective descriptive study was conducted at the Paediatric Gastroenterology and Hepatology Department, Pakistan Kidney and Liver Institute and Research Centre in Lahore, Pakistan. The duration of the study was from August 2019 to January 2020. A total of 162 children of CLD were seen during this period of time. Of 162 there were 130 children with chronic HBV & HCV who were excluded from this study. 32 children aged 15 years or younger with chronic liver disease were included. The referrals were received from primary and secondary health care centres in different parts of the country. The data were collected from hospital electronic medical records database and then incorporated into a spreadsheet for analysis. The statistical analysis was performed by applying t-test with p value determined. Results: Of 32 children autoimmune hepatitis (n=11; 34.3%) was the most common cause for chronic liver disease referrals, followed by progressive familial intrahepatic cholestasis type-2, (n=7; 21.8%), post Kasai for biliary atresia, (n=4; 12.5%), glycogen storage disease type-1 (n=5; 15.6%), Wilson disease (n=3; 9.3%) and primary sclerosing cholangitis (n=2; 6.2%). The diagnosis was principally established with the assistance of liver ultrasound, liver biopsy, magnetic resonance cholangiopancreatography and genetic testing. Conclusion: Autoimmune hepatitis was the most common chronic liver disease. Our systematic approach, in addition to an extensive workup, helped us to diagnose and then initiate an appropriate treatment, which resulted in a more optimal outcome. Prompt referrals to tertiary centres are recommended where resources and expertise are available to reduce patient morbidity and mortality. doi: https://doi.org/10.12669/pjms.37.3.3862 How to cite this:Seerat I, Khan ED, Atique M, Aujla UI. Clinical spectrum of chronic liver disease with final outcome in children at a tertiary centre: A single - centre study. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3862 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Genetic predictors of spontaneous viral elimination or chronic liver disease in hepatitis C infection

2001 ◽  
Vol 120 (5) ◽  
pp. A7-A7
Author(s):  
S ROSS ◽  
S MASCHERETTI ◽  
H HINRICHSEN ◽  
P BUGGISCH ◽  
U FOELSCH ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Hepatitis C Infection ◽  
Genetic Predictors
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