In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery

1995 ◽  
Vol 23 (4) ◽  
pp. 397-406 ◽  
Author(s):  
Claudia S. Leopold ◽  
David R. Friend
Keyword(s):  
Drug Delivery ◽  
Aspartic Acid ◽  
Pharmacokinetic Study ◽  
Drug Carrier ◽  
Specific Drug ◽  
Colon Specific Drug Delivery

scholarly journals Albumin coated liposomes: a novel platform for macrophage specific drug delivery

2011 ◽  
Vol 1 (1) ◽  
pp. 2 ◽  
Author(s):  
Clément Vuarchey ◽  
Sushil Kumar ◽  
Reto Schwendener
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Cell Types ◽  
Specific Drug ◽  
Splenic Macrophages ◽  
Peg Liposomes ◽  
Short Time ◽  
Liposome Surface

Here we report a new and efficient approach of macrophage specific drug delivery by coating liposomes with albumin. Activated albumin was reacted with liposomes containing polyethylene glycol (PEG) as hydrophilic spacers to create a flexible layer of covalently bound albumin molecules on the liposome surface. Albumin coated liposomes were taken up faster and more efficiently than uncoated liposomes by murine macrophages. Liposome uptake was significantly higher in macropha - ges as compared to other cell types tested (endothelial cells, fibroblasts, tumor cells), suggesting specificity for macrophages. In vivo, splenic macrophages phagocytosed BSA coated liposomes (BSA-L) at faster rates compared to conventional liposomes (L) and PEG liposomes (PEG-L). To prove the effectiveness of this new macrophage specific drug carrier, the bisphosphonates clodronate and zoledronate were encapsulated in BSA-L and compared with conventional liposomes. <em>In vitro</em>, treatment of macrophages with clodronate or zoledronate in BSA-L led to cytotoxic activity within a very short time and to up to 50-fold reduced IC50 concentrations. <em>In vivo</em>, clodronate encapsulated in BSA-L depleted splenic macrophages at a 5-fold lower concentration as conventional clodronate-liposomes. Our results highlight the pharmaceutical benefits of albumin-coated liposomes for macrophage specific drug delivery.

Colonic Bacterial Enzymes

2018 ◽  
pp. 71-99 ◽  
Author(s):  
Srushti M. Tambe ◽  
Namita D. Desai
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Specific Drug ◽  
Bacterial Enzymes ◽  
In Vitro Drug Release ◽  
Pharmaceutical Dosage Forms ◽  
Colon Specific Drug Delivery

This chapter reviews various enzymes produced by the colonic microflora and their utilization in the development of pharmaceutical dosage forms to achieve colon-specific drug delivery. This chapter discusses the applications of colonic bacterial enzymes in order to surrogate colonic conditions in vivo so as to evaluate in vitro drug release from microbially triggered/enzymatically triggered colon-specific drug delivery systems. This chapter also discusses different methods to produce colonic bacterial enzymes as well as use of probiotics as a source to produce colonic bacterial enzymes.

In vitro and in vivo evaluation of a novel capsule for colon-specific drug delivery

2009 ◽  
Vol 98 (8) ◽  
pp. 2626-2635 ◽  
Author(s):  
Min Han ◽  
Qiu-Li Fang ◽  
Hong-Wei Zhan ◽  
Tao Luo ◽  
Wen-Quan Liang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Specific Drug ◽  
In Vivo Evaluation ◽  
Colon Specific Drug Delivery

Smart nanocomposite hydrogels based on azo crosslinked graphene oxide for oral colon-specific drug delivery

2016 ◽  
Vol 27 (31) ◽  
pp. 315105 ◽  
Author(s):  
Lin Hou ◽  
Yuyang Shi ◽  
Guixiang Jiang ◽  
Wei Liu ◽  
Huili Han ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Specific Drug ◽  
Nanocomposite Hydrogels ◽  
Colon Specific Drug Delivery
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