Functional role of low-voltage-activated dihydropyridine-sensitive Ca channels during the action potential in adult rat sensory neurones

1996 ◽  
Vol 431 (S6) ◽  
pp. 954-963 ◽  
Author(s):  
Arnaldo Ferroni ◽  
A. Galli ◽  
M. Mazzanti
Keyword(s):  
Action Potential ◽  
Functional Role ◽  
Low Voltage ◽  
Ca Channels ◽  
Sensory Neurones ◽  
Adult Rat

Distribution, cellular localization and functional role of CCR2 chemokine receptors in adult rat brain

2002 ◽  
Vol 81 (2) ◽  
pp. 257-269 ◽  
Author(s):  
G. Banisadr ◽  
F. Quéraud-Lesaux ◽  
M. C. Boutterin ◽  
D. Pélaprat ◽  
B. Zalc ◽  
...  
Keyword(s):  
Rat Brain ◽  
Chemokine Receptors ◽  
Functional Role ◽  
Cellular Localization ◽  
Adult Rat ◽  
Adult Rat Brain

scholarly journals The functional role of electrophysiological heterogeneity in the rabbit ventricle during rapid pacing and arrhythmias

2013 ◽  
Vol 304 (9) ◽  
pp. H1240-H1252 ◽  
Author(s):  
Martin J. Bishop ◽  
Edward J. Vigmond ◽  
Gernot Plank
Keyword(s):  
Action Potential ◽  
Functional Role ◽  
Computational Models ◽  
Homogeneous Model ◽  
Conduction Block ◽  
Tissue Level ◽  
Functional Importance ◽  
Wavefront Propagation ◽  
Rapid Pacing

Electrophysiological heterogeneity in action potential recordings from healthy intact hearts remains highly variable and, where present, is almost entirely abolished at fast pacing rates. Consequently, the functional importance of intrinsic action potential duration (APD) heterogeneity in healthy ventricles, and particularly its role during rapidly activating reentrant arrhythmias, remain poorly understood. By incorporating both transmural and apicobasal APD heterogeneity within a biventricular rabbit computational model and comparing with an equivalent homogeneous model, we directly investigated the functional importance of intrinsic APD heterogeneity under fast pacing and arrhythmogenic protocols. Although differences in APD were significantly modulated at the tissue level during pacing and further reduced as pacing frequency increased, small differences were still noticeable. Such differences were further marginally accentuated/attenuated via electrotonic effects relative to wavefront propagation directions. The remaining small levels of APD heterogeneity under the fastest pacing frequencies resulted in arrhythmia initiation via heterogeneous conduction block, in contrast to complete block in the homogeneous model. Such induction mechanisms were more evident during premature stimuli at slower paced rhythms where intrinsic heterogeneity remained to a greater degree. During sustained arrhythmias, however, intrinsic heterogeneity made little difference to overall reentrant behavior, either visually, or in terms of duration, metrics quantifying filament/phase singularity dynamics, and global electrocardiogram characteristics. These findings suggest that, despite being important during arrhythmia initiation, intrinsic electrophysiological heterogeneity plays little functional role during rapid pacing and sustained arrhythmia dynamics in the healthy ventricle and thus questions the need to incorporate such detail in computational models when simulating rapid arrhythmias.

Expression and functional role of c-Kit and erbB2 in human hepatoblastoma.

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
B Steiger ◽  
I Leuschner ◽  
D Denkhaus ◽  
D von Schweinitz ◽  
T Pietsch
Keyword(s):  
Functional Role
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