Immunohistochemical distribution of calcitonin gene-related peptide in nerve fibres of the anterior buccal gland of the rat

1996 ◽  
Vol 28 (1) ◽  
pp. 1-5 ◽  
Author(s):  
J. Törnwall ◽  
Y. T. Konttinen ◽  
H. Uusitalo
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Nerve Fibres ◽  
Related Peptide ◽  
Calcitonin Gene

Diverse interactions of calcitonin gene related peptide and nitric oxide in the gastric and cutaneous microcirculation

1995 ◽  
Vol 73 (7) ◽  
pp. 991-994 ◽  
Author(s):  
P. Holzer ◽  
Ch. Wachter ◽  
M. Jocič ◽  
I. Th. Lippe ◽  
A. Heinemann ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gastric Mucosa ◽  
Calcitonin Gene Related Peptide ◽  
Afferent Nerve ◽  
Nerve Fibres ◽  
Related Peptide ◽  
Neurogenic Vasodilatation ◽  
Cutaneous Microcirculation ◽  
Cgrp Release ◽  
Calcitonin Gene

Calcitonin gene related peptide (CGRP) is the major mediator of afferent nerve mediated vasodilatation in the gastric mucosa and skin of the rat. Since receptors for CGRP occur on both the vascular endothelium and smooth muscle, it is conceivable that the vascular actions of CGRP involve multiple mechanisms. The vasodilator effect of rat CGRP-α in the rat gastric mucosa is indeed inhibited by blockade of nitric oxide (NO) synthesis, as is the gastric mucosal hyperemia in response to gastric acid challenge, which is mediated by CGRP release from afferent nerve fibres. In contrast, the vasodilator response to rat CGRP-α in the rat hind paw and the CGRP-mediated vasodilatation evoked by antidromic stimulation of afferent nerve fibres do not depend on the formation of NO. These data indicate that NO plays regionally different roles in the local vasodilator action of CGRP. NO is a secondary vasorelaxant messenger of CGRP in the gastric, but not in the cutaneous, microcirculation. However, this L-arginine-derived autacoid may have a role in the irritant-induced CGRP release from afferent vasodilator fibres in the skin.Key words: calcitonin gene related peptide, nitric oxide, microcirculation, gastric mucosa, skin, afferent nerve fibres, neurogenic vasodilatation.

The distribution and origin of calcitonin gene-related peptide-containing nerve fibres in feline dental pulp

1987 ◽  
Vol 86 (6) ◽  
pp. 585-589 ◽  
Author(s):  
S. Wakisaka ◽  
H. Ichikawa ◽  
S. Nishikawa ◽  
S. Matsuo ◽  
Y. Takano ◽  
...  
Keyword(s):  
Dental Pulp ◽  
Calcitonin Gene Related Peptide ◽  
Nerve Fibres ◽  
Related Peptide ◽  
Calcitonin Gene
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