Fine structures of the basophil infiltration in regional lymph nodes of the guinea-pig after the intradermal injection of T cell mitogens

1982 ◽  
Vol 38 (5) ◽  
pp. 621-622 ◽  
Author(s):  
M. Kimura ◽  
K. Takaya
Keyword(s):  
T Cell ◽  
Guinea Pig ◽  
Lymph Nodes ◽  
Intradermal Injection ◽  
Regional Lymph Nodes ◽  
Fine Structures

Cutaneous Lymphosarcoma of Helper/Inducer T-Cell Origin in a Calf

1987 ◽  
Vol 24 (6) ◽  
pp. 504-508 ◽  
Author(s):  
R. D. Zwahlen ◽  
A. Tontis ◽  
A. Schneider
Keyword(s):  
T Cell ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Mycosis Fungoides ◽  
Lymphoproliferative Disease ◽  
T Helper ◽  
Regional Lymph Nodes ◽  
Skin Nodules ◽  
Neoplastic Lymphocytes ◽  
Suggested Classification

A calf with a lymphoproliferative disease resembling human mycosis fungoides, had multiple, ulcerated skin nodules with enlarged regional lymph nodes. Tumor cells were 10–15 μm in diameter and had round to oval nuclei without indentations. Mitoses were regularly present. Pautrier's microabscesses were in the epidermis, and T-cell areas of regional lymph nodes were infiltrated by neoplastic cells. Demonstration of the T-helper/inducer origin of neoplastic lymphocytes suggested classification in analogy with human mycosis fungoides.

scholarly journals Pathology and Pathophysiology of Inhalational Anthrax in a Guinea Pig Model

2013 ◽  
Vol 81 (4) ◽  
pp. 1152-1163 ◽  
Author(s):  
Vladimir Savransky ◽  
Daniel C. Sanford ◽  
Emily Syar ◽  
Jamie L. Austin ◽  
Kevin P. Tordoff ◽  
...  
Keyword(s):  
Animal Model ◽  
Guinea Pig ◽  
Lymph Nodes ◽  
Guinea Pigs ◽  
Alternative Model ◽  
Lethal Dose ◽  
Clinical Signs ◽  
Regional Lymph Nodes ◽  
Content Type ◽  
Ames Strain

ABSTRACTNonhuman primates (NHPs) and rabbits are the animal models most commonly used to evaluate the efficacy of medical countermeasures against anthrax in support of licensure under the FDA's “Animal Rule.” However, a need for an alternative animal model may arise in certain cases. The development of such an alternative model requires a thorough understanding of the course and manifestation of experimental anthrax disease induced under controlled conditions in the proposed animal species. The guinea pig, which has been used extensively for anthrax pathogenesis studies and anthrax vaccine potency testing, is a good candidate for such an alternative model. This study was aimed at determining the median lethal dose (LD50) of theBacillus anthracisAmes strain in guinea pigs and investigating the natural history, pathophysiology, and pathology of inhalational anthrax in this animal model following nose-only aerosol exposure. The inhaled LD50of aerosolized Ames strain spores in guinea pigs was determined to be 5.0 × 104spores. Aerosol challenge of guinea pigs resulted in inhalational anthrax with death occurring between 46 and 71 h postchallenge. The first clinical signs appeared as early as 36 h postchallenge. Cardiovascular function declined starting at 20 h postexposure. Hematogenous dissemination of bacteria was observed microscopically in multiple organs and tissues as early as 24 h postchallenge. Other histopathologic findings typical of disseminated anthrax included suppurative (heterophilic) inflammation, edema, fibrin, necrosis, and/or hemorrhage in the spleen, lungs, and regional lymph nodes and lymphocyte depletion and/or lymphocytolysis in the spleen and lymph nodes. This study demonstrated that the course of inhalational anthrax disease and the resulting pathology in guinea pigs are similar to those seen in rabbits and NHPs, as well as in humans.

Facial Nerve Transection Causes Expansion of Myelin Autoreactive T Cells in Regional Lymph Nodes and T Cell Homing to the Facial Nucleus

Autoimmunity ◽  
1992 ◽  
Vol 13 (2) ◽  
pp. 117-126 ◽  
Author(s):  
Tomas Olsson ◽  
Per Diener ◽  
Åke Ljungdahl ◽  
Bo Höjeberg ◽  
Peter H. Van Der Meide ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Facial Nerve ◽  
Lymph Nodes ◽  
Nerve Transection ◽  
Facial Nucleus ◽  
Regional Lymph Nodes ◽  
Autoreactive T Cells ◽  
Cell Homing ◽  
T Cell Homing

Gastric T-cell lymphoma presenting with epithelioid granulomas mimicking tuberculosis in regional lymph nodes

2001 ◽  
Vol 36 (3) ◽  
pp. 190-194 ◽  
Author(s):  
Masaru Okuno ◽  
Rika Takenaka ◽  
Fusao Kawakami ◽  
Hideki Asakawa ◽  
Motomu Tsuji ◽  
...  
Keyword(s):  
T Cell ◽  
Lymph Nodes ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Regional Lymph Nodes

Primary Gastric T-Cell Lymphoma: Clinicopathologic Features and Treatment Outcome.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3355-3355
Author(s):  
Yeon Hee Park ◽  
Won Seog Kim ◽  
Soo-Mee Bang ◽  
Soon Il Lee ◽  
Ji Eun Uhm ◽  
...  
Keyword(s):  
T Cell ◽  
Lymph Nodes ◽  
Cell Lymphoma ◽  
International Prognostic Index ◽  
Gastric Lymphoma ◽  
T Cell Lymphoma ◽  
High Dose ◽  
Regional Lymph Nodes ◽  
Hematopoietic Stem ◽  
Primary Gastric Lymphoma

Abstract Primary gastric lymphoma is the most frequent type of extranodal malignant lymphoma. The large majority of cases are of B-cell lineage, while primary gastric T-cell lymphomas are exceedingly rare and least well characterized malignancy and the clinical features have been described only in a few case reports. In this study, we conducted a retrospective analysis to investigate the natural history and the clinical outcome after treatment. Between 1990 and 2004, 444 patients with primary gastric lymphoma had been diagnosed at four institutes. Among these 444 patients, 17 patients (3.8%) were identified as primary gastric lymphoma with T-cell immunophenotype. The pathologic review was performed by two experienced hematopathologist to confirm T-cell lymphoma with typical immunohistochemical features including CD3. All of the patients were staged according to the Mushoff system. Among these 17 gastirc T-cell lymphoma patients, 14 patients were treated with combination chemotherapy including CHOP with or without radiotherapy. The two patients were treated with high-dose chemotherapy with autologous peripheral hematopoietic stem cell transplantation. The median age of the 13 male and 4 female patients was 49 years (range 22–76 years). The pathologic subtypes of these patients with T-cell immunophenotype were as follows; precursor T-lymphoblastic lymphoma in 2 patients, peripheral T-cell lymphoma, unspecified in 6 patients, NK/T cell lymphoma in 3 patients, and T-cell others in 5 patients. The many of the patients showed poor performance status (PS), and high LDH level (65%). 12 patients (71%) showed stage III or IV diseases, and 9 patients (53%) showed high or high-risk according to the International Prognostic Index (IPI). A response to treatment was observed in 8 patients (47%), with 6 Complete Response (CR) and 2 Partial Response (PR). The median Progression-Free Survival (PFS) and Overall Survival (OS) were only 5 months (95% C.I.; 4–6 months), and 14 months (95% C.I.; 0–189 months). 5 patients of these 17 patients (29%) presented only in stomach and regional lymph nodes. The patients with localized gastric T-cell lymphoma showed good therapeutic outcome (median PFS; 53 months, median OS; 123 months, p =0.024 by log-rank test). Other clinical factors including PS, age, and LDH did not show clinical significance in this series. Although our series had limitation to interpret due to small population, this study showed that the incidence of this subtype of T-cell gastric lymphoma was very rare, and poor prognosis, like as other T-cell lymphoma. However, about 30% of the patients had localized diseases limited to gastric area and regional lymph nodes with relative good prognosis. New therapeutic strategies need to improve the outcome of patients with gastric T-cell lymphoma.

scholarly journals The IgE production is initially induced in subcutaneous fat and depends on extrafollicular B cells

2021 ◽  
Author(s):  
Dmitrii Borisovich Chudakov ◽  
Gulnar Vaisovna Fattakhova ◽  
Mariya Vladimirovna Konovalova ◽  
Daria Sergeevna Tsaregorotseva ◽  
Marina Alexandrovna Shevchenko ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Lymph Nodes ◽  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Fat Tissue ◽  
Class Switching ◽  
Regional Lymph Nodes

AbstractBackgroundGrowing body of evidence indicates that IgE production can be developed by mechanisms that differ from those responsible for IgG and IgA production. One potential possibility is generation of IgE producing cells from tissue-associated B-cells and/or through extrafollicular pathway. But the role of subcutaneous fat-associated B-cells in this process is poorly investigated. The aim of the present study was to investigate the role of different B- and T- cell subpopulations after long-term antigen administration in IgE response.MethodsBALB/c mice were immunized 3 times a eeks for 4 weeks in withers region enriched with subcutaneous fat with high and low antigen doses as well as by intraperitoneal route in region enriched with visceral fat for comparison.ResultsAfter long-term antigen administration that promotes the type of immune response which is more similar to one observed in young allergic children, subcutaneous fat tissue B-cells generates more rapid and active IgE class switched and IgE-produced cells. Although IgE production at later time points was initiated also in regional lymph nodes, the early IgE production was exclusively linked with subcutaneous fat. We observed that low-dose induced strong IgE production accompanied by minimal IgG1 production was linked with extrafollicular B-2 derived plasmablasts as well as extrafollicular T- helpers accumulation. Delayed IgE class switching in regional lymph nodes and visceral fat tissue was characterized by the absence of both stable plasmablasts and T-extrafollicular helpers accumulation.ConclusionExtrafollicular B- and T-cell responses in subcutaneous fat are necessary for early IgE class switching and sensitization process in the case of allergen penetration through skin.

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