Comparative study of the electrical and mechanical behaviour of an intact, semi-intact and isolated gastropode (Helix pomatia) smooth muscle preparation

1975 ◽  
Vol 31 (10) ◽  
pp. 1167-1170 ◽  
Author(s):  
R. W. Wabnitz
Keyword(s):  
Smooth Muscle ◽  
Comparative Study ◽  
Mechanical Behaviour ◽  
Helix Pomatia ◽  
Muscle Preparation ◽  
Smooth Muscle Preparation

Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation

2002 ◽  
Vol 59 (5) ◽  
pp. 513-519 ◽  
Author(s):  
Junko Hayashi ◽  
Toshikazu Sekine ◽  
Shigeyoshi Deguchi ◽  
Qing Lin ◽  
Syunji Horie ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Phenolic Compounds ◽  
Muscle Preparation ◽  
Smooth Muscle Preparation ◽  
Related Compounds

A method of measurement of longitudinal resistances in an isolated cardiac and smooth muscle preparation

1986 ◽  
Vol 406 (2) ◽  
pp. 232-233 ◽  
Author(s):  
W. Tuganowski ◽  
M. Bukowski ◽  
I. Korczyńska ◽  
B. Wójcik ◽  
K. Wasik
Keyword(s):  
Smooth Muscle ◽  
Muscle Preparation ◽  
Smooth Muscle Preparation ◽  
Method Of Measurement

scholarly journals THE SITE OF ACTION OF THE STAPHYLOCOCCUS ALPHA TOXIN

1961 ◽  
Vol 113 (1) ◽  
pp. 67-82 ◽  
Author(s):  
Alan P. Thal ◽  
Willadene Egner
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Flaccid Paralysis ◽  
Alpha Toxin ◽  
Muscle Preparation ◽  
High Concentration ◽  
Selective Effect ◽  
Smooth Muscle Preparation ◽  
Site Of Action

The present study concerns the site of action of the staphylococcus alpha toxin. This powerful necrotizing agent produced by pathogenic strains of staphylococcus is very probably important in the pathogenesis of localized staphylococcus disease and in the shock-like picture sometimes associated with staphylococcus septicemia. Our previous studies had suggested that the toxin has a selective effect on vascular smooth muscle. In investigating this problem further, the following observations were made. 1. The toxin produces an immediate hyperperistalsis and sustained increase in intraluminal tension progressing ultimately to atony and flaccid paralysis in the isolated smooth muscle preparation. 2. The addition of specific antitoxin prior to exposure to toxin prevents this reaction. However, when antitoxin is added after the toxin, no ameliorating effect is seen. 3. The toxin is rapidly and irreversibly bound to its substrate since washing the bowel segment 30 seconds after exposure to toxin fails to change the course of the reaction. 4. Vena caval segments exposed to toxin exhibit a similar initial rise in intraluminal tension followed by flaccid paralysis at which point they no longer respond to epinephrine stimulation. 5. When the toxin is infiltrated in the neighborhood of muscular blood vessels in the living rabbit selective necrosis of smooth muscle cells of the vessel walls is seen. 6. The selective effect on smooth muscle is emphasized by the failure of the toxin to affect the contractility of skeletal and cardiac muscle. 7. Perfusion of the isolated kidney and heart produces an increased resistance to flow after toxin is added to the perfusate. 8. Epithelial cells and fibroblasts in tissue culture exposed to high concentration of toxin for 2 hours are unaffected in their ability to recover and metabolise. This is in marked contrast to the effect on the smooth muscle preparation. The probability that the toxic effect on smooth muscle cells explains some of the local and systemic effects of staphylococcus infection is discussed.

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